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OSI-906

OSI-906

Synonyms

Sources	Names Used
CTRPv2	linsitinib
PharmacoGx	OSI-906

External IDs

Database	Identifier
Smiles:	CC1(CC(C1)C2=NC(=C3N2C=CN=C3N)C4=CC5=C(C=C4)C=CC(=N5)C6=CC=CC=C6)O
Inchikey:	PKCDDUHJAFVJJB-UHFFFAOYSA-N
Pubchem:	11640390

FDA Approval Status

Not Approved

Dataset Select

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Top molecular features associated with response to OSI-906

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	TRIM5	CTRPv2	pan-cancer	AAC	-0.18	9e-07
mRNA	JSRP1	CTRPv2	pan-cancer	AAC	0.19	9e-07
mRNA	ERN1	CTRPv2	pan-cancer	AAC	0.17	1e-06
mRNA	STAM2	CTRPv2	pan-cancer	AAC	-0.18	1e-06
mRNA	HERPUD1	CTRPv2	pan-cancer	AAC	0.17	1e-06
mRNA	TIMM13	CTRPv2	pan-cancer	AAC	0.18	1e-06
mRNA	C21orf91	CTRPv2	pan-cancer	AAC	0.18	1e-06
mRNA	SBK2	CTRPv2	pan-cancer	AAC	0.18	1e-06
mRNA	H1FX	CTRPv2	pan-cancer	AAC	0.18	1e-06
mRNA	CBWD2	CTRPv2	pan-cancer	AAC	0.17	1e-06

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