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OSI-906

OSI-906

Synonyms

Sources	Names Used
CTRPv2	linsitinib
PharmacoGx	OSI-906

External IDs

Database	Identifier
Smiles:	CC1(CC(C1)C2=NC(=C3N2C=CN=C3N)C4=CC5=C(C=C4)C=CC(=N5)C6=CC=CC=C6)O
Inchikey:	PKCDDUHJAFVJJB-UHFFFAOYSA-N
Pubchem:	11640390

FDA Approval Status

Not Approved

Dataset Select

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Top molecular features associated with response to OSI-906

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	SMG5	CTRPv2	pan-cancer	AAC	0.18	3e-07
mRNA	COMMD3	CTRPv2	pan-cancer	AAC	0.19	3e-07
mRNA	UNC13B	CTRPv2	pan-cancer	AAC	0.18	3e-07
mRNA	CLK2	CTRPv2	pan-cancer	AAC	0.2	4e-07
mRNA	TPM4	CTRPv2	pan-cancer	AAC	-0.2	4e-07
mRNA	SSR4	CTRPv2	pan-cancer	AAC	0.17	4e-07
mRNA	HSD17B8	CTRPv2	pan-cancer	AAC	0.19	4e-07
mRNA	VPS37B	CTRPv2	pan-cancer	AAC	0.18	4e-07
mRNA	ARHGEF12	CTRPv2	pan-cancer	AAC	0.18	4e-07
mRNA	SYNGR2	CTRPv2	pan-cancer	AAC	0.19	4e-07

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