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Compounds
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PRL-3 Inhibitor I
PRL-3 Inhibitor I
Synonyms
Sources
Names Used
CTRPv2
PRL-3 inhibitor I
PharmacoGx
PRL-3 Inhibitor I
External IDs
Database
Identifier
Smiles:
Brc1ccc(OCc2ccccc2Br)c(/C=C3/SC(=S)NC3=O)c1
Pubchem:
11983303
Annotated Targets
PTP4A3
FDA Approval Status
Not Approved
Plots
Cell Line Summary
Tissue Summary
Molecular Features
Number of cell lines tested with PRL-3
Inhibitor I (per dataset)
0
100
200
300
400
500
600
700
800
# cell lines
CCLE
GDSC1000
gCSI
GRAY
FIMM
UHNBreast
CTRPv2
0
0
0
0
0
0
811
Download SVG
Number of tissues tested with PRL-3
Inhibitor I (per dataset)
0
2
4
6
8
10
12
14
16
18
20
22
24
# tissues
CCLE
GDSC1000
gCSI
GRAY
FIMM
UHNBreast
CTRPv2
0
0
0
0
0
0
25
Download SVG
Dataset Select
all
CTRPv2
PRL-3 Inhibitor I: AAC
AAC
0.00
0.02
0.04
0.06
0.08
0.10
0.12
0.14
0.16
0.18
0.20
0.22
0.24
0.26
NCI-H1651
NCI-H1651
DV-90
DV-90
KG-1-C
KG-1-C
JHUEM-1
JHUEM-1
A204
A204
SF268
SF268
HGC-27
HGC-27
42-MG-BA
42-MG-BA
HCC1419
HCC1419
SF539
SF539
AML-193
AML-193
KP-4
KP-4
DMS 454
DMS 454
NCI-H1155
NCI-H1155
MDA-MB-157
MDA-MB-157
NCI-H1793
NCI-H1793
UO31
UO31
SH-4
SH-4
Hs 934.T
Hs 934.T
HOP-62
HOP-62
SCC-4
SCC-4
HS578BST
HS578BST
DEL
DEL
SK-ES-1
SK-ES-1
NCI-H2106
NCI-H2106
EKVX
EKVX
NCI-H2141
NCI-H2141
GCT
GCT
TYK-nu
TYK-nu
IGR-1
IGR-1
MOLM-6
MOLM-6
TUHR10TKB
TUHR10TKB
MOLT-13
MOLT-13
REH
REH
Caov-3
Caov-3
HuP-T4
HuP-T4
IPC-298
IPC-298
LoVo
LoVo
MDA-MB-435
MDA-MB-435
MM1-S
MM1-S
TE-1
TE-1
WM-793
WM-793
Hep G2
Hep G2
Panc 05.04
Panc 05.04
JL-1
JL-1
NCI-H322
NCI-H322
GMS-10
GMS-10
PA-TU-8988T
PA-TU-8988T
SCaBER
SCaBER
Hs 895.T
Hs 895.T
TE 617.T
TE 617.T
HL-60
HL-60
OCI-M1
OCI-M1
SIG-M5
SIG-M5
SK-N-FI
SK-N-FI
Set-2
Set-2
JM1
JM1
TC-71
TC-71
BT-474
BT-474
BT271
BT271
NCI-H1651
DV-90
KG-1-C
JHUEM-1
A204
SF268
HGC-27
42-MG-BA
HCC1419
SF539
AML-193
KP-4
DMS 454
NCI-H1155
MDA-MB-157
NCI-H1793
UO31
SH-4
Hs 934.T
HOP-62
SCC-4
HS578BST
DEL
SK-ES-1
NCI-H2106
EKVX
NCI-H2141
GCT
TYK-nu
IGR-1
MOLM-6
TUHR10TKB
MOLT-13
REH
Caov-3
HuP-T4
IPC-298
LoVo
MDA-MB-435
MM1-S
TE-1
WM-793
Hep G2
Panc 05.04
JL-1
NCI-H322
GMS-10
PA-TU-8988T
SCaBER
Hs 895.T
TE 617.T
HL-60
OCI-M1
SIG-M5
SK-N-FI
Set-2
JM1
TC-71
BT-474
BT271
NCI-H1651: 0.27
Synonyms: NCI-H1651, NCIH1651
DV-90: 0.25
Synonyms: DV-90, DV90
KG-1-C: 0.25
Synonyms: KG-1-C, KG1C
JHUEM-1: 0.24
Synonyms: JHUEM-1, JHUEM1
A204: 0.23
Synonyms: A204, A-204
SF268: 0.23
Synonyms: SF268
HGC-27: 0.23
Synonyms: HGC-27, HGC27
42-MG-BA: 0.23
Synonyms: 42-MG-BA, 42MGBA
HCC1419: 0.21
Synonyms: HCC1419, hcc1419
SF539: 0.21
Synonyms: SF539
AML-193: 0.21
Synonyms: AML-193, AML193
KP-4: 0.20
Synonyms: KP-4, KP4
DMS 454: 0.20
Synonyms: DMS 454, DMS_454, DMS454
NCI-H1155: 0.19
Synonyms: NCI-H1155, NCIH1155
MDA-MB-157: 0.19
Synonyms: MDA-MB-157, MDAMB157, mdamb157
NCI-H1793: 0.18
Synonyms: NCI-H1793, NCIH1793
UO31: 0.18
Synonyms: UO31, UO-31, U031
SH-4: 0.18
Synonyms: SH-4, SH4
Hs 934.T: 0.17
Synonyms: Hs 934.T, Hs_934.T, HS934T
HOP-62: 0.17
Synonyms: HOP-62, HOP62
SCC-4: 0.17
Synonyms: SCC-4, SCC4
HS578BST: 0.16
Synonyms: HS578BST
DEL: 0.15
Synonyms: DEL
SK-ES-1: 0.15
Synonyms: SK-ES-1, SKES1
NCI-H2106: 0.14
Synonyms: NCI-H2106, NCIH2106
EKVX: 0.14
Synonyms: EKVX
NCI-H2141: 0.14
Synonyms: NCI-H2141, NCIH2141
GCT: 0.14
Synonyms: GCT
TYK-nu: 0.14
Synonyms: TYK-nu, TYKNU
IGR-1: 0.13
Synonyms: IGR-1, IGR1
: 0.00
Synonyms:
: 0.00
Synonyms:
: 0.00
Synonyms:
: 0.00
Synonyms:
: 0.00
Synonyms:
MOLM-6: 0.00
Synonyms: MOLM-6, MOLM6
TUHR10TKB: 0.00
Synonyms: TUHR10TKB
MOLT-13: 0.00
Synonyms: MOLT-13, MOLT13
REH: 0.00
Synonyms: REH, Reh
Caov-3: 0.00
Synonyms: Caov-3, CAOV3
HuP-T4: 0.00
Synonyms: HuP-T4, HUP-T4, HUPT4
IPC-298: 0.00
Synonyms: IPC-298, IPC298
LoVo: 0.00
Synonyms: LoVo, LOVO
MDA-MB-435: 0.00
Synonyms: MDA-MB-435, MDA-MB-435S, MDAMB435S
MM1-S: 0.00
Synonyms: MM1-S, MM1S, MM.1S
TE-1: 0.00
Synonyms: TE-1, TE1
WM-793: 0.00
Synonyms: WM-793, WM793B, WM793
Hep G2: 0.00
Synonyms: Hep G2, Hep_G2, HEPG2
Panc 05.04: 0.00
Synonyms: Panc 05.04, Panc_05.04, PANC0504
JL-1: 0.00
Synonyms: JL-1, JL1
NCI-H322: 0.00
Synonyms: NCI-H322, NCIH322
GMS-10: 0.00
Synonyms: GMS-10, GMS10
PA-TU-8988T: 0.00
Synonyms: PA-TU-8988T, PATU8988T
SCaBER: 0.00
Synonyms: SCaBER, SCABER
Hs 895.T: 0.00
Synonyms: Hs 895.T, Hs_895.T, HS895T
TE 617.T: 0.00
Synonyms: TE 617.T, TE_617.T, TE617T
HL-60: 0.00
Synonyms: HL-60, HL60
OCI-M1: 0.00
Synonyms: OCI-M1, OCIM1
SIG-M5: 0.00
Synonyms: SIG-M5, SIGM5
SK-N-FI: 0.00
Synonyms: SK-N-FI, SKNFI
Set-2: 0.00
Synonyms: Set-2, Set2, SET-2, SET2
JM1: 0.00
Synonyms: JM1
TC-71: 0.00
Synonyms: TC-71, TC71
BT-474: 0.00
Synonyms: BT-474, BT474, bt474
BT271: 0.00
Synonyms: BT271
Download SVG
0.00
5.00
10.00
15.00
20.00
25.00
NCI-H508
NCI-H508
OCUM-1
OCUM-1
TTTHYROID
TTTHYROID
ZR-75-30
ZR-75-30
COLO-678
COLO-678
HCC-2108
HCC-2108
JHUEM-1
JHUEM-1
WM-983B
WM-983B
LMSU
LMSU
SNU-216
SNU-216
HOS
HOS
RH-18
RH-18
VMRC-RCW
VMRC-RCW
AsPC-1
AsPC-1
HuP-T3
HuP-T3
NCI-H1341
NCI-H1341
SKM-1
SKM-1
NCI-H1650
NCI-H1650
VM-CUB-1
VM-CUB-1
HCC4006
HCC4006
RD
RD
LU-65
LU-65
SK-UT-1
SK-UT-1
JHH-2
JHH-2
RL
RL
SK-MEL-30
SK-MEL-30
Caki-2
Caki-2
NCI-H520
NCI-H520
MONO-MAC-1
MONO-MAC-1
COR-L105
COR-L105
WM-115
WM-115
HT-1080
HT-1080
WM-266-4
WM-266-4
HCC2935
HCC2935
LU-99A
LU-99A
HEC-265
HEC-265
MKN1
MKN1
JK-1
JK-1
BT330
BT330
TCCSUP
TCCSUP
Daoy
Daoy
SW1573
SW1573
TYK-nu
TYK-nu
U251MG
U251MG
DEL
DEL
DMS 454
DMS 454
SK-ES-1
SK-ES-1
NCI-H1581
NCI-H1581
OVCAR-5
OVCAR-5
GCT
GCT
NCI-H2106
NCI-H2106
HOP-62
HOP-62
MDA-MB-453
MDA-MB-453
NCI-H1155
NCI-H1155
Saos-2
Saos-2
KP-4
KP-4
SF268
SF268
HGC-27
HGC-27
SF539
SF539
A204
A204
NCI-H508
OCUM-1
TTTHYROID
ZR-75-30
COLO-678
HCC-2108
JHUEM-1
WM-983B
LMSU
SNU-216
HOS
RH-18
VMRC-RCW
AsPC-1
HuP-T3
NCI-H1341
SKM-1
NCI-H1650
VM-CUB-1
HCC4006
RD
LU-65
SK-UT-1
JHH-2
RL
SK-MEL-30
Caki-2
NCI-H520
MONO-MAC-1
COR-L105
WM-115
HT-1080
WM-266-4
HCC2935
LU-99A
HEC-265
MKN1
JK-1
BT330
TCCSUP
Daoy
SW1573
TYK-nu
U251MG
DEL
DMS 454
SK-ES-1
NCI-H1581
OVCAR-5
GCT
NCI-H2106
HOP-62
MDA-MB-453
NCI-H1155
Saos-2
KP-4
SF268
HGC-27
SF539
A204
NCI-H508: 28.61 (log10 µM)
Synonyms: NCI-H508, NCIH508
OCUM-1: 22.24 (log10 µM)
Synonyms: OCUM-1, OCUM1
TTTHYROID: 11.33 (log10 µM)
Synonyms: TTTHYROID
ZR-75-30: 10.28 (log10 µM)
Synonyms: ZR-75-30, ZR7530, zr7530
COLO-678: 9.88 (log10 µM)
Synonyms: COLO-678, COLO 678, COLO678
HCC-2108: 8.90 (log10 µM)
Synonyms: HCC-2108, HCC2108
JHUEM-1: 8.32 (log10 µM)
Synonyms: JHUEM-1, JHUEM1
WM-983B: 7.86 (log10 µM)
Synonyms: WM-983B, WM983B
LMSU: 7.64 (log10 µM)
Synonyms: LMSU
SNU-216: 7.60 (log10 µM)
Synonyms: SNU-216, SNU216
HOS: 7.17 (log10 µM)
Synonyms: HOS
RH-18: 6.67 (log10 µM)
Synonyms: RH-18, RH18
VMRC-RCW: 6.50 (log10 µM)
Synonyms: VMRC-RCW, VMRCRCW
AsPC-1: 6.38 (log10 µM)
Synonyms: AsPC-1, ASPC1
HuP-T3: 6.34 (log10 µM)
Synonyms: HuP-T3, HUP-T3, HUPT3
NCI-H1341: 6.12 (log10 µM)
Synonyms: NCI-H1341, NCIH1341
SKM-1: 5.94 (log10 µM)
Synonyms: SKM-1, SKM1
NCI-H1650: 5.79 (log10 µM)
Synonyms: NCI-H1650, NCIH1650
VM-CUB-1: 5.75 (log10 µM)
Synonyms: VM-CUB-1, VM-CUB1, VMCUB1
HCC4006: 5.56 (log10 µM)
Synonyms: HCC4006
RD: 5.51 (log10 µM)
Synonyms: RD
LU-65: 5.41 (log10 µM)
Synonyms: LU-65, LU65
SK-UT-1: 5.32 (log10 µM)
Synonyms: SK-UT-1, SKUT1
JHH-2: 5.19 (log10 µM)
Synonyms: JHH-2, JHH2
RL: 4.83 (log10 µM)
Synonyms: RL
SK-MEL-30: 4.82 (log10 µM)
Synonyms: SK-MEL-30, SKMEL30
Caki-2: 4.55 (log10 µM)
Synonyms: Caki-2, CAKI2
NCI-H520: 4.52 (log10 µM)
Synonyms: NCI-H520, NCIH520
MONO-MAC-1: 4.46 (log10 µM)
Synonyms: MONO-MAC-1, MONOMAC1
COR-L105: 4.37 (log10 µM)
Synonyms: COR-L105, CORL105
: 0.00 (log10 µM)
Synonyms:
: 0.00 (log10 µM)
Synonyms:
: 0.00 (log10 µM)
Synonyms:
: 0.00 (log10 µM)
Synonyms:
: 0.00 (log10 µM)
Synonyms:
WM-115: 1.86 (log10 µM)
Synonyms: WM-115, WM115
HT-1080: 1.84 (log10 µM)
Synonyms: HT-1080, HT1080
WM-266-4: 1.80 (log10 µM)
Synonyms: WM-266-4, WM2664
HCC2935: 1.77 (log10 µM)
Synonyms: HCC2935
LU-99A: 1.75 (log10 µM)
Synonyms: LU-99A, LU99
HEC-265: 1.71 (log10 µM)
Synonyms: HEC-265, HEC265
MKN1: 1.70 (log10 µM)
Synonyms: MKN1, MKN-1
JK-1: 1.67 (log10 µM)
Synonyms: JK-1, JK1
BT330: 1.61 (log10 µM)
Synonyms: BT330
TCCSUP: 1.59 (log10 µM)
Synonyms: TCCSUP
Daoy: 1.58 (log10 µM)
Synonyms: Daoy, DAOY
SW1573: 1.53 (log10 µM)
Synonyms: SW1573, SW 1573, SW_1573
TYK-nu: 1.39 (log10 µM)
Synonyms: TYK-nu, TYKNU
U251MG: 1.36 (log10 µM)
Synonyms: U251MG
DEL: 1.34 (log10 µM)
Synonyms: DEL
DMS 454: 1.33 (log10 µM)
Synonyms: DMS 454, DMS_454, DMS454
SK-ES-1: 1.31 (log10 µM)
Synonyms: SK-ES-1, SKES1
NCI-H1581: 1.27 (log10 µM)
Synonyms: NCI-H1581, NCIH1581
OVCAR-5: 1.26 (log10 µM)
Synonyms: OVCAR-5, OVCAR5
GCT: 1.25 (log10 µM)
Synonyms: GCT
NCI-H2106: 1.24 (log10 µM)
Synonyms: NCI-H2106, NCIH2106
HOP-62: 1.21 (log10 µM)
Synonyms: HOP-62, HOP62
MDA-MB-453: 1.15 (log10 µM)
Synonyms: MDA-MB-453, MDAMB453, mdamb453
NCI-H1155: 1.15 (log10 µM)
Synonyms: NCI-H1155, NCIH1155
Saos-2: 1.14 (log10 µM)
Synonyms: Saos-2, SAOS2
KP-4: 1.13 (log10 µM)
Synonyms: KP-4, KP4
SF268: 1.04 (log10 µM)
Synonyms: SF268
HGC-27: 0.99 (log10 µM)
Synonyms: HGC-27, HGC27
SF539: 0.97 (log10 µM)
Synonyms: SF539
A204: 0.96 (log10 µM)
Synonyms: A204, A-204
AAC
pIC50
* Plot represents the top and bottom 30 data points
** Error Bars represent the Median Absolute Deviation
Download SVG
Download Data as CSV
PRL-3 Inhibitor I: AAC
AAC
Tissues
0.00
0.02
0.04
0.06
0.08
0.10
0.12
0.14
0.16
0.18
0.20
0.22
0.24
0.26
thyroid
thyroid
salivary_gland
salivary_gland
cervix
cervix
kidney
kidney
biliary_tract
biliary_tract
pleura
pleura
haematopoietic_and_lymphoid_tissue
haematopoietic_and_lymphoid_tissue
upper_aerodigestive_tract
upper_aerodigestive_tract
pancreas
pancreas
unknown
unknown
stomach
stomach
skin
skin
central_nervous_system
central_nervous_system
oesophagus
oesophagus
autonomic_ganglia
autonomic_ganglia
ovary
ovary
large_intestine
large_intestine
bone
bone
breast
breast
liver
liver
endometrium
endometrium
urinary_tract
urinary_tract
lung
lung
prostate
prostate
soft_tissue
soft_tissue
0.00
2.00
4.00
6.00
8.00
10.00
12.00
14.00
16.00
18.00
20.00
22.00
24.00
26.00
salivary_gland
salivary_gland
cervix
cervix
bone
bone
unknown
unknown
central_nervous_system
central_nervous_system
endometrium
endometrium
haematopoietic_and_lymphoid_tissue
haematopoietic_and_lymphoid_tissue
soft_tissue
soft_tissue
ovary
ovary
upper_aerodigestive_tract
upper_aerodigestive_tract
breast
breast
urinary_tract
urinary_tract
lung
lung
liver
liver
skin
skin
stomach
stomach
oesophagus
oesophagus
pancreas
pancreas
prostate
prostate
autonomic_ganglia
autonomic_ganglia
kidney
kidney
thyroid
thyroid
biliary_tract
biliary_tract
pleura
pleura
large_intestine
large_intestine
AAC
pIC50
= Truncated outliers
Download SVG
Top molecular features associated with response to PRL-3 Inhibitor I
Feature Type
Gene
Dataset
Tissue
Stat
Standardized
Coefficient
Nominal ANOVA
p-value
mRNA
PPP1R3D
CTRPv2
pan-cancer
AAC
0.12
0.003
mRNA
DCDC1
CTRPv2
pan-cancer
AAC
0.11
0.003
mRNA
TMEM63C
CTRPv2
pan-cancer
AAC
0.11
0.003
mRNA
RCOR3
CTRPv2
pan-cancer
AAC
0.12
0.003
mRNA
SYN1
CTRPv2
pan-cancer
AAC
0.11
0.003
mRNA
CDH8
CTRPv2
pan-cancer
AAC
0.11
0.003
mRNA
HRAS
CTRPv2
pan-cancer
AAC
0.12
0.003
mRNA
PCDHA10
CTRPv2
pan-cancer
AAC
0.12
0.004
mRNA
ARAF
CTRPv2
pan-cancer
AAC
0.11
0.004
mRNA
ARHGDIG
CTRPv2
pan-cancer
AAC
0.12
0.004
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