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Compounds
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GSK1070916
GSK1070916
Synonyms
Sources
Names Used
GDSC1000
,
GRAY
GSK1070916
PharmacoGx
GSK1070916
External IDs
Database
Identifier
Smiles:
CCN1C=C(C(=N1)C2=CC=C(C=C2)NC(=O)N(C)C)C3=C4C=C(NC4=NC=C3)C5=CC(=CC=C5)CN(C)C
Inchikey:
QTBWCSQGBMPECM-UHFFFAOYSA-N
Pubchem:
46885626
Annotated Targets
AURKA
,
AURKB
,
AURKC
,
CYP2D6
,
CYP3A4
FDA Approval Status
Not Approved
Plots
Cell Line Summary
Tissue Summary
Molecular Features
Number of cell lines tested with
GSK1070916 (per dataset)
0
100
200
300
400
500
600
700
800
900
# cell lines
CCLE
gCSI
FIMM
CTRPv2
UHNBreast
GRAY
GDSC1000
0
0
0
0
0
54
984
Download SVG
Number of tissues tested with
GSK1070916 (per dataset)
0
5
10
15
20
25
30
35
# tissues
CCLE
gCSI
FIMM
CTRPv2
UHNBreast
GRAY
GDSC1000
0
0
0
0
0
1
35
Download SVG
Dataset Select
all
GDSC1000
GRAY
GSK1070916: AAC
AAC
0.00
0.10
0.20
0.30
0.40
0.50
0.60
0.70
0.80
0.90
P30-OHK
P30-OHK
697
697
RS4;11
RS4;11
BL-70
BL-70
OCI-LY-19
OCI-LY-19
P12-ICHIKAWA
P12-ICHIKAWA
ES8
ES8
ALL-SIL
ALL-SIL
CCRF-CEM
CCRF-CEM
KE-37
KE-37
RH-1
RH-1
LOUCY
LOUCY
NALM-6
NALM-6
IMR-5
IMR-5
BV-173
BV-173
NCI-H524
NCI-H524
NCI-H847
NCI-H847
NCI-H2227
NCI-H2227
SU-DHL-10
SU-DHL-10
MV-4-11
MV-4-11
HUTU-80
HUTU-80
MOLM-13
MOLM-13
PF-382
PF-382
NCI-H2171
NCI-H2171
MOLT-13
MOLT-13
SU-DHL-5
SU-DHL-5
ST486
ST486
KOPN-8
KOPN-8
BPH-1
BPH-1
ES7
ES7
GMS-10
GMS-10
NCI-H23
NCI-H23
TMK-1
TMK-1
MRK-nu-1
MRK-nu-1
Hs 766T
Hs 766T
RC-K8
RC-K8
EKVX
EKVX
C3A
C3A
NCI-H345
NCI-H345
SK-MEL-1
SK-MEL-1
SBC-5
SBC-5
NCI-H441
NCI-H441
M14
M14
MKL-1-subclone-2
MKL-1-subclone-2
TE-9
TE-9
NCI-H1623
NCI-H1623
NCI-H1793
NCI-H1793
TE-4
TE-4
NCI-H64
NCI-H64
SK-MEL-28
SK-MEL-28
NCI-H1651
NCI-H1651
SW13
SW13
LoVo
LoVo
SW756
SW756
TT
TT
IOSE-397
IOSE-397
BFTC-909
BFTC-909
BICR 22
BICR 22
DMS-53
DMS-53
YMB-1-E
YMB-1-E
P30-OHK
697
RS4;11
BL-70
OCI-LY-19
P12-ICHIKAWA
ES8
ALL-SIL
CCRF-CEM
KE-37
RH-1
LOUCY
NALM-6
IMR-5
BV-173
NCI-H524
NCI-H847
NCI-H2227
SU-DHL-10
MV-4-11
HUTU-80
MOLM-13
PF-382
NCI-H2171
MOLT-13
SU-DHL-5
ST486
KOPN-8
BPH-1
ES7
GMS-10
NCI-H23
TMK-1
MRK-nu-1
Hs 766T
RC-K8
EKVX
C3A
NCI-H345
SK-MEL-1
SBC-5
NCI-H441
M14
MKL-1-subclone-2
TE-9
NCI-H1623
NCI-H1793
TE-4
NCI-H64
SK-MEL-28
NCI-H1651
SW13
LoVo
SW756
TT
IOSE-397
BFTC-909
BICR 22
DMS-53
YMB-1-E
P30-OHK: 0.97
Synonyms: P30-OHK
697: 0.96
Synonyms: 697
RS4;11: 0.93
Synonyms: RS4;11, RS4_11, RS4-11, RS411
BL-70: 0.93
Synonyms: BL-70, BL70
OCI-LY-19: 0.93
Synonyms: OCI-LY-19, OCILY19
P12-ICHIKAWA: 0.92
Synonyms: P12-ICHIKAWA, P12ICHIKAWA
ES8: 0.91
Synonyms: ES8
ALL-SIL: 0.90
Synonyms: ALL-SIL, ALLSIL
CCRF-CEM: 0.89
Synonyms: CCRF-CEM, CCRFCEM
KE-37: 0.89
Synonyms: KE-37, KE37
RH-1: 0.88
Synonyms: RH-1
LOUCY: 0.87
Synonyms: LOUCY, Loucy
NALM-6: 0.87
Synonyms: NALM-6, NALM6
IMR-5: 0.87
Synonyms: IMR-5
BV-173: 0.87
Synonyms: BV-173, BV173
NCI-H524: 0.84
Synonyms: NCI-H524, NCIH524
NCI-H847: 0.83
Synonyms: NCI-H847
NCI-H2227: 0.83
Synonyms: NCI-H2227
SU-DHL-10: 0.81
Synonyms: SU-DHL-10, SUDHL10
MV-4-11: 0.80
Synonyms: MV-4-11, MV411
HUTU-80: 0.80
Synonyms: HUTU-80, HuTu 80, HuTu_80
MOLM-13: 0.79
Synonyms: MOLM-13, MOLM13
PF-382: 0.78
Synonyms: PF-382, PF382
NCI-H2171: 0.78
Synonyms: NCI-H2171, NCIH2171
MOLT-13: 0.77
Synonyms: MOLT-13, MOLT13
SU-DHL-5: 0.76
Synonyms: SU-DHL-5
ST486: 0.75
Synonyms: ST486
KOPN-8: 0.75
Synonyms: KOPN-8
BPH-1: 0.75
Synonyms: BPH-1
ES7: 0.75
Synonyms: ES7
: 0.00
Synonyms:
: 0.00
Synonyms:
: 0.00
Synonyms:
: 0.00
Synonyms:
: 0.00
Synonyms:
GMS-10: 0.00
Synonyms: GMS-10, GMS10
NCI-H23: 0.00
Synonyms: NCI-H23, NCIH23
TMK-1: 0.00
Synonyms: TMK-1
MRK-nu-1: 0.00
Synonyms: MRK-nu-1
Hs 766T: 0.00
Synonyms: Hs 766T, Hs_766T, Hs-766T, Hs766T, HS766T
RC-K8: 0.00
Synonyms: RC-K8
EKVX: 0.00
Synonyms: EKVX
C3A: 0.00
Synonyms: C3A
NCI-H345: 0.00
Synonyms: NCI-H345
SK-MEL-1: 0.00
Synonyms: SK-MEL-1, SKMEL1
SBC-5: 0.00
Synonyms: SBC-5, SBC5
NCI-H441: 0.00
Synonyms: NCI-H441, NCIH441
M14: 0.00
Synonyms: M14
MKL-1-subclone-2: 0.00
Synonyms: MKL-1-subclone-2
TE-9: 0.00
Synonyms: TE-9, TE9
NCI-H1623: 0.00
Synonyms: NCI-H1623, NCIH1623
NCI-H1793: 0.00
Synonyms: NCI-H1793, NCIH1793
TE-4: 0.00
Synonyms: TE-4, TE4
NCI-H64: 0.00
Synonyms: NCI-H64
SK-MEL-28: 0.00
Synonyms: SK-MEL-28, SKMEL28
NCI-H1651: 0.00
Synonyms: NCI-H1651, NCIH1651
SW13: 0.00
Synonyms: SW13
LoVo: 0.00
Synonyms: LoVo, LOVO
SW756: 0.00
Synonyms: SW756
TT: 0.00
Synonyms: TT
IOSE-397: 0.00
Synonyms: IOSE-397
BFTC-909: 0.00
Synonyms: BFTC-909, BFTC909
BICR 22: 0.00
Synonyms: BICR 22, BICR_22, BICR22
DMS-53: 0.00
Synonyms: DMS-53, DMS 53, DMS_53, DMS53
YMB-1-E: 0.00
Synonyms: YMB-1-E
Download SVG
-5.00
0.00
5.00
10.00
15.00
20.00
25.00
30.00
LS-123
LS-123
H290
H290
NCI-H1385
NCI-H1385
NCI-H2085
NCI-H2085
COR-L279
COR-L279
SNU-475
SNU-475
OVKATE
OVKATE
NCI-H69
NCI-H69
NCI-H1522
NCI-H1522
OMC-1
OMC-1
MKN28
MKN28
ACN
ACN
RCM-1
RCM-1
WM278
WM278
NUGC-4
NUGC-4
GCIY
GCIY
Hs 940.T
Hs 940.T
COLO-684
COLO-684
COR-L88
COR-L88
TE-10
TE-10
NCI-H196
NCI-H196
MES-SA
MES-SA
EFM-19
EFM-19
H2591
H2591
SF268
SF268
NCI-H522
NCI-H522
DOK
DOK
Panc 08.13
Panc 08.13
C-33-A
C-33-A
OVCA433
OVCA433
KE-37
KE-37
RPMI-8402
RPMI-8402
ST486
ST486
KOPN-8
KOPN-8
P30-OHK
P30-OHK
IST-SL1
IST-SL1
BL-41
BL-41
HUTU-80
HUTU-80
MHH-ES-1
MHH-ES-1
NALM-6
NALM-6
MOLT-4
MOLT-4
ML-2
ML-2
697
697
ALL-SIL
ALL-SIL
NCI-H2171
NCI-H2171
P12-ICHIKAWA
P12-ICHIKAWA
BL-70
BL-70
REH
REH
KARPAS-45
KARPAS-45
SU-DHL-5
SU-DHL-5
NCI-H847
NCI-H847
LOUCY
LOUCY
NCI-H524
NCI-H524
ES8
ES8
OCI-LY-19
OCI-LY-19
RS4;11
RS4;11
PF-382
PF-382
EW-18
EW-18
SU-DHL-16
SU-DHL-16
COR-L311
COR-L311
LS-123
H290
NCI-H1385
NCI-H2085
COR-L279
SNU-475
OVKATE
NCI-H69
NCI-H1522
OMC-1
MKN28
ACN
RCM-1
WM278
NUGC-4
GCIY
Hs 940.T
COLO-684
COR-L88
TE-10
NCI-H196
MES-SA
EFM-19
H2591
SF268
NCI-H522
DOK
Panc 08.13
C-33-A
OVCA433
KE-37
RPMI-8402
ST486
KOPN-8
P30-OHK
IST-SL1
BL-41
HUTU-80
MHH-ES-1
NALM-6
MOLT-4
ML-2
697
ALL-SIL
NCI-H2171
P12-ICHIKAWA
BL-70
REH
KARPAS-45
SU-DHL-5
NCI-H847
LOUCY
NCI-H524
ES8
OCI-LY-19
RS4;11
PF-382
EW-18
SU-DHL-16
COR-L311
LS-123: 29.91 (log10 µM)
Synonyms: LS-123, LS123
H290: 29.18 (log10 µM)
Synonyms: H290
NCI-H1385: 27.74 (log10 µM)
Synonyms: NCI-H1385, NCIH1385
NCI-H2085: 21.13 (log10 µM)
Synonyms: NCI-H2085, NCIH2085
COR-L279: 21.03 (log10 µM)
Synonyms: COR-L279, CORL279
SNU-475: 16.75 (log10 µM)
Synonyms: SNU-475, SNU475
OVKATE: 15.75 (log10 µM)
Synonyms: OVKATE
NCI-H69: 14.90 (log10 µM)
Synonyms: NCI-H69, NCIH69
NCI-H1522: 10.55 (log10 µM)
Synonyms: NCI-H1522
OMC-1: 9.33 (log10 µM)
Synonyms: OMC-1
MKN28: 9.08 (log10 µM)
Synonyms: MKN28
ACN: 8.68 (log10 µM)
Synonyms: ACN
RCM-1: 8.40 (log10 µM)
Synonyms: RCM-1, RCM1
WM278: 8.28 (log10 µM)
Synonyms: WM278
NUGC-4: 7.76 (log10 µM)
Synonyms: NUGC-4, NUGC4
GCIY: 7.70 (log10 µM)
Synonyms: GCIY
Hs 940.T: 7.60 (log10 µM)
Synonyms: Hs 940.T, Hs_940.T, Hs-940-T, Hs940-T, HS940T
COLO-684: 7.35 (log10 µM)
Synonyms: COLO-684, COLO 684, COLO_684, COLO684
COR-L88: 7.20 (log10 µM)
Synonyms: COR-L88, CORL88
TE-10: 6.97 (log10 µM)
Synonyms: TE-10, TE10
NCI-H196: 6.95 (log10 µM)
Synonyms: NCI-H196, NCIH196
MES-SA: 6.89 (log10 µM)
Synonyms: MES-SA, MESSA
EFM-19: 6.82 (log10 µM)
Synonyms: EFM-19, EFM19, efm19
H2591: 6.71 (log10 µM)
Synonyms: H2591
SF268: 6.49 (log10 µM)
Synonyms: SF268
NCI-H522: 6.33 (log10 µM)
Synonyms: NCI-H522, NCIH522
DOK: 6.15 (log10 µM)
Synonyms: DOK
Panc 08.13: 6.14 (log10 µM)
Synonyms: Panc 08.13, Panc_08.13, PANC-08-13, PANC0813
C-33-A: 6.11 (log10 µM)
Synonyms: C-33-A, C-33 A
OVCA433: 6.03 (log10 µM)
Synonyms: OVCA433
: 0.00 (log10 µM)
Synonyms:
: 0.00 (log10 µM)
Synonyms:
: 0.00 (log10 µM)
Synonyms:
: 0.00 (log10 µM)
Synonyms:
: 0.00 (log10 µM)
Synonyms:
KE-37: -2.23 (log10 µM)
Synonyms: KE-37, KE37
RPMI-8402: -2.27 (log10 µM)
Synonyms: RPMI-8402, RPMI8402
ST486: -2.30 (log10 µM)
Synonyms: ST486
KOPN-8: -2.38 (log10 µM)
Synonyms: KOPN-8
P30-OHK: -2.49 (log10 µM)
Synonyms: P30-OHK
IST-SL1: -2.62 (log10 µM)
Synonyms: IST-SL1
BL-41: -2.72 (log10 µM)
Synonyms: BL-41, BL41
HUTU-80: -3.40 (log10 µM)
Synonyms: HUTU-80, HuTu 80, HuTu_80
MHH-ES-1: -3.58 (log10 µM)
Synonyms: MHH-ES-1, MHHES1
NALM-6: -3.63 (log10 µM)
Synonyms: NALM-6, NALM6
MOLT-4: -3.77 (log10 µM)
Synonyms: MOLT-4
ML-2: -3.81 (log10 µM)
Synonyms: ML-2, ML2
697: -4.06 (log10 µM)
Synonyms: 697
ALL-SIL: -4.90 (log10 µM)
Synonyms: ALL-SIL, ALLSIL
NCI-H2171: -5.06 (log10 µM)
Synonyms: NCI-H2171, NCIH2171
P12-ICHIKAWA: -5.32 (log10 µM)
Synonyms: P12-ICHIKAWA, P12ICHIKAWA
BL-70: -5.40 (log10 µM)
Synonyms: BL-70, BL70
REH: -5.71 (log10 µM)
Synonyms: REH, Reh
KARPAS-45: -5.83 (log10 µM)
Synonyms: KARPAS-45
SU-DHL-5: -5.84 (log10 µM)
Synonyms: SU-DHL-5
NCI-H847: -5.88 (log10 µM)
Synonyms: NCI-H847
LOUCY: -5.92 (log10 µM)
Synonyms: LOUCY, Loucy
NCI-H524: -5.95 (log10 µM)
Synonyms: NCI-H524, NCIH524
ES8: -5.98 (log10 µM)
Synonyms: ES8
OCI-LY-19: -5.98 (log10 µM)
Synonyms: OCI-LY-19, OCILY19
RS4;11: -5.98 (log10 µM)
Synonyms: RS4;11, RS4_11, RS4-11, RS411
PF-382: -6.00 (log10 µM)
Synonyms: PF-382, PF382
EW-18: -6.00 (log10 µM)
Synonyms: EW-18
SU-DHL-16: -6.00 (log10 µM)
Synonyms: SU-DHL-16
COR-L311: -6.00 (log10 µM)
Synonyms: COR-L311
AAC
pIC50
* Plot represents the top and bottom 30 data points
** Error Bars represent the Median Absolute Deviation
Download SVG
Download Data as CSV
GSK1070916: AAC
AAC
Tissues
0.00
0.10
0.20
0.30
0.40
0.50
0.60
0.70
0.80
0.90
adrenal_gland
adrenal_gland
neuroblastoma
neuroblastoma
placenta
placenta
oral_cavity
oral_cavity
testis
testis
thyroid
thyroid
pleura
pleura
kidney
kidney
liver
liver
other
other
urinary_tract
urinary_tract
skin
skin
gastrointestinal_tract_(site_indeterminate)
gastrointestinal_tract_(site_indeterminate)
stomach
stomach
oesophagus
oesophagus
upper_aerodigestive_tract
upper_aerodigestive_tract
cervix
cervix
pancreas
pancreas
vulva
vulva
central_nervous_system
central_nervous_system
soft_tissue
soft_tissue
endometrium
endometrium
ovary
ovary
misc
misc
head_and_neck
head_and_neck
large_intestine
large_intestine
breast
breast
lung
lung
biliary_tract
biliary_tract
salivary_gland
salivary_gland
prostate
prostate
autonomic_ganglia
autonomic_ganglia
bone
bone
haematopoietic_and_lymphoid_tissue
haematopoietic_and_lymphoid_tissue
small_intestine
small_intestine
-6.00
-4.00
-2.00
0.00
2.00
4.00
6.00
8.00
10.00
small_intestine
small_intestine
prostate
prostate
urinary_tract
urinary_tract
haematopoietic_and_lymphoid_tissue
haematopoietic_and_lymphoid_tissue
bone
bone
oral_cavity
oral_cavity
gastrointestinal_tract_(site_indeterminate)
gastrointestinal_tract_(site_indeterminate)
neuroblastoma
neuroblastoma
placenta
placenta
adrenal_gland
adrenal_gland
salivary_gland
salivary_gland
misc
misc
autonomic_ganglia
autonomic_ganglia
testis
testis
liver
liver
large_intestine
large_intestine
breast
breast
soft_tissue
soft_tissue
other
other
oesophagus
oesophagus
thyroid
thyroid
lung
lung
kidney
kidney
ovary
ovary
central_nervous_system
central_nervous_system
pancreas
pancreas
vulva
vulva
endometrium
endometrium
pleura
pleura
skin
skin
upper_aerodigestive_tract
upper_aerodigestive_tract
biliary_tract
biliary_tract
head_and_neck
head_and_neck
stomach
stomach
cervix
cervix
AAC
pIC50
= Truncated outliers
Download SVG
Top molecular features associated with response to GSK1070916
Feature Type
Gene
Dataset
Tissue
Stat
Standardized
Coefficient
Nominal ANOVA
p-value
mRNA
PRKX
GDSC1000
pan-cancer
AAC
0.21
2e-10
mRNA
VANGL2
GDSC1000
pan-cancer
AAC
0.21
2e-10
mRNA
TRA2B
GDSC1000
pan-cancer
AAC
0.22
2e-10
mRNA
THOC2
GDSC1000
pan-cancer
AAC
0.21
2e-10
mRNA
LAMB2
GDSC1000
pan-cancer
AAC
-0.25
2e-10
mRNA
ACVR2B
GDSC1000
pan-cancer
AAC
0.21
2e-10
mRNA
VMP1
GDSC1000
pan-cancer
AAC
-0.22
2e-10
mRNA
DNA2
GDSC1000
pan-cancer
AAC
0.22
2e-10
mRNA
CD96
GDSC1000
pan-cancer
AAC
0.21
2e-10
mRNA
CCDC14
GDSC1000
pan-cancer
AAC
0.2
2e-10
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