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OSI-906

OSI-906

Synonyms

Sources	Names Used
CTRPv2	linsitinib
PharmacoGx	OSI-906

External IDs

Database	Identifier
Smiles:	CC1(CC(C1)C2=NC(=C3N2C=CN=C3N)C4=CC5=C(C=C4)C=CC(=N5)C6=CC=CC=C6)O
Inchikey:	PKCDDUHJAFVJJB-UHFFFAOYSA-N
Pubchem:	11640390

FDA Approval Status

Not Approved

Dataset Select

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Top molecular features associated with response to OSI-906

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	CASP10	CTRPv2	pan-cancer	AAC	0.31	3e-16
mRNA	JCHAIN	CTRPv2	pan-cancer	AAC	0.29	4e-16
mRNA	ASB16	CTRPv2	pan-cancer	AAC	0.29	4e-16
mRNA	HRASLS2	CTRPv2	pan-cancer	AAC	0.27	5e-16
mRNA	IL6R	CTRPv2	pan-cancer	AAC	0.29	6e-16
mRNA	CLN6	CTRPv2	pan-cancer	AAC	0.28	7e-16
mRNA	CORO7	CTRPv2	pan-cancer	AAC	0.35	2e-15
mRNA	ITM2C	CTRPv2	pan-cancer	AAC	0.28	2e-15
mRNA	ST3GAL6	CTRPv2	pan-cancer	AAC	0.29	3e-15
mRNA	FAM46C	CTRPv2	pan-cancer	AAC	0.28	5e-15

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