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GSK2126458

Synonyms

SourcesNames Used
GDSC1000, GRAYGSK2126458
PharmacoGx GSK2126458

External IDs

DatabaseIdentifier
Smiles: COC1=C(C=C(C=N1)C2=CC3=C(C=CN=C3C=C2)C4=CN=NC=C4)NS(=O)(=O)C5=C(C=C(C=C5)F)F
Inchikey: CGBJSGAELGCMKE-UHFFFAOYSA-N
Pubchem: 25167777

Annotated Targets

MTOR, PIK3CA, PIK3CB, PIK3CD, PIK3CG

FDA Approval Status

Not Approved
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Top molecular features associated with response to GSK2126458


Feature TypeStandardized
Nominal ANOVA
mRNA SH2D4B GDSC1000 pan-cancer AAC 0.099 0.001
mRNA PIK3R1 GDSC1000 pan-cancer AAC 0.11 0.001
mRNA KDM5B GDSC1000 pan-cancer AAC 0.11 0.001
mRNA LDLRAD4 GDSC1000 pan-cancer AAC 0.12 0.001
mRNA DPP9 GDSC1000 pan-cancer AAC -0.1 0.001
mRNA ZNF345 GDSC1000 pan-cancer AAC 0.11 0.001
mRNA ATAD5 GDSC1000 pan-cancer AAC 0.11 0.001
mRNA CNRIP1 GDSC1000 pan-cancer AAC -0.14 0.001
mRNA MLF1 GDSC1000 pan-cancer AAC -0.12 0.001
mRNA GNMT GDSC1000 pan-cancer AAC 0.1 0.001
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