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GSK1070916

Synonyms

SourcesNames Used
GDSC1000, GRAYGSK1070916
PharmacoGx GSK1070916

External IDs

DatabaseIdentifier
Smiles: CCN1C=C(C(=N1)C2=CC=C(C=C2)NC(=O)N(C)C)C3=C4C=C(NC4=NC=C3)C5=CC(=CC=C5)CN(C)C
Inchikey: QTBWCSQGBMPECM-UHFFFAOYSA-N
Pubchem: 46885626

Annotated Targets

AURKA, AURKB, AURKC, CYP2D6, CYP3A4

FDA Approval Status

Not Approved
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Top molecular features associated with response to GSK1070916


Feature TypeStandardized
Nominal ANOVA
mRNA RBMX GDSC1000 pan-cancer AAC 0.35 9e-25
mRNA MYB GDSC1000 pan-cancer AAC 0.45 2e-23
mRNA BAHCC1 GDSC1000 pan-cancer AAC 0.3 6e-22
mRNA BCL11B GDSC1000 pan-cancer AAC 0.31 1e-21
mRNA TTF1 GDSC1000 pan-cancer AAC 0.3 3e-21
mRNA MEX3A GDSC1000 pan-cancer AAC 0.33 7e-21
mRNA SQSTM1 GDSC1000 pan-cancer AAC -0.32 2e-20
mRNA PDS5B GDSC1000 pan-cancer AAC 0.31 3e-19
mRNA JARID2 GDSC1000 pan-cancer AAC 0.31 3e-19
mRNA ATOX1 GDSC1000 pan-cancer AAC -0.3 4e-19
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