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GSK1070916

Synonyms

SourcesNames Used
GDSC1000, GRAYGSK1070916
PharmacoGx GSK1070916

External IDs

DatabaseIdentifier
Smiles: CCN1C=C(C(=N1)C2=CC=C(C=C2)NC(=O)N(C)C)C3=C4C=C(NC4=NC=C3)C5=CC(=CC=C5)CN(C)C
Inchikey: QTBWCSQGBMPECM-UHFFFAOYSA-N
Pubchem: 46885626

Annotated Targets

AURKA, AURKB, AURKC, CYP2D6, CYP3A4

FDA Approval Status

Not Approved
Dataset Select
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Top molecular features associated with response to GSK1070916


Feature TypeStandardized
Nominal ANOVA
mRNA NFKB2 GDSC1000 pan-cancer AAC -0.19 1e-09
mRNA ZNF227 GDSC1000 pan-cancer AAC 0.2 2e-09
mRNA PIP4K2C GDSC1000 pan-cancer AAC -0.22 2e-09
mRNA TRAT1 GDSC1000 pan-cancer AAC 0.19 2e-09
mRNA CHAF1A GDSC1000 pan-cancer AAC 0.21 2e-09
mRNA SYTL2 GDSC1000 pan-cancer AAC -0.21 2e-09
mRNA HTATSF1 GDSC1000 pan-cancer AAC 0.19 2e-09
mRNA LMO2 GDSC1000 pan-cancer AAC 0.21 2e-09
mRNA FAM174A GDSC1000 pan-cancer AAC -0.2 2e-09
mRNA CAPN2 GDSC1000 pan-cancer AAC -0.25 2e-09
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