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OSI-906

OSI-906

Synonyms

Sources	Names Used
CTRPv2	linsitinib
PharmacoGx	OSI-906

External IDs

Database	Identifier
Smiles:	CC1(CC(C1)C2=NC(=C3N2C=CN=C3N)C4=CC5=C(C=C4)C=CC(=N5)C6=CC=CC=C6)O
Inchikey:	PKCDDUHJAFVJJB-UHFFFAOYSA-N
Pubchem:	11640390

FDA Approval Status

Not Approved

Dataset Select

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Top molecular features associated with response to OSI-906

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	FAM185A	CTRPv2	pan-cancer	AAC	0.18	2e-07
mRNA	ACTB	CTRPv2	pan-cancer	AAC	-0.19	2e-07
mRNA	MAP2K7	CTRPv2	pan-cancer	AAC	0.21	2e-07
mRNA	CTD-3148I10.9	CTRPv2	pan-cancer	AAC	0.21	2e-07
mRNA	STATH	CTRPv2	pan-cancer	AAC	0.18	2e-07
mRNA	KIR3DL1	CTRPv2	pan-cancer	AAC	0.18	2e-07
mRNA	RRAS2	CTRPv2	pan-cancer	AAC	-0.2	2e-07
mRNA	SLC37A4	CTRPv2	pan-cancer	AAC	0.19	3e-07
mRNA	ALDH16A1	CTRPv2	pan-cancer	AAC	0.2	3e-07
mRNA	VPS51	CTRPv2	pan-cancer	AAC	0.2	3e-07

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