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AEW541

AEW541

Synonyms

Sources	Names Used
CCLE	AEW541
PharmacoGx	AEW541

External IDs

Database	Identifier
Smiles:	C1CN(C1)CC2CC(C2)N3C=C(C4=C3N=CN=C4N)C5=CC(=CC=C5)OCC6=CC=CC=C6
Inchikey:	AECDBHGVIIRMOI-UHFFFAOYSA-N
Pubchem:	11476171

Annotated Targets

FDA Approval Status

Not Approved

Dataset Select

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Top molecular features associated with response to AEW541

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	GPX3	CCLE	pan-cancer	AAC	0.12	0.02
mRNA	BTBD17	CCLE	pan-cancer	AAC	-0.11	0.02
mRNA	RNF6	CCLE	pan-cancer	AAC	-0.12	0.02
mRNA	PLCB1	CCLE	pan-cancer	AAC	0.11	0.02
mRNA	CAPN7	CCLE	pan-cancer	AAC	0.11	0.02
mRNA	FOXO6	CCLE	pan-cancer	AAC	0.12	0.02
mRNA	NAIF1	CCLE	pan-cancer	AAC	0.12	0.02
mRNA	IFIT5	CCLE	pan-cancer	AAC	-0.12	0.02
mRNA	PSMB5	CCLE	pan-cancer	AAC	0.12	0.02
mRNA	PDIK1L	CCLE	pan-cancer	AAC	0.13	0.02

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