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OSI-906

OSI-906

Synonyms

Sources	Names Used
CTRPv2	linsitinib
PharmacoGx	OSI-906

External IDs

Database	Identifier
Smiles:	CC1(CC(C1)C2=NC(=C3N2C=CN=C3N)C4=CC5=C(C=C4)C=CC(=N5)C6=CC=CC=C6)O
Inchikey:	PKCDDUHJAFVJJB-UHFFFAOYSA-N
Pubchem:	11640390

FDA Approval Status

Not Approved

Dataset Select

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Top molecular features associated with response to OSI-906

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	PMVK	CTRPv2	pan-cancer	AAC	0.31	5e-18
mRNA	ENAM	CTRPv2	pan-cancer	AAC	0.31	6e-18
mRNA	SLC25A20	CTRPv2	pan-cancer	AAC	0.31	4e-17
mRNA	CASP10	CTRPv2	pan-cancer	AAC	0.31	3e-16
mRNA	ARHGAP45	CTRPv2	pan-cancer	AAC	0.31	1e-09
mRNA	ITGB7	CTRPv2	pan-cancer	AAC	0.3	4e-19
mRNA	ARHGAP4	CTRPv2	pan-cancer	AAC	0.3	5e-10
mRNA	DERL3	CTRPv2	pan-cancer	AAC	0.3	4e-18
mRNA	TXNDC11	CTRPv2	pan-cancer	AAC	0.3	4e-17
mRNA	PRSS38	CTRPv2	pan-cancer	AAC	0.3	4e-19

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