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OSI-906

OSI-906

Synonyms

Sources	Names Used
CTRPv2	linsitinib
PharmacoGx	OSI-906

External IDs

Database	Identifier
Smiles:	CC1(CC(C1)C2=NC(=C3N2C=CN=C3N)C4=CC5=C(C=C4)C=CC(=N5)C6=CC=CC=C6)O
Inchikey:	PKCDDUHJAFVJJB-UHFFFAOYSA-N
Pubchem:	11640390

FDA Approval Status

Not Approved

Dataset Select

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Top molecular features associated with response to OSI-906

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	MBD3L4	CTRPv2	pan-cancer	AAC	0.12	0.003
mRNA	C19orf60	CTRPv2	pan-cancer	AAC	0.11	0.003
mRNA	ITGBL1	CTRPv2	pan-cancer	AAC	-0.11	0.003
mRNA	MCOLN1	CTRPv2	pan-cancer	AAC	0.11	0.003
mRNA	FBXL16	CTRPv2	pan-cancer	AAC	0.11	0.003
mRNA	RNASEH2C	CTRPv2	pan-cancer	AAC	0.11	0.003
mRNA	MRPL24	CTRPv2	pan-cancer	AAC	0.11	0.003
mRNA	FAAH	CTRPv2	pan-cancer	AAC	0.11	0.003
mRNA	TLR6	CTRPv2	pan-cancer	AAC	-0.11	0.003
mRNA	TRPV2	CTRPv2	pan-cancer	AAC	-0.12	0.003

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