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Compounds
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cyanoquinoline 11
cyanoquinoline 11
Synonyms
Sources
Names Used
CTRPv2
cyanoquinoline 11
PharmacoGx
cyanoquinoline 11
External IDs
Database
Identifier
Smiles:
Fc1ccc(Nc2c(cnc3c(Cl)cc(NCc4cnc[nH]4)cc23)C#N)cc1Cl
Annotated Targets
MAP3K8
FDA Approval Status
Not Approved
Plots
Cell Line Summary
Tissue Summary
Molecular Features
Number of cell lines tested with
cyanoquinoline 11 (per dataset)
0
50
100
150
200
250
300
350
400
# cell lines
CCLE
GDSC1000
gCSI
GRAY
FIMM
UHNBreast
CTRPv2
0
0
0
0
0
0
408
Download SVG
Number of tissues tested with
cyanoquinoline 11 (per dataset)
0
2
4
6
8
10
12
14
16
18
20
22
24
# tissues
CCLE
GDSC1000
gCSI
GRAY
FIMM
UHNBreast
CTRPv2
0
0
0
0
0
0
24
Download SVG
Dataset Select
all
CTRPv2
cyanoquinoline 11: AAC
AAC
0.00
0.05
0.10
0.15
0.20
0.25
0.30
0.35
HCC827
HCC827
PC-14
PC-14
YD-10B
YD-10B
NCI-H1435
NCI-H1435
SW1573
SW1573
LS-513
LS-513
KHM-1B
KHM-1B
NCI-H211
NCI-H211
SNU-182
SNU-182
DMS-79
DMS-79
NCI-H2087
NCI-H2087
HCC-1588
HCC-1588
SU-DHL-8
SU-DHL-8
PEER
PEER
NCI-H1666
NCI-H1666
MV-4-11
MV-4-11
SNU-478
SNU-478
CCK-81
CCK-81
U-2-OS
U-2-OS
JK-1
JK-1
OCUM-1
OCUM-1
KMS-34
KMS-34
RMG-I
RMG-I
A2780
A2780
SNU-466
SNU-466
SNU-1079
SNU-1079
ZR-75-1
ZR-75-1
RL95-2
RL95-2
NCI-H508
NCI-H508
SNU-886
SNU-886
SNU-410
SNU-410
SK-MEL-31
SK-MEL-31
SNU-489
SNU-489
LCLC-103H
LCLC-103H
MKN45
MKN45
ECC12
ECC12
SNU-1272
SNU-1272
BFTC-905
BFTC-905
SK-MEL-30
SK-MEL-30
NCI-H441
NCI-H441
DBTRG-05MG
DBTRG-05MG
GSU
GSU
HCC-1195
HCC-1195
LS-411N
LS-411N
NMC-G1
NMC-G1
U-87-MG
U-87-MG
NCI-H2172
NCI-H2172
ME-1
ME-1
SU.86.86
SU.86.86
TUHR4TKB
TUHR4TKB
ML-1
ML-1
HEC-265
HEC-265
KNS81
KNS81
CFPAC-1
CFPAC-1
NCI-H226
NCI-H226
COLO 201
COLO 201
SK-MEL-28
SK-MEL-28
SBC-5
SBC-5
TUHR10TKB
TUHR10TKB
Hs 936.T
Hs 936.T
HCC827
PC-14
YD-10B
NCI-H1435
SW1573
LS-513
KHM-1B
NCI-H211
SNU-182
DMS-79
NCI-H2087
HCC-1588
SU-DHL-8
PEER
NCI-H1666
MV-4-11
SNU-478
CCK-81
U-2-OS
JK-1
OCUM-1
KMS-34
RMG-I
A2780
SNU-466
SNU-1079
ZR-75-1
RL95-2
NCI-H508
SNU-886
SNU-410
SK-MEL-31
SNU-489
LCLC-103H
MKN45
ECC12
SNU-1272
BFTC-905
SK-MEL-30
NCI-H441
DBTRG-05MG
GSU
HCC-1195
LS-411N
NMC-G1
U-87-MG
NCI-H2172
ME-1
SU.86.86
TUHR4TKB
ML-1
HEC-265
KNS81
CFPAC-1
NCI-H226
COLO 201
SK-MEL-28
SBC-5
TUHR10TKB
Hs 936.T
HCC827: 0.35
Synonyms: HCC827, HCC-827
PC-14: 0.29
Synonyms: PC-14, PC14
YD-10B: 0.27
Synonyms: YD-10B, YD10B
NCI-H1435: 0.27
Synonyms: NCI-H1435, NCIH1435
SW1573: 0.26
Synonyms: SW1573, SW 1573, SW_1573
LS-513: 0.25
Synonyms: LS-513, LS513
KHM-1B: 0.25
Synonyms: KHM-1B, KHM1B
NCI-H211: 0.24
Synonyms: NCI-H211, NCIH211
SNU-182: 0.24
Synonyms: SNU-182, SNU182
DMS-79: 0.23
Synonyms: DMS-79, DMS 79, DMS_79, DMS79
NCI-H2087: 0.23
Synonyms: NCI-H2087, NCIH2087
HCC-1588: 0.23
Synonyms: HCC-1588, HCC1588
SU-DHL-8: 0.22
Synonyms: SU-DHL-8, SUDHL8
PEER: 0.22
Synonyms: PEER
NCI-H1666: 0.21
Synonyms: NCI-H1666, NCIH1666
MV-4-11: 0.21
Synonyms: MV-4-11, MV411
SNU-478: 0.21
Synonyms: SNU-478, SNU478
CCK-81: 0.21
Synonyms: CCK-81, CCK81
U-2-OS: 0.21
Synonyms: U-2-OS, U-2 OS, U-2_OS, U2OS
JK-1: 0.20
Synonyms: JK-1, JK1
OCUM-1: 0.20
Synonyms: OCUM-1, OCUM1
KMS-34: 0.20
Synonyms: KMS-34, KMS34
RMG-I: 0.20
Synonyms: RMG-I, RMGI
A2780: 0.20
Synonyms: A2780
SNU-466: 0.20
Synonyms: SNU-466, SNU466
SNU-1079: 0.19
Synonyms: SNU-1079, SNU1079
ZR-75-1: 0.19
Synonyms: ZR-75-1, ZR751, zr751
RL95-2: 0.19
Synonyms: RL95-2, RL952
NCI-H508: 0.19
Synonyms: NCI-H508, NCIH508
SNU-886: 0.19
Synonyms: SNU-886, SNU886
: 0.00
Synonyms:
: 0.00
Synonyms:
: 0.00
Synonyms:
: 0.00
Synonyms:
: 0.00
Synonyms:
SNU-410: 0.03
Synonyms: SNU-410, SNU410
SK-MEL-31: 0.03
Synonyms: SK-MEL-31, SKMEL31
SNU-489: 0.03
Synonyms: SNU-489, SNU489
LCLC-103H: 0.03
Synonyms: LCLC-103H, LCLC103H
MKN45: 0.02
Synonyms: MKN45, MKN-45
ECC12: 0.02
Synonyms: ECC12
SNU-1272: 0.02
Synonyms: SNU-1272, SNU1272
BFTC-905: 0.02
Synonyms: BFTC-905, BFTC905
SK-MEL-30: 0.02
Synonyms: SK-MEL-30, SKMEL30
NCI-H441: 0.02
Synonyms: NCI-H441, NCIH441
DBTRG-05MG: 0.02
Synonyms: DBTRG-05MG, DBTRG05MG
GSU: 0.02
Synonyms: GSU
HCC-1195: 0.02
Synonyms: HCC-1195, HCC1195
LS-411N: 0.02
Synonyms: LS-411N, LS411N
NMC-G1: 0.02
Synonyms: NMC-G1, NMCG1
U-87-MG: 0.02
Synonyms: U-87-MG, U-87 MG, U-87_MG, U87MG
NCI-H2172: 0.02
Synonyms: NCI-H2172, NCIH2172
ME-1: 0.02
Synonyms: ME-1, ME1
SU.86.86: 0.02
Synonyms: SU.86.86, SU8686
TUHR4TKB: 0.02
Synonyms: TUHR4TKB
ML-1: 0.02
Synonyms: ML-1, ML1
HEC-265: 0.02
Synonyms: HEC-265, HEC265
KNS81: 0.02
Synonyms: KNS81
CFPAC-1: 0.02
Synonyms: CFPAC-1, CFPAC1
NCI-H226: 0.01
Synonyms: NCI-H226, NCIH226
COLO 201: 0.01
Synonyms: COLO 201, COLO_201, COLO201
SK-MEL-28: 0.01
Synonyms: SK-MEL-28, SKMEL28
SBC-5: 0.01
Synonyms: SBC-5, SBC5
TUHR10TKB: 0.01
Synonyms: TUHR10TKB
Hs 936.T: 0.01
Synonyms: Hs 936.T, Hs_936.T, HS936T
Download SVG
0.00
0.50
1.00
1.50
2.00
2.50
3.00
3.50
4.00
SW1573
SW1573
TCC-PAN2
TCC-PAN2
RPMI-7951
RPMI-7951
NCI-H2052
NCI-H2052
HDQ-P1
HDQ-P1
SNU-61
SNU-61
RKO
RKO
OCUM-1
OCUM-1
NCI-H460
NCI-H460
NCI-H508
NCI-H508
NCI-H2122
NCI-H2122
NCI-H226
NCI-H226
VMRC-RCW
VMRC-RCW
A549
A549
ME-1
ME-1
KARPAS-620
KARPAS-620
Hs 936.T
Hs 936.T
BHT-101
BHT-101
KM12
KM12
NCI-H2172
NCI-H2172
HCC-1195
HCC-1195
EFE-184
EFE-184
LCLC-97TM1
LCLC-97TM1
KNS81
KNS81
Hey-A8
Hey-A8
NCI-H1792
NCI-H1792
SU.86.86
SU.86.86
NCI-H2228
NCI-H2228
MDST8
MDST8
A375
A375
LS 180
LS 180
HSC-4
HSC-4
RKN
RKN
SR-786
SR-786
NCI-H2087
NCI-H2087
PEER
PEER
OCI-AML2
OCI-AML2
A2780
A2780
SNU-478
SNU-478
MV-4-11
MV-4-11
YD-38
YD-38
SUP-T11
SUP-T11
KARPAS-299
KARPAS-299
SNU-1079
SNU-1079
AMO-1
AMO-1
Hs 852.T
Hs 852.T
KMS-34
KMS-34
ZR-75-1
ZR-75-1
NCI-H661
NCI-H661
SNU-182
SNU-182
NCI-H211
NCI-H211
HCC-1588
HCC-1588
LS-513
LS-513
SNU-C5
SNU-C5
NCI-H1666
NCI-H1666
RMG-I
RMG-I
CCK-81
CCK-81
NCI-H1435
NCI-H1435
PC-14
PC-14
YD-10B
YD-10B
SW1573
TCC-PAN2
RPMI-7951
NCI-H2052
HDQ-P1
SNU-61
RKO
OCUM-1
NCI-H460
NCI-H508
NCI-H2122
NCI-H226
VMRC-RCW
A549
ME-1
KARPAS-620
Hs 936.T
BHT-101
KM12
NCI-H2172
HCC-1195
EFE-184
LCLC-97TM1
KNS81
Hey-A8
NCI-H1792
SU.86.86
NCI-H2228
MDST8
A375
LS 180
HSC-4
RKN
SR-786
NCI-H2087
PEER
OCI-AML2
A2780
SNU-478
MV-4-11
YD-38
SUP-T11
KARPAS-299
SNU-1079
AMO-1
Hs 852.T
KMS-34
ZR-75-1
NCI-H661
SNU-182
NCI-H211
HCC-1588
LS-513
SNU-C5
NCI-H1666
RMG-I
CCK-81
NCI-H1435
PC-14
YD-10B
SW1573: 4.02 (log10 µM)
Synonyms: SW1573, SW 1573, SW_1573
TCC-PAN2: 4.00 (log10 µM)
Synonyms: TCC-PAN2, TCCPAN2
RPMI-7951: 3.68 (log10 µM)
Synonyms: RPMI-7951, RPMI7951
NCI-H2052: 3.24 (log10 µM)
Synonyms: NCI-H2052, NCIH2052
HDQ-P1: 3.04 (log10 µM)
Synonyms: HDQ-P1, HDQP1, hdqp1
SNU-61: 2.90 (log10 µM)
Synonyms: SNU-61, SNU61
RKO: 2.86 (log10 µM)
Synonyms: RKO
OCUM-1: 2.82 (log10 µM)
Synonyms: OCUM-1, OCUM1
NCI-H460: 2.65 (log10 µM)
Synonyms: NCI-H460, NCIH460
NCI-H508: 2.60 (log10 µM)
Synonyms: NCI-H508, NCIH508
NCI-H2122: 2.58 (log10 µM)
Synonyms: NCI-H2122, NCIH2122
NCI-H226: 2.55 (log10 µM)
Synonyms: NCI-H226, NCIH226
VMRC-RCW: 2.55 (log10 µM)
Synonyms: VMRC-RCW, VMRCRCW
A549: 2.48 (log10 µM)
Synonyms: A549
ME-1: 2.47 (log10 µM)
Synonyms: ME-1, ME1
KARPAS-620: 2.40 (log10 µM)
Synonyms: KARPAS-620, KARPAS620
Hs 936.T: 2.27 (log10 µM)
Synonyms: Hs 936.T, Hs_936.T, HS936T
BHT-101: 2.26 (log10 µM)
Synonyms: BHT-101, BHT101
KM12: 2.25 (log10 µM)
Synonyms: KM12, KM-12
NCI-H2172: 2.25 (log10 µM)
Synonyms: NCI-H2172, NCIH2172
HCC-1195: 2.24 (log10 µM)
Synonyms: HCC-1195, HCC1195
EFE-184: 2.23 (log10 µM)
Synonyms: EFE-184, EFE184
LCLC-97TM1: 2.21 (log10 µM)
Synonyms: LCLC-97TM1, LCLC97TM1
KNS81: 2.20 (log10 µM)
Synonyms: KNS81
Hey-A8: 2.18 (log10 µM)
Synonyms: Hey-A8, HEYA8
NCI-H1792: 2.18 (log10 µM)
Synonyms: NCI-H1792, NCIH1792
SU.86.86: 2.17 (log10 µM)
Synonyms: SU.86.86, SU8686
NCI-H2228: 2.16 (log10 µM)
Synonyms: NCI-H2228, NCIH2228
MDST8: 2.15 (log10 µM)
Synonyms: MDST8
A375: 2.15 (log10 µM)
Synonyms: A375, A-375
: 0.00 (log10 µM)
Synonyms:
: 0.00 (log10 µM)
Synonyms:
: 0.00 (log10 µM)
Synonyms:
: 0.00 (log10 µM)
Synonyms:
: 0.00 (log10 µM)
Synonyms:
LS 180: 1.19 (log10 µM)
Synonyms: LS 180, LS_180, LS-180, LS180
HSC-4: 1.19 (log10 µM)
Synonyms: HSC-4, HSC4
RKN: 1.19 (log10 µM)
Synonyms: RKN
SR-786: 1.18 (log10 µM)
Synonyms: SR-786, SR786
NCI-H2087: 1.18 (log10 µM)
Synonyms: NCI-H2087, NCIH2087
PEER: 1.18 (log10 µM)
Synonyms: PEER
OCI-AML2: 1.17 (log10 µM)
Synonyms: OCI-AML2, OCIAML2
A2780: 1.17 (log10 µM)
Synonyms: A2780
SNU-478: 1.17 (log10 µM)
Synonyms: SNU-478, SNU478
MV-4-11: 1.17 (log10 µM)
Synonyms: MV-4-11, MV411
YD-38: 1.17 (log10 µM)
Synonyms: YD-38, YD38
SUP-T11: 1.16 (log10 µM)
Synonyms: SUP-T11, SUPT11
KARPAS-299: 1.16 (log10 µM)
Synonyms: KARPAS-299, KARPAS299
SNU-1079: 1.14 (log10 µM)
Synonyms: SNU-1079, SNU1079
AMO-1: 1.13 (log10 µM)
Synonyms: AMO-1, AMO1
Hs 852.T: 1.13 (log10 µM)
Synonyms: Hs 852.T, Hs_852.T, HS852T
KMS-34: 1.10 (log10 µM)
Synonyms: KMS-34, KMS34
ZR-75-1: 1.09 (log10 µM)
Synonyms: ZR-75-1, ZR751, zr751
NCI-H661: 1.08 (log10 µM)
Synonyms: NCI-H661, NCIH661
SNU-182: 1.05 (log10 µM)
Synonyms: SNU-182, SNU182
NCI-H211: 1.05 (log10 µM)
Synonyms: NCI-H211, NCIH211
HCC-1588: 1.03 (log10 µM)
Synonyms: HCC-1588, HCC1588
LS-513: 1.01 (log10 µM)
Synonyms: LS-513, LS513
SNU-C5: 0.97 (log10 µM)
Synonyms: SNU-C5, SNUC5
NCI-H1666: 0.95 (log10 µM)
Synonyms: NCI-H1666, NCIH1666
RMG-I: 0.87 (log10 µM)
Synonyms: RMG-I, RMGI
CCK-81: 0.84 (log10 µM)
Synonyms: CCK-81, CCK81
NCI-H1435: 0.83 (log10 µM)
Synonyms: NCI-H1435, NCIH1435
PC-14: 0.74 (log10 µM)
Synonyms: PC-14, PC14
YD-10B: 0.72 (log10 µM)
Synonyms: YD-10B, YD10B
AAC
pIC50
* Plot represents the top and bottom 30 data points
** Error Bars represent the Median Absolute Deviation
Download SVG
Download Data as CSV
cyanoquinoline 11: AAC
AAC
Tissues
0.00
0.05
0.10
0.15
0.20
0.25
0.30
0.35
cervix
cervix
central_nervous_system
central_nervous_system
kidney
kidney
skin
skin
pancreas
pancreas
urinary_tract
urinary_tract
thyroid
thyroid
endometrium
endometrium
autonomic_ganglia
autonomic_ganglia
pleura
pleura
soft_tissue
soft_tissue
ovary
ovary
lung
lung
large_intestine
large_intestine
biliary_tract
biliary_tract
bone
bone
salivary_gland
salivary_gland
oesophagus
oesophagus
liver
liver
haematopoietic_and_lymphoid_tissue
haematopoietic_and_lymphoid_tissue
breast
breast
prostate
prostate
stomach
stomach
upper_aerodigestive_tract
upper_aerodigestive_tract
0.60
0.80
1.00
1.20
1.40
1.60
cervix
cervix
salivary_gland
salivary_gland
upper_aerodigestive_tract
upper_aerodigestive_tract
liver
liver
oesophagus
oesophagus
stomach
stomach
breast
breast
prostate
prostate
biliary_tract
biliary_tract
haematopoietic_and_lymphoid_tissue
haematopoietic_and_lymphoid_tissue
lung
lung
bone
bone
thyroid
thyroid
soft_tissue
soft_tissue
large_intestine
large_intestine
central_nervous_system
central_nervous_system
autonomic_ganglia
autonomic_ganglia
ovary
ovary
pancreas
pancreas
endometrium
endometrium
pleura
pleura
urinary_tract
urinary_tract
skin
skin
kidney
kidney
AAC
pIC50
= Truncated outliers
Download SVG
Top molecular features associated with response to cyanoquinoline 11
Feature Type
Gene
Dataset
Tissue
Stat
Standardized
Coefficient
Nominal ANOVA
p-value
mRNA
SH3YL1
CTRPv2
pan-cancer
AAC
0.16
0.006
mRNA
PDE7B
CTRPv2
pan-cancer
AAC
-0.14
0.006
mRNA
CDRT15
CTRPv2
pan-cancer
AAC
0.14
0.006
mRNA
COX18
CTRPv2
pan-cancer
AAC
0.15
0.006
mRNA
APLP2
CTRPv2
pan-cancer
AAC
-0.16
0.006
mRNA
PLD6
CTRPv2
pan-cancer
AAC
0.15
0.006
mRNA
GPC2
CTRPv2
pan-cancer
AAC
0.17
0.007
mRNA
DEFB103A
CTRPv2
pan-cancer
AAC
0.14
0.007
mRNA
LTA4H
CTRPv2
pan-cancer
AAC
-0.14
0.007
mRNA
PI4KB
CTRPv2
pan-cancer
AAC
0.14
0.007
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