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OSI-906

OSI-906

Synonyms

Sources	Names Used
CTRPv2	linsitinib
PharmacoGx	OSI-906

External IDs

Database	Identifier
Smiles:	CC1(CC(C1)C2=NC(=C3N2C=CN=C3N)C4=CC5=C(C=C4)C=CC(=N5)C6=CC=CC=C6)O
Inchikey:	PKCDDUHJAFVJJB-UHFFFAOYSA-N
Pubchem:	11640390

FDA Approval Status

Not Approved

Dataset Select

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Top molecular features associated with response to OSI-906

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	ZXDC	CTRPv2	pan-cancer	AAC	0.16	8e-06
mRNA	ZSCAN26	CTRPv2	pan-cancer	AAC	-0.12	0.0009
mRNA	ZP3	CTRPv2	pan-cancer	AAC	0.12	0.0007
mRNA	ZNRF1	CTRPv2	pan-cancer	AAC	-0.11	0.002
mRNA	ZNHIT2	CTRPv2	pan-cancer	AAC	0.21	4e-09
mRNA	ZNFX1	CTRPv2	pan-cancer	AAC	-0.12	0.002
mRNA	ZNF891	CTRPv2	pan-cancer	AAC	0.12	0.002
mRNA	ZNF791	CTRPv2	pan-cancer	AAC	0.15	1e-05
mRNA	ZNF79	CTRPv2	pan-cancer	AAC	0.11	0.002
mRNA	ZNF786	CTRPv2	pan-cancer	AAC	0.11	0.003

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