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OSI-906

OSI-906

Synonyms

Sources	Names Used
CTRPv2	linsitinib
PharmacoGx	OSI-906

External IDs

Database	Identifier
Smiles:	CC1(CC(C1)C2=NC(=C3N2C=CN=C3N)C4=CC5=C(C=C4)C=CC(=N5)C6=CC=CC=C6)O
Inchikey:	PKCDDUHJAFVJJB-UHFFFAOYSA-N
Pubchem:	11640390

FDA Approval Status

Not Approved

Dataset Select

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Top molecular features associated with response to OSI-906

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	TMC6	CTRPv2	pan-cancer	AAC	0.18	6e-06
mRNA	DUS1L	CTRPv2	pan-cancer	AAC	0.17	6e-06
mRNA	KIF21A	CTRPv2	pan-cancer	AAC	0.2	6e-06
mRNA	EYA1	CTRPv2	pan-cancer	AAC	0.17	6e-06
mRNA	CNBD2	CTRPv2	pan-cancer	AAC	0.16	7e-06
mRNA	HACD1	CTRPv2	pan-cancer	AAC	-0.17	7e-06
mRNA	SPDYE16	CTRPv2	pan-cancer	AAC	0.16	7e-06
mRNA	CADM1	CTRPv2	pan-cancer	AAC	0.16	7e-06
mRNA	HOOK3	CTRPv2	pan-cancer	AAC	0.16	7e-06
mRNA	SLAMF6	CTRPv2	pan-cancer	AAC	-0.17	7e-06

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