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OSI-906

OSI-906

Synonyms

Sources	Names Used
CTRPv2	linsitinib
PharmacoGx	OSI-906

External IDs

Database	Identifier
Smiles:	CC1(CC(C1)C2=NC(=C3N2C=CN=C3N)C4=CC5=C(C=C4)C=CC(=N5)C6=CC=CC=C6)O
Inchikey:	PKCDDUHJAFVJJB-UHFFFAOYSA-N
Pubchem:	11640390

FDA Approval Status

Not Approved

Dataset Select

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Top molecular features associated with response to OSI-906

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	ZNF615	CTRPv2	pan-cancer	AAC	0.13	0.0006
mRNA	ZNF649	CTRPv2	pan-cancer	AAC	0.12	0.0008
mRNA	ZNF664	CTRPv2	pan-cancer	AAC	0.14	0.0001
mRNA	ZNF703	CTRPv2	pan-cancer	AAC	0.13	0.001
mRNA	ZNF704	CTRPv2	pan-cancer	AAC	0.18	2e-06
mRNA	ZNF706	CTRPv2	pan-cancer	AAC	0.11	0.003
mRNA	ZNF740	CTRPv2	pan-cancer	AAC	0.32	9e-21
mRNA	ZNF747	CTRPv2	pan-cancer	AAC	0.11	0.003
mRNA	ZNF775	CTRPv2	pan-cancer	AAC	0.14	0.0004
mRNA	ZNF777	CTRPv2	pan-cancer	AAC	0.11	0.003

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