About
Documentation
Cite Us!
Github
Download
News
Explore
Batch Query
Search
Site
Home
About
Documentation
PharmacoGx
Cite Us!
Tools
Explore
Batch Query
Search
GitHub
Datatypes
datasets
cell lines
tissues
drugs
genes
experiments
Home
/
Compounds
/
KU 0060648
KU 0060648
Synonyms
Sources
Names Used
CTRPv2
KU 0060648
PharmacoGx
KU 0060648
External IDs
Database
Identifier
Smiles:
CCN1CCN(CC(=O)Nc2ccc(-c3cccc4c3oc(cc4=O)N3CCOCC3)c3sc4ccccc4c23)CC1
Annotated Targets
PRKDC
FDA Approval Status
Not Approved
Plots
Cell Line Summary
Tissue Summary
Molecular Features
Number of cell lines tested with KU
0060648 (per dataset)
0
100
200
300
400
500
600
700
800
# cell lines
CCLE
GDSC1000
gCSI
GRAY
FIMM
UHNBreast
CTRPv2
0
0
0
0
0
0
832
Download SVG
Number of tissues tested with KU 0060648
(per dataset)
0
2
4
6
8
10
12
14
16
18
20
22
24
# tissues
CCLE
GDSC1000
gCSI
GRAY
FIMM
UHNBreast
CTRPv2
0
0
0
0
0
0
25
Download SVG
Dataset Select
all
CTRPv2
KU 0060648: AAC
AAC
0.00
0.05
0.10
0.15
0.20
0.25
0.30
0.35
0.40
0.45
0.50
0.55
0.60
RI-1
RI-1
EoL-1-cell
EoL-1-cell
Pfeiffer
Pfeiffer
RS4;11
RS4;11
SU-DHL-6
SU-DHL-6
MDST8
MDST8
MV-4-11
MV-4-11
TUHR14TKB
TUHR14TKB
THP-1
THP-1
NCI-H1975
NCI-H1975
MM1-S
MM1-S
NU-DUL-1
NU-DUL-1
NCI-H1435
NCI-H1435
KASUMI-1
KASUMI-1
NOMO-1
NOMO-1
NALM-6
NALM-6
FU97
FU97
MOLM-16
MOLM-16
RH-41
RH-41
NCI-H929
NCI-H929
HCC-95
HCC-95
EBC-1
EBC-1
LoVo
LoVo
Hs 611.T
Hs 611.T
NCI-H747
NCI-H747
RCH-ACV
RCH-ACV
RPMI-8226
RPMI-8226
SEM
SEM
SW48
SW48
HCC-44
HCC-44
ES-2
ES-2
SW1783
SW1783
MKN45
MKN45
HS578BST
HS578BST
RERF-LC-Ad1
RERF-LC-Ad1
SK-MEL-3
SK-MEL-3
BT187
BT187
Hs 839.T
Hs 839.T
NCI-H2286
NCI-H2286
BT504
BT504
TOV-21G
TOV-21G
Hs 822.T
Hs 822.T
SK-MEL-2
SK-MEL-2
BT333
BT333
PSN1
PSN1
TE 441.T
TE 441.T
HeLa
HeLa
PLC-PRF-5
PLC-PRF-5
OV-90
OV-90
SF295
SF295
SK-MEL-5
SK-MEL-5
CJM
CJM
JHH-6
JHH-6
KMM-1
KMM-1
BT328
BT328
JL-1
JL-1
BT320
BT320
Calu-6
Calu-6
IA-LM
IA-LM
BT340
BT340
RI-1
EoL-1-cell
Pfeiffer
RS4;11
SU-DHL-6
MDST8
MV-4-11
TUHR14TKB
THP-1
NCI-H1975
MM1-S
NU-DUL-1
NCI-H1435
KASUMI-1
NOMO-1
NALM-6
FU97
MOLM-16
RH-41
NCI-H929
HCC-95
EBC-1
LoVo
Hs 611.T
NCI-H747
RCH-ACV
RPMI-8226
SEM
SW48
HCC-44
ES-2
SW1783
MKN45
HS578BST
RERF-LC-Ad1
SK-MEL-3
BT187
Hs 839.T
NCI-H2286
BT504
TOV-21G
Hs 822.T
SK-MEL-2
BT333
PSN1
TE 441.T
HeLa
PLC-PRF-5
OV-90
SF295
SK-MEL-5
CJM
JHH-6
KMM-1
BT328
JL-1
BT320
Calu-6
IA-LM
BT340
RI-1: 0.60
Synonyms: RI-1, RI1
EoL-1-cell: 0.57
Synonyms: EoL-1-cell, EOL-1, EOL1
Pfeiffer: 0.57
Synonyms: Pfeiffer, PFEIFFER
RS4;11: 0.52
Synonyms: RS4;11, RS4_11, RS4-11, RS411
SU-DHL-6: 0.51
Synonyms: SU-DHL-6, SUDHL6
MDST8: 0.51
Synonyms: MDST8
MV-4-11: 0.49
Synonyms: MV-4-11, MV411
TUHR14TKB: 0.49
Synonyms: TUHR14TKB
THP-1: 0.49
Synonyms: THP-1, THP1
NCI-H1975: 0.48
Synonyms: NCI-H1975, NCIH1975
MM1-S: 0.48
Synonyms: MM1-S, MM1S, MM.1S
NU-DUL-1: 0.47
Synonyms: NU-DUL-1, NUDUL1
NCI-H1435: 0.47
Synonyms: NCI-H1435, NCIH1435
KASUMI-1: 0.46
Synonyms: KASUMI-1, Kasumi-1, KASUMI1
NOMO-1: 0.46
Synonyms: NOMO-1, NOMO1
NALM-6: 0.46
Synonyms: NALM-6, NALM6
FU97: 0.45
Synonyms: FU97
MOLM-16: 0.45
Synonyms: MOLM-16, MOLM16
RH-41: 0.45
Synonyms: RH-41, RH41
NCI-H929: 0.44
Synonyms: NCI-H929, NCIH929
HCC-95: 0.44
Synonyms: HCC-95, HCC95
EBC-1: 0.44
Synonyms: EBC-1, EBC1
LoVo: 0.43
Synonyms: LoVo, LOVO
Hs 611.T: 0.42
Synonyms: Hs 611.T, Hs_611.T, HS611T
NCI-H747: 0.42
Synonyms: NCI-H747, NCIH747
RCH-ACV: 0.42
Synonyms: RCH-ACV, RCHACV
RPMI-8226: 0.42
Synonyms: RPMI-8226, RPMI 8226, RPMI_8226, RPMI8226
SEM: 0.41
Synonyms: SEM
SW48: 0.41
Synonyms: SW48, SW 48
HCC-44: 0.41
Synonyms: HCC-44, HCC44
: 0.00
Synonyms:
: 0.00
Synonyms:
: 0.00
Synonyms:
: 0.00
Synonyms:
: 0.00
Synonyms:
ES-2: 0.05
Synonyms: ES-2, ES2
SW1783: 0.05
Synonyms: SW1783, SW 1783, SW_1783
MKN45: 0.05
Synonyms: MKN45, MKN-45
HS578BST: 0.05
Synonyms: HS578BST
RERF-LC-Ad1: 0.05
Synonyms: RERF-LC-Ad1, RERFLCAD1
SK-MEL-3: 0.05
Synonyms: SK-MEL-3, SKMEL3
BT187: 0.05
Synonyms: BT187
Hs 839.T: 0.04
Synonyms: Hs 839.T, Hs_839.T, HS839T
NCI-H2286: 0.04
Synonyms: NCI-H2286, NCIH2286
BT504: 0.04
Synonyms: BT504
TOV-21G: 0.04
Synonyms: TOV-21G, TOV21G
Hs 822.T: 0.04
Synonyms: Hs 822.T, Hs_822.T, HS822T
SK-MEL-2: 0.04
Synonyms: SK-MEL-2, SKMEL2
BT333: 0.04
Synonyms: BT333
PSN1: 0.03
Synonyms: PSN1
TE 441.T: 0.03
Synonyms: TE 441.T, TE_441.T, TE-441-T, TE441T
HeLa: 0.03
Synonyms: HeLa, HELA
PLC-PRF-5: 0.03
Synonyms: PLC-PRF-5, PLC/PRF/5, PLC_PRF_5, PLCPRF5
OV-90: 0.03
Synonyms: OV-90, OV90
SF295: 0.03
Synonyms: SF295, SF-295
SK-MEL-5: 0.02
Synonyms: SK-MEL-5, SKMEL5
CJM: 0.02
Synonyms: CJM
JHH-6: 0.02
Synonyms: JHH-6, JHH6
KMM-1: 0.02
Synonyms: KMM-1, KMM1
BT328: 0.02
Synonyms: BT328
JL-1: 0.02
Synonyms: JL-1, JL1
BT320: 0.02
Synonyms: BT320
Calu-6: 0.01
Synonyms: Calu-6, CALU6
IA-LM: 0.01
Synonyms: IA-LM, IALM
BT340: 0.00
Synonyms: BT340
Download SVG
-1.00
-0.50
0.00
0.50
1.00
1.50
2.00
2.50
T-24
T-24
L-1236
L-1236
Hs 934.T
Hs 934.T
NCI-H460
NCI-H460
TT2609-C02
TT2609-C02
C32
C32
Calu-1
Calu-1
Calu-6
Calu-6
PC-3
PC-3
RT4
RT4
HD-MY-Z
HD-MY-Z
BT179
BT179
BT422
BT422
COLO-829
COLO-829
IA-LM
IA-LM
SNU-1272
SNU-1272
LS-123
LS-123
PSN1
PSN1
BT232
BT232
MDA-MB-435
MDA-MB-435
BT224
BT224
CJM
CJM
SF295
SF295
NCI-H524
NCI-H524
NCI-H2342
NCI-H2342
8-MG-BA
8-MG-BA
ES-2
ES-2
A253
A253
SNU-1066
SNU-1066
TOV-112D
TOV-112D
ASKA
ASKA
MDST8
MDST8
PL-21
PL-21
KHM-1B
KHM-1B
KARPAS-422
KARPAS-422
NCI-H1666
NCI-H1666
SNU-182
SNU-182
Hs 611.T
Hs 611.T
NCI-H747
NCI-H747
HCC-44
HCC-44
KMS-26
KMS-26
SEM
SEM
RCH-ACV
RCH-ACV
RPMI-8226
RPMI-8226
SW48
SW48
RH-41
RH-41
MOLM-16
MOLM-16
FU97
FU97
KASUMI-1
KASUMI-1
NOMO-1
NOMO-1
NALM-6
NALM-6
UO31
UO31
NU-DUL-1
NU-DUL-1
NCI-H1975
NCI-H1975
NCI-H929
NCI-H929
SU-DHL-6
SU-DHL-6
RS4;11
RS4;11
MV-4-11
MV-4-11
EoL-1-cell
EoL-1-cell
Pfeiffer
Pfeiffer
T-24
L-1236
Hs 934.T
NCI-H460
TT2609-C02
C32
Calu-1
Calu-6
PC-3
RT4
HD-MY-Z
BT179
BT422
COLO-829
IA-LM
SNU-1272
LS-123
PSN1
BT232
MDA-MB-435
BT224
CJM
SF295
NCI-H524
NCI-H2342
8-MG-BA
ES-2
A253
SNU-1066
TOV-112D
ASKA
MDST8
PL-21
KHM-1B
KARPAS-422
NCI-H1666
SNU-182
Hs 611.T
NCI-H747
HCC-44
KMS-26
SEM
RCH-ACV
RPMI-8226
SW48
RH-41
MOLM-16
FU97
KASUMI-1
NOMO-1
NALM-6
UO31
NU-DUL-1
NCI-H1975
NCI-H929
SU-DHL-6
RS4;11
MV-4-11
EoL-1-cell
Pfeiffer
T-24: 2.84 (log10 µM)
Synonyms: T-24, T24
L-1236: 2.62 (log10 µM)
Synonyms: L-1236, L1236
Hs 934.T: 2.49 (log10 µM)
Synonyms: Hs 934.T, Hs_934.T, HS934T
NCI-H460: 2.35 (log10 µM)
Synonyms: NCI-H460, NCIH460
TT2609-C02: 2.30 (log10 µM)
Synonyms: TT2609-C02, TT2609C02
C32: 2.17 (log10 µM)
Synonyms: C32
Calu-1: 2.15 (log10 µM)
Synonyms: Calu-1, CALU1
Calu-6: 2.15 (log10 µM)
Synonyms: Calu-6, CALU6
PC-3: 2.03 (log10 µM)
Synonyms: PC-3, PC3
RT4: 1.85 (log10 µM)
Synonyms: RT4
HD-MY-Z: 1.77 (log10 µM)
Synonyms: HD-MY-Z, HDMYZ
BT179: 1.76 (log10 µM)
Synonyms: BT179
BT422: 1.72 (log10 µM)
Synonyms: BT422
COLO-829: 1.67 (log10 µM)
Synonyms: COLO-829, COLO 829, COLO_829, COLO829
IA-LM: 1.66 (log10 µM)
Synonyms: IA-LM, IALM
SNU-1272: 1.65 (log10 µM)
Synonyms: SNU-1272, SNU1272
LS-123: 1.62 (log10 µM)
Synonyms: LS-123, LS123
PSN1: 1.59 (log10 µM)
Synonyms: PSN1
BT232: 1.54 (log10 µM)
Synonyms: BT232
MDA-MB-435: 1.54 (log10 µM)
Synonyms: MDA-MB-435, MDA-MB-435S, MDAMB435S
BT224: 1.54 (log10 µM)
Synonyms: BT224
CJM: 1.50 (log10 µM)
Synonyms: CJM
SF295: 1.49 (log10 µM)
Synonyms: SF295, SF-295
NCI-H524: 1.49 (log10 µM)
Synonyms: NCI-H524, NCIH524
NCI-H2342: 1.49 (log10 µM)
Synonyms: NCI-H2342, NCIH2342
8-MG-BA: 1.49 (log10 µM)
Synonyms: 8-MG-BA, 8MGBA
ES-2: 1.48 (log10 µM)
Synonyms: ES-2, ES2
A253: 1.48 (log10 µM)
Synonyms: A253, A-253
SNU-1066: 1.48 (log10 µM)
Synonyms: SNU-1066, SNU1066
TOV-112D: 1.47 (log10 µM)
Synonyms: TOV-112D, TOV112D
: 0.00 (log10 µM)
Synonyms:
: 0.00 (log10 µM)
Synonyms:
: 0.00 (log10 µM)
Synonyms:
: 0.00 (log10 µM)
Synonyms:
: 0.00 (log10 µM)
Synonyms:
ASKA: -0.23 (log10 µM)
Synonyms: ASKA
MDST8: -0.23 (log10 µM)
Synonyms: MDST8
PL-21: -0.23 (log10 µM)
Synonyms: PL-21, PL21
KHM-1B: -0.24 (log10 µM)
Synonyms: KHM-1B, KHM1B
KARPAS-422: -0.26 (log10 µM)
Synonyms: KARPAS-422, KARPAS422
NCI-H1666: -0.28 (log10 µM)
Synonyms: NCI-H1666, NCIH1666
SNU-182: -0.28 (log10 µM)
Synonyms: SNU-182, SNU182
Hs 611.T: -0.29 (log10 µM)
Synonyms: Hs 611.T, Hs_611.T, HS611T
NCI-H747: -0.31 (log10 µM)
Synonyms: NCI-H747, NCIH747
HCC-44: -0.32 (log10 µM)
Synonyms: HCC-44, HCC44
KMS-26: -0.33 (log10 µM)
Synonyms: KMS-26, KMS26
SEM: -0.34 (log10 µM)
Synonyms: SEM
RCH-ACV: -0.34 (log10 µM)
Synonyms: RCH-ACV, RCHACV
RPMI-8226: -0.34 (log10 µM)
Synonyms: RPMI-8226, RPMI 8226, RPMI_8226, RPMI8226
SW48: -0.38 (log10 µM)
Synonyms: SW48, SW 48
RH-41: -0.50 (log10 µM)
Synonyms: RH-41, RH41
MOLM-16: -0.50 (log10 µM)
Synonyms: MOLM-16, MOLM16
FU97: -0.52 (log10 µM)
Synonyms: FU97
KASUMI-1: -0.53 (log10 µM)
Synonyms: KASUMI-1, Kasumi-1, KASUMI1
NOMO-1: -0.54 (log10 µM)
Synonyms: NOMO-1, NOMO1
NALM-6: -0.54 (log10 µM)
Synonyms: NALM-6, NALM6
UO31: -0.59 (log10 µM)
Synonyms: UO31, UO-31, U031
NU-DUL-1: -0.61 (log10 µM)
Synonyms: NU-DUL-1, NUDUL1
NCI-H1975: -0.62 (log10 µM)
Synonyms: NCI-H1975, NCIH1975
NCI-H929: -0.65 (log10 µM)
Synonyms: NCI-H929, NCIH929
SU-DHL-6: -0.78 (log10 µM)
Synonyms: SU-DHL-6, SUDHL6
RS4;11: -0.89 (log10 µM)
Synonyms: RS4;11, RS4_11, RS4-11, RS411
MV-4-11: -0.89 (log10 µM)
Synonyms: MV-4-11, MV411
EoL-1-cell: -1.15 (log10 µM)
Synonyms: EoL-1-cell, EOL-1, EOL1
Pfeiffer: -1.17 (log10 µM)
Synonyms: Pfeiffer, PFEIFFER
AAC
pIC50
* Plot represents the top and bottom 30 data points
** Error Bars represent the Median Absolute Deviation
Download SVG
Download Data as CSV
KU 0060648: AAC
AAC
Tissues
0.05
0.10
0.15
0.20
0.25
0.30
0.35
0.40
0.45
0.50
0.55
0.60
cervix
cervix
unknown
unknown
central_nervous_system
central_nervous_system
pancreas
pancreas
skin
skin
soft_tissue
soft_tissue
oesophagus
oesophagus
endometrium
endometrium
ovary
ovary
kidney
kidney
thyroid
thyroid
liver
liver
lung
lung
urinary_tract
urinary_tract
pleura
pleura
breast
breast
upper_aerodigestive_tract
upper_aerodigestive_tract
biliary_tract
biliary_tract
bone
bone
prostate
prostate
large_intestine
large_intestine
stomach
stomach
autonomic_ganglia
autonomic_ganglia
haematopoietic_and_lymphoid_tissue
haematopoietic_and_lymphoid_tissue
salivary_gland
salivary_gland
-1.00
-0.50
0.00
0.50
1.00
1.50
2.00
salivary_gland
salivary_gland
haematopoietic_and_lymphoid_tissue
haematopoietic_and_lymphoid_tissue
stomach
stomach
prostate
prostate
autonomic_ganglia
autonomic_ganglia
bone
bone
biliary_tract
biliary_tract
upper_aerodigestive_tract
upper_aerodigestive_tract
urinary_tract
urinary_tract
large_intestine
large_intestine
oesophagus
oesophagus
breast
breast
soft_tissue
soft_tissue
liver
liver
lung
lung
endometrium
endometrium
ovary
ovary
pleura
pleura
cervix
cervix
thyroid
thyroid
pancreas
pancreas
kidney
kidney
central_nervous_system
central_nervous_system
skin
skin
unknown
unknown
AAC
pIC50
= Truncated outliers
Download SVG
Top molecular features associated with response to KU 0060648
Feature Type
Gene
Dataset
Tissue
Stat
Standardized
Coefficient
Nominal ANOVA
p-value
mRNA
CMSS1
CTRPv2
pan-cancer
AAC
-0.078
0.03
mRNA
CNN2
CTRPv2
pan-cancer
AAC
0.082
0.03
mRNA
ENPP1
CTRPv2
pan-cancer
AAC
-0.084
0.03
mRNA
PYHIN1
CTRPv2
pan-cancer
AAC
0.079
0.03
mRNA
ZNF3
CTRPv2
pan-cancer
AAC
0.078
0.03
mRNA
EXT1
CTRPv2
pan-cancer
AAC
-0.085
0.03
mRNA
CDCP1
CTRPv2
pan-cancer
AAC
-0.085
0.03
mRNA
RP11-296A16.1
CTRPv2
pan-cancer
AAC
0.078
0.03
mRNA
PLEKHG4
CTRPv2
pan-cancer
AAC
-0.079
0.03
mRNA
MRPS27
CTRPv2
pan-cancer
AAC
0.079
0.03
← Previous
1
2
…
169
170
171
…
199
200
Next →
Download CSV