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Compounds
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narciclasine
narciclasine
Synonyms
Sources
Names Used
CTRPv2
narciclasine
PharmacoGx
narciclasine
External IDs
Database
Identifier
Smiles:
C1OC2=C(O1)C(=C3C(=C2)C4=CC(C(C(C4NC3=O)O)O)O)O
Inchikey:
LZAZURSABQIKGB-AEKGRLRDSA-N
Pubchem:
72376
Annotated Targets
RHOA
FDA Approval Status
Not Approved
Plots
Cell Line Summary
Tissue Summary
Molecular Features
Number of cell lines tested with
narciclasine (per dataset)
0
100
200
300
400
500
600
700
800
# cell lines
CCLE
GDSC1000
gCSI
GRAY
FIMM
UHNBreast
CTRPv2
0
0
0
0
0
0
812
Download SVG
Number of tissues tested with narciclasine
(per dataset)
0
2
4
6
8
10
12
14
16
18
20
22
24
# tissues
CCLE
GDSC1000
gCSI
GRAY
FIMM
UHNBreast
CTRPv2
0
0
0
0
0
0
25
Download SVG
Dataset Select
all
CTRPv2
narciclasine: AAC
AAC
0.00
0.10
0.20
0.30
0.40
0.50
0.60
0.70
0.80
SKM-1
SKM-1
NU-DUL-1
NU-DUL-1
EoL-1-cell
EoL-1-cell
MOLM-6
MOLM-6
MOLM-16
MOLM-16
MOLT-16
MOLT-16
BCP-1
BCP-1
GA-10
GA-10
Pfeiffer
Pfeiffer
RS4;11
RS4;11
KMS-34
KMS-34
Daudi
Daudi
KMS-12-BM
KMS-12-BM
MV-4-11
MV-4-11
SU-DHL-6
SU-DHL-6
697
697
MHH-CALL-4
MHH-CALL-4
SU-DHL-4
SU-DHL-4
L-540
L-540
DU-4475
DU-4475
SU-DHL-8
SU-DHL-8
TE-6
TE-6
SUP-M2
SUP-M2
MOLT-13
MOLT-13
Set-2
Set-2
BV-173
BV-173
ECC10
ECC10
SIG-M5
SIG-M5
U-2-OS
U-2-OS
SNU-16
SNU-16
SK-MEL-24
SK-MEL-24
SNU-1272
SNU-1272
BT320
BT320
SNU-503
SNU-503
SNU-1077
SNU-1077
KNS-42
KNS-42
HS578BST
HS578BST
OE19
OE19
RCC10RGB
RCC10RGB
Hs 934.T
Hs 934.T
PK-45H
PK-45H
KMRC-2
KMRC-2
Caki-2
Caki-2
MKN45
MKN45
IA-LM
IA-LM
Hep G2
Hep G2
REC-1
REC-1
NCI-H2126
NCI-H2126
BL-41
BL-41
KMM-1
KMM-1
SW1783
SW1783
Toledo
Toledo
SK-MEL-31
SK-MEL-31
SNU-201
SNU-201
CAKI-1
CAKI-1
KP-N-YN
KP-N-YN
MC116
MC116
KARPAS-620
KARPAS-620
TUHR14TKB
TUHR14TKB
U-CH1
U-CH1
SKM-1
NU-DUL-1
EoL-1-cell
MOLM-6
MOLM-16
MOLT-16
BCP-1
GA-10
Pfeiffer
RS4;11
KMS-34
Daudi
KMS-12-BM
MV-4-11
SU-DHL-6
697
MHH-CALL-4
SU-DHL-4
L-540
DU-4475
SU-DHL-8
TE-6
SUP-M2
MOLT-13
Set-2
BV-173
ECC10
SIG-M5
U-2-OS
SNU-16
SK-MEL-24
SNU-1272
BT320
SNU-503
SNU-1077
KNS-42
HS578BST
OE19
RCC10RGB
Hs 934.T
PK-45H
KMRC-2
Caki-2
MKN45
IA-LM
Hep G2
REC-1
NCI-H2126
BL-41
KMM-1
SW1783
Toledo
SK-MEL-31
SNU-201
CAKI-1
KP-N-YN
MC116
KARPAS-620
TUHR14TKB
U-CH1
SKM-1: 0.82
Synonyms: SKM-1, SKM1
NU-DUL-1: 0.82
Synonyms: NU-DUL-1, NUDUL1
EoL-1-cell: 0.82
Synonyms: EoL-1-cell, EOL-1, EOL1
MOLM-6: 0.80
Synonyms: MOLM-6, MOLM6
MOLM-16: 0.80
Synonyms: MOLM-16, MOLM16
MOLT-16: 0.78
Synonyms: MOLT-16, MOLT16
BCP-1: 0.78
Synonyms: BCP-1, BCP1
GA-10: 0.77
Synonyms: GA-10, GA10
Pfeiffer: 0.77
Synonyms: Pfeiffer, PFEIFFER
RS4;11: 0.77
Synonyms: RS4;11, RS4_11, RS4-11, RS411
KMS-34: 0.76
Synonyms: KMS-34, KMS34
Daudi: 0.76
Synonyms: Daudi, DAUDI
KMS-12-BM: 0.76
Synonyms: KMS-12-BM, KMS12BM
MV-4-11: 0.76
Synonyms: MV-4-11, MV411
SU-DHL-6: 0.76
Synonyms: SU-DHL-6, SUDHL6
697: 0.76
Synonyms: 697
MHH-CALL-4: 0.75
Synonyms: MHH-CALL-4, MHHCALL4
SU-DHL-4: 0.75
Synonyms: SU-DHL-4, SUDHL4
L-540: 0.75
Synonyms: L-540, L540
DU-4475: 0.73
Synonyms: DU-4475, DU4475, du4475
SU-DHL-8: 0.73
Synonyms: SU-DHL-8, SUDHL8
TE-6: 0.73
Synonyms: TE-6, TE6
SUP-M2: 0.73
Synonyms: SUP-M2, SUPM2
MOLT-13: 0.73
Synonyms: MOLT-13, MOLT13
Set-2: 0.73
Synonyms: Set-2, Set2, SET-2, SET2
BV-173: 0.73
Synonyms: BV-173, BV173
ECC10: 0.72
Synonyms: ECC10
SIG-M5: 0.72
Synonyms: SIG-M5, SIGM5
U-2-OS: 0.72
Synonyms: U-2-OS, U-2 OS, U-2_OS, U2OS
SNU-16: 0.72
Synonyms: SNU-16, SNU16
: 0.00
Synonyms:
: 0.00
Synonyms:
: 0.00
Synonyms:
: 0.00
Synonyms:
: 0.00
Synonyms:
SK-MEL-24: 0.20
Synonyms: SK-MEL-24, SKMEL24
SNU-1272: 0.19
Synonyms: SNU-1272, SNU1272
BT320: 0.18
Synonyms: BT320
SNU-503: 0.18
Synonyms: SNU-503, SNU503
SNU-1077: 0.18
Synonyms: SNU-1077, SNU1077
KNS-42: 0.18
Synonyms: KNS-42, KNS42
HS578BST: 0.18
Synonyms: HS578BST
OE19: 0.18
Synonyms: OE19
RCC10RGB: 0.18
Synonyms: RCC10RGB
Hs 934.T: 0.17
Synonyms: Hs 934.T, Hs_934.T, HS934T
PK-45H: 0.17
Synonyms: PK-45H, PK45H
KMRC-2: 0.16
Synonyms: KMRC-2, KMRC2
Caki-2: 0.16
Synonyms: Caki-2, CAKI2
MKN45: 0.15
Synonyms: MKN45, MKN-45
IA-LM: 0.14
Synonyms: IA-LM, IALM
Hep G2: 0.12
Synonyms: Hep G2, Hep_G2, HEPG2
REC-1: 0.12
Synonyms: REC-1, REC1
NCI-H2126: 0.11
Synonyms: NCI-H2126, NCIH2126
BL-41: 0.10
Synonyms: BL-41, BL41
KMM-1: 0.08
Synonyms: KMM-1, KMM1
SW1783: 0.07
Synonyms: SW1783, SW 1783, SW_1783
Toledo: 0.07
Synonyms: Toledo, TOLEDO
SK-MEL-31: 0.06
Synonyms: SK-MEL-31, SKMEL31
SNU-201: 0.06
Synonyms: SNU-201, SNU201
CAKI-1: 0.06
Synonyms: CAKI-1, Caki-1, CAKI1
KP-N-YN: 0.05
Synonyms: KP-N-YN, KPNYN
MC116: 0.04
Synonyms: MC116
KARPAS-620: 0.02
Synonyms: KARPAS-620, KARPAS620
TUHR14TKB: 0.02
Synonyms: TUHR14TKB
U-CH1: 0.01
Synonyms: U-CH1
Download SVG
-2.00
-1.00
0.00
1.00
2.00
3.00
4.00
Toledo
Toledo
HS578BST
HS578BST
IA-LM
IA-LM
BT320
BT320
Caki-2
Caki-2
SNU-1077
SNU-1077
PK-45H
PK-45H
RCC10RGB
RCC10RGB
SNU-201
SNU-201
T98G
T98G
KNS-42
KNS-42
OV-90
OV-90
KNS81
KNS81
Hs 934.T
Hs 934.T
Hs 895.T
Hs 895.T
KMRC-2
KMRC-2
HCC1419
HCC1419
U-87-MG
U-87-MG
Hs 822.T
Hs 822.T
ZR-75-30
ZR-75-30
NCI-H660
NCI-H660
NCI-H1793
NCI-H1793
VMRC-RCZ
VMRC-RCZ
MG-63
MG-63
SNU-1272
SNU-1272
BT-474
BT-474
SK-MEL-24
SK-MEL-24
HCC1937
HCC1937
MKN1
MKN1
KP-2
KP-2
L-540
L-540
Set-2
Set-2
MHH-CALL-4
MHH-CALL-4
SUP-B15
SUP-B15
SU-DHL-6
SU-DHL-6
SU-DHL-4
SU-DHL-4
SU-DHL-10
SU-DHL-10
OCUM-1
OCUM-1
OCI-LY3
OCI-LY3
SUP-M2
SUP-M2
KMS-12-BM
KMS-12-BM
EB1
EB1
CW-2
CW-2
BV-173
BV-173
DU-4475
DU-4475
SU-DHL-8
SU-DHL-8
697
697
MV-4-11
MV-4-11
Pfeiffer
Pfeiffer
GA-10
GA-10
MOLT-16
MOLT-16
KMS-34
KMS-34
Daudi
Daudi
ECC10
ECC10
RI-1
RI-1
BCP-1
BCP-1
EoL-1-cell
EoL-1-cell
MOLM-16
MOLM-16
SKM-1
SKM-1
NU-DUL-1
NU-DUL-1
Toledo
HS578BST
IA-LM
BT320
Caki-2
SNU-1077
PK-45H
RCC10RGB
SNU-201
T98G
KNS-42
OV-90
KNS81
Hs 934.T
Hs 895.T
KMRC-2
HCC1419
U-87-MG
Hs 822.T
ZR-75-30
NCI-H660
NCI-H1793
VMRC-RCZ
MG-63
SNU-1272
BT-474
SK-MEL-24
HCC1937
MKN1
KP-2
L-540
Set-2
MHH-CALL-4
SUP-B15
SU-DHL-6
SU-DHL-4
SU-DHL-10
OCUM-1
OCI-LY3
SUP-M2
KMS-12-BM
EB1
CW-2
BV-173
DU-4475
SU-DHL-8
697
MV-4-11
Pfeiffer
GA-10
MOLT-16
KMS-34
Daudi
ECC10
RI-1
BCP-1
EoL-1-cell
MOLM-16
SKM-1
NU-DUL-1
Toledo: 4.56 (log10 µM)
Synonyms: Toledo, TOLEDO
HS578BST: 3.87 (log10 µM)
Synonyms: HS578BST
IA-LM: 2.65 (log10 µM)
Synonyms: IA-LM, IALM
BT320: 1.82 (log10 µM)
Synonyms: BT320
Caki-2: 1.76 (log10 µM)
Synonyms: Caki-2, CAKI2
SNU-1077: 1.48 (log10 µM)
Synonyms: SNU-1077, SNU1077
PK-45H: 1.39 (log10 µM)
Synonyms: PK-45H, PK45H
RCC10RGB: 1.39 (log10 µM)
Synonyms: RCC10RGB
SNU-201: 1.36 (log10 µM)
Synonyms: SNU-201, SNU201
T98G: 1.22 (log10 µM)
Synonyms: T98G
KNS-42: 1.19 (log10 µM)
Synonyms: KNS-42, KNS42
OV-90: 1.07 (log10 µM)
Synonyms: OV-90, OV90
KNS81: 1.05 (log10 µM)
Synonyms: KNS81
Hs 934.T: 0.97 (log10 µM)
Synonyms: Hs 934.T, Hs_934.T, HS934T
Hs 895.T: 0.96 (log10 µM)
Synonyms: Hs 895.T, Hs_895.T, HS895T
KMRC-2: 0.91 (log10 µM)
Synonyms: KMRC-2, KMRC2
HCC1419: 0.85 (log10 µM)
Synonyms: HCC1419, hcc1419
U-87-MG: 0.84 (log10 µM)
Synonyms: U-87-MG, U-87 MG, U-87_MG, U87MG
Hs 822.T: 0.80 (log10 µM)
Synonyms: Hs 822.T, Hs_822.T, HS822T
ZR-75-30: 0.80 (log10 µM)
Synonyms: ZR-75-30, ZR7530, zr7530
NCI-H660: 0.75 (log10 µM)
Synonyms: NCI-H660, NCIH660
NCI-H1793: 0.69 (log10 µM)
Synonyms: NCI-H1793, NCIH1793
VMRC-RCZ: 0.66 (log10 µM)
Synonyms: VMRC-RCZ, VMRCRCZ
MG-63: 0.66 (log10 µM)
Synonyms: MG-63, MG63
SNU-1272: 0.62 (log10 µM)
Synonyms: SNU-1272, SNU1272
BT-474: 0.62 (log10 µM)
Synonyms: BT-474, BT474, bt474
SK-MEL-24: 0.61 (log10 µM)
Synonyms: SK-MEL-24, SKMEL24
HCC1937: 0.58 (log10 µM)
Synonyms: HCC1937, hcc1937
MKN1: 0.54 (log10 µM)
Synonyms: MKN1, MKN-1
KP-2: 0.53 (log10 µM)
Synonyms: KP-2, KP2
: 0.00 (log10 µM)
Synonyms:
: 0.00 (log10 µM)
Synonyms:
: 0.00 (log10 µM)
Synonyms:
: 0.00 (log10 µM)
Synonyms:
: 0.00 (log10 µM)
Synonyms:
L-540: -1.92 (log10 µM)
Synonyms: L-540, L540
Set-2: -1.92 (log10 µM)
Synonyms: Set-2, Set2, SET-2, SET2
MHH-CALL-4: -1.93 (log10 µM)
Synonyms: MHH-CALL-4, MHHCALL4
SUP-B15: -1.94 (log10 µM)
Synonyms: SUP-B15, SUPB15
SU-DHL-6: -1.97 (log10 µM)
Synonyms: SU-DHL-6, SUDHL6
SU-DHL-4: -1.97 (log10 µM)
Synonyms: SU-DHL-4, SUDHL4
SU-DHL-10: -1.98 (log10 µM)
Synonyms: SU-DHL-10, SUDHL10
OCUM-1: -1.98 (log10 µM)
Synonyms: OCUM-1, OCUM1
OCI-LY3: -1.99 (log10 µM)
Synonyms: OCI-LY3, OCI-LY-3, OCILY3
SUP-M2: -2.00 (log10 µM)
Synonyms: SUP-M2, SUPM2
KMS-12-BM: -2.00 (log10 µM)
Synonyms: KMS-12-BM, KMS12BM
EB1: -2.02 (log10 µM)
Synonyms: EB1
CW-2: -2.03 (log10 µM)
Synonyms: CW-2, CW2
BV-173: -2.05 (log10 µM)
Synonyms: BV-173, BV173
DU-4475: -2.06 (log10 µM)
Synonyms: DU-4475, DU4475, du4475
SU-DHL-8: -2.06 (log10 µM)
Synonyms: SU-DHL-8, SUDHL8
697: -2.06 (log10 µM)
Synonyms: 697
MV-4-11: -2.08 (log10 µM)
Synonyms: MV-4-11, MV411
Pfeiffer: -2.10 (log10 µM)
Synonyms: Pfeiffer, PFEIFFER
GA-10: -2.11 (log10 µM)
Synonyms: GA-10, GA10
MOLT-16: -2.11 (log10 µM)
Synonyms: MOLT-16, MOLT16
KMS-34: -2.12 (log10 µM)
Synonyms: KMS-34, KMS34
Daudi: -2.12 (log10 µM)
Synonyms: Daudi, DAUDI
ECC10: -2.15 (log10 µM)
Synonyms: ECC10
RI-1: -2.15 (log10 µM)
Synonyms: RI-1, RI1
BCP-1: -2.16 (log10 µM)
Synonyms: BCP-1, BCP1
EoL-1-cell: -2.20 (log10 µM)
Synonyms: EoL-1-cell, EOL-1, EOL1
MOLM-16: -2.21 (log10 µM)
Synonyms: MOLM-16, MOLM16
SKM-1: -2.24 (log10 µM)
Synonyms: SKM-1, SKM1
NU-DUL-1: -2.25 (log10 µM)
Synonyms: NU-DUL-1, NUDUL1
AAC
pIC50
* Plot represents the top and bottom 30 data points
** Error Bars represent the Median Absolute Deviation
Download SVG
Download Data as CSV
narciclasine: AAC
AAC
Tissues
0.00
0.10
0.20
0.30
0.40
0.50
0.60
0.70
0.80
kidney
kidney
liver
liver
central_nervous_system
central_nervous_system
pancreas
pancreas
breast
breast
prostate
prostate
ovary
ovary
biliary_tract
biliary_tract
pleura
pleura
skin
skin
lung
lung
urinary_tract
urinary_tract
thyroid
thyroid
cervix
cervix
oesophagus
oesophagus
endometrium
endometrium
upper_aerodigestive_tract
upper_aerodigestive_tract
stomach
stomach
unknown
unknown
soft_tissue
soft_tissue
large_intestine
large_intestine
bone
bone
salivary_gland
salivary_gland
autonomic_ganglia
autonomic_ganglia
haematopoietic_and_lymphoid_tissue
haematopoietic_and_lymphoid_tissue
-2.00
-1.50
-1.00
-0.50
0.00
0.50
1.00
1.50
2.00
2.50
3.00
haematopoietic_and_lymphoid_tissue
haematopoietic_and_lymphoid_tissue
autonomic_ganglia
autonomic_ganglia
large_intestine
large_intestine
salivary_gland
salivary_gland
stomach
stomach
soft_tissue
soft_tissue
bone
bone
biliary_tract
biliary_tract
endometrium
endometrium
unknown
unknown
lung
lung
thyroid
thyroid
upper_aerodigestive_tract
upper_aerodigestive_tract
oesophagus
oesophagus
ovary
ovary
prostate
prostate
urinary_tract
urinary_tract
pancreas
pancreas
cervix
cervix
pleura
pleura
breast
breast
skin
skin
central_nervous_system
central_nervous_system
liver
liver
kidney
kidney
AAC
pIC50
= Truncated outliers
Download SVG
Top molecular features associated with response to narciclasine
Feature Type
Gene
Dataset
Tissue
Stat
Standardized
Coefficient
Nominal ANOVA
p-value
mRNA
HIST1H2AC
CTRPv2
pan-cancer
AAC
-0.085
0.008
mRNA
CLDN25
CTRPv2
pan-cancer
AAC
-0.087
0.008
mRNA
SLC45A3
CTRPv2
pan-cancer
AAC
0.095
0.008
mRNA
ING5
CTRPv2
pan-cancer
AAC
0.094
0.008
mRNA
ARHGAP23
CTRPv2
pan-cancer
AAC
-0.092
0.008
mRNA
MAD2L1
CTRPv2
pan-cancer
AAC
0.09
0.008
mRNA
C16orf59
CTRPv2
pan-cancer
AAC
0.09
0.008
mRNA
PHB2
CTRPv2
pan-cancer
AAC
0.089
0.008
mRNA
PTPRJ
CTRPv2
pan-cancer
AAC
-0.095
0.008
mRNA
SLC12A8
CTRPv2
pan-cancer
AAC
-0.088
0.008
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