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GSK1070916

Synonyms

SourcesNames Used
GDSC1000, GRAYGSK1070916
PharmacoGx GSK1070916

External IDs

DatabaseIdentifier
Smiles: CCN1C=C(C(=N1)C2=CC=C(C=C2)NC(=O)N(C)C)C3=C4C=C(NC4=NC=C3)C5=CC(=CC=C5)CN(C)C
Inchikey: QTBWCSQGBMPECM-UHFFFAOYSA-N
Pubchem: 46885626

Annotated Targets

AURKA, AURKB, AURKC, CYP2D6, CYP3A4

FDA Approval Status

Not Approved
Dataset Select
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Top molecular features associated with response to GSK1070916


Feature TypeStandardized
Nominal ANOVA
mRNA LDLRAD4 GDSC1000 pan-cancer AAC 0.26 1e-12
mRNA CRABP1 GDSC1000 pan-cancer AAC 0.24 1e-12
mRNA SEPT6 GDSC1000 pan-cancer AAC 0.32 1e-12
mRNA KLHL23 GDSC1000 pan-cancer AAC 0.25 1e-12
mRNA H2AFY GDSC1000 pan-cancer AAC 0.23 1e-12
mRNA REEP5 GDSC1000 pan-cancer AAC -0.23 2e-12
mRNA RASGRP2 GDSC1000 pan-cancer AAC 0.3 2e-12
mRNA RBM10 GDSC1000 pan-cancer AAC 0.23 2e-12
mRNA SRSF7 GDSC1000 pan-cancer AAC 0.24 2e-12
mRNA PLEKHO1 GDSC1000 pan-cancer AAC 0.25 2e-12
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