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Compounds
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FTI-277
FTI-277
Synonyms
Sources
Names Used
GDSC1000
FTI-277
PharmacoGx
FTI-277
External IDs
Database
Identifier
Smiles:
COC(=O)C(CCSC)NC(=O)C1=C(C=C(C=C1)NCC(CS)N)C2=CC=CC=C2
Inchikey:
GKFPROVOIQKYTO-UZLBHIALSA-N
Pubchem:
3005532
FDA Approval Status
Not Approved
Plots
Cell Line Summary
Tissue Summary
Molecular Features
Number of cell lines tested with FTI-277
(per dataset)
0
100
200
300
400
500
600
700
800
900
# cell lines
CCLE
gCSI
GRAY
FIMM
CTRPv2
UHNBreast
GDSC1000
0
0
0
0
0
0
941
Download SVG
Number of tissues tested with FTI-277 (per
dataset)
0
5
10
15
20
25
30
35
# tissues
CCLE
gCSI
GRAY
FIMM
CTRPv2
UHNBreast
GDSC1000
0
0
0
0
0
0
35
Download SVG
Dataset Select
all
GDSC1000
FTI-277: AAC
AAC
0.00
0.05
0.10
0.15
0.20
0.25
0.30
0.35
H2369
H2369
KON
KON
MEL-JUSO
MEL-JUSO
FTC-133
FTC-133
SNU-398
SNU-398
MKN28
MKN28
SAT
SAT
MHH-ES-1
MHH-ES-1
HT-3
HT-3
CAL-39
CAL-39
EFM-192A
EFM-192A
RPMI-6666
RPMI-6666
RCC10RGB
RCC10RGB
RERF-LC-Sq1
RERF-LC-Sq1
Saos-2
Saos-2
SU-DHL-10
SU-DHL-10
WM793B
WM793B
ONS-76
ONS-76
SW1088
SW1088
KYSE-30
KYSE-30
EFM-19
EFM-19
TCCSUP
TCCSUP
PA-1
PA-1
G-292;clone A141B1
G-292;clone A141B1
NCI-H1915
NCI-H1915
BICR 22
BICR 22
RPMI-2650
RPMI-2650
SJSA-1
SJSA-1
HCC1806
HCC1806
NCI-H3122
NCI-H3122
G-361
G-361
NCI-H1694
NCI-H1694
KG-1
KG-1
KP-2
KP-2
NOMO-1
NOMO-1
SW948
SW948
TALL-1
TALL-1
JSC-1
JSC-1
HD-MY-Z
HD-MY-Z
Ramos-2G6-4C10
Ramos-2G6-4C10
TE 441.T
TE 441.T
SCC-3
SCC-3
SCC90
SCC90
GA-10
GA-10
NCI-H187
NCI-H187
COLO-668
COLO-668
SBC-5
SBC-5
NCI-H209
NCI-H209
NCI-H1623
NCI-H1623
COR-L95
COR-L95
HuO9
HuO9
NCI-H1581
NCI-H1581
A673
A673
HCC-56
HCC-56
ES1
ES1
HN
HN
T84
T84
K-562
K-562
NCI-H2141
NCI-H2141
SW756
SW756
H2369
KON
MEL-JUSO
FTC-133
SNU-398
MKN28
SAT
MHH-ES-1
HT-3
CAL-39
EFM-192A
RPMI-6666
RCC10RGB
RERF-LC-Sq1
Saos-2
SU-DHL-10
WM793B
ONS-76
SW1088
KYSE-30
EFM-19
TCCSUP
PA-1
G-292;clone A141B1
NCI-H1915
BICR 22
RPMI-2650
SJSA-1
HCC1806
NCI-H3122
G-361
NCI-H1694
KG-1
KP-2
NOMO-1
SW948
TALL-1
JSC-1
HD-MY-Z
Ramos-2G6-4C10
TE 441.T
SCC-3
SCC90
GA-10
NCI-H187
COLO-668
SBC-5
NCI-H209
NCI-H1623
COR-L95
HuO9
NCI-H1581
A673
HCC-56
ES1
HN
T84
K-562
NCI-H2141
SW756
H2369: 0.38
Synonyms: H2369
KON: 0.37
Synonyms: KON
MEL-JUSO: 0.35
Synonyms: MEL-JUSO, MELJUSO
FTC-133: 0.31
Synonyms: FTC-133, FTC133
SNU-398: 0.29
Synonyms: SNU-398, SNU398
MKN28: 0.28
Synonyms: MKN28
SAT: 0.27
Synonyms: SAT
MHH-ES-1: 0.24
Synonyms: MHH-ES-1, MHHES1
HT-3: 0.23
Synonyms: HT-3
CAL-39: 0.23
Synonyms: CAL-39
EFM-192A: 0.23
Synonyms: EFM-192A, EFM192A, efm192a
RPMI-6666: 0.23
Synonyms: RPMI-6666, RPMI6666
RCC10RGB: 0.23
Synonyms: RCC10RGB
RERF-LC-Sq1: 0.22
Synonyms: RERF-LC-Sq1
Saos-2: 0.22
Synonyms: Saos-2, SAOS2
SU-DHL-10: 0.22
Synonyms: SU-DHL-10, SUDHL10
WM793B: 0.22
Synonyms: WM793B
ONS-76: 0.22
Synonyms: ONS-76, ONS76
SW1088: 0.22
Synonyms: SW1088, SW 1088, SW_1088
KYSE-30: 0.21
Synonyms: KYSE-30, KYSE30
EFM-19: 0.21
Synonyms: EFM-19, EFM19, efm19
TCCSUP: 0.20
Synonyms: TCCSUP
PA-1: 0.20
Synonyms: PA-1
G-292;clone A141B1: 0.20
Synonyms: G-292;clone A141B1, G-292, clone A141B1, G-292,_clone_A141B1, G-292-Clone-A141B1, G-292 Clone A141B1, G-292_Clone_A141B1, G292CLONEA141B1
NCI-H1915: 0.19
Synonyms: NCI-H1915, NCIH1915
BICR 22: 0.19
Synonyms: BICR 22, BICR_22, BICR22
RPMI-2650: 0.19
Synonyms: RPMI-2650, RPMI 2650
SJSA-1: 0.18
Synonyms: SJSA-1, SJSA1
HCC1806: 0.18
Synonyms: HCC1806, hcc1806
NCI-H3122: 0.18
Synonyms: NCI-H3122
: 0.00
Synonyms:
: 0.00
Synonyms:
: 0.00
Synonyms:
: 0.00
Synonyms:
: 0.00
Synonyms:
G-361: 0.00
Synonyms: G-361, G361
NCI-H1694: 0.00
Synonyms: NCI-H1694, NCIH1694
KG-1: 0.00
Synonyms: KG-1, KG1
KP-2: 0.00
Synonyms: KP-2, KP2
NOMO-1: 0.00
Synonyms: NOMO-1, NOMO1
SW948: 0.00
Synonyms: SW948, SW 948
TALL-1: 0.00
Synonyms: TALL-1, TALL1
JSC-1: 0.00
Synonyms: JSC-1
HD-MY-Z: 0.00
Synonyms: HD-MY-Z, HDMYZ
Ramos-2G6-4C10: 0.00
Synonyms: Ramos-2G6-4C10
TE 441.T: 0.00
Synonyms: TE 441.T, TE_441.T, TE-441-T, TE441T
SCC-3: 0.00
Synonyms: SCC-3
SCC90: 0.00
Synonyms: SCC90
GA-10: 0.00
Synonyms: GA-10, GA10
NCI-H187: 0.00
Synonyms: NCI-H187
COLO-668: 0.00
Synonyms: COLO-668, COLO 668, COLO_668, COLO668
SBC-5: 0.00
Synonyms: SBC-5, SBC5
NCI-H209: 0.00
Synonyms: NCI-H209, NCIH209
NCI-H1623: 0.00
Synonyms: NCI-H1623, NCIH1623
COR-L95: 0.00
Synonyms: COR-L95, CORL95
HuO9: 0.00
Synonyms: HuO9
NCI-H1581: 0.00
Synonyms: NCI-H1581, NCIH1581
A673: 0.00
Synonyms: A673, A-673
HCC-56: 0.00
Synonyms: HCC-56, HCC56
ES1: 0.00
Synonyms: ES1
HN: 0.00
Synonyms: HN
T84: 0.00
Synonyms: T84
K-562: 0.00
Synonyms: K-562, K562
NCI-H2141: 0.00
Synonyms: NCI-H2141, NCIH2141
SW756: 0.00
Synonyms: SW756
Download SVG
0.00
1.00
2.00
3.00
4.00
5.00
6.00
7.00
8.00
9.00
10.00
11.00
12.00
RT-112
RT-112
PA-1
PA-1
HT-1197
HT-1197
SK-MM-2
SK-MM-2
LB1047-RCC
LB1047-RCC
KP-N-YN
KP-N-YN
Calu-3
Calu-3
TK10
TK10
GI-ME-N
GI-ME-N
U251
U251
HGC-27
HGC-27
BICR 22
BICR 22
NCI-H1299
NCI-H1299
GAK
GAK
KNS-81-FD
KNS-81-FD
D-336MG
D-336MG
SW962
SW962
LB2241-RCC
LB2241-RCC
T98G
T98G
NCI-H441
NCI-H441
PL18
PL18
RF-48
RF-48
697
697
OUMS-23
OUMS-23
D-542MG
D-542MG
JHU-011
JHU-011
LoVo
LoVo
PFSK-1
PFSK-1
RPMI-8402
RPMI-8402
T.T
T.T
SK-N-SH
SK-N-SH
KYSE-70
KYSE-70
WM35
WM35
NCI-H2030
NCI-H2030
NCI-H1355
NCI-H1355
ES6
ES6
IGR-1
IGR-1
COR-L23
COR-L23
TE-15
TE-15
HuCCT1
HuCCT1
HT-115
HT-115
KS-1
KS-1
Daoy
Daoy
COLO-741
COLO-741
JIMT-1
JIMT-1
CGTH-W-1
CGTH-W-1
SN12C
SN12C
SW982
SW982
HMV-II
HMV-II
JHH-7
JHH-7
K19
K19
NCI-H3122
NCI-H3122
IA-LM
IA-LM
IHH-4
IHH-4
ONS-76
ONS-76
A704
A704
A498
A498
SNU-398
SNU-398
KON
KON
MEL-JUSO
MEL-JUSO
RT-112
PA-1
HT-1197
SK-MM-2
LB1047-RCC
KP-N-YN
Calu-3
TK10
GI-ME-N
U251
HGC-27
BICR 22
NCI-H1299
GAK
KNS-81-FD
D-336MG
SW962
LB2241-RCC
T98G
NCI-H441
PL18
RF-48
697
OUMS-23
D-542MG
JHU-011
LoVo
PFSK-1
RPMI-8402
T.T
SK-N-SH
KYSE-70
WM35
NCI-H2030
NCI-H1355
ES6
IGR-1
COR-L23
TE-15
HuCCT1
HT-115
KS-1
Daoy
COLO-741
JIMT-1
CGTH-W-1
SN12C
SW982
HMV-II
JHH-7
K19
NCI-H3122
IA-LM
IHH-4
ONS-76
A704
A498
SNU-398
KON
MEL-JUSO
RT-112: 11.90 (log10 µM)
Synonyms: RT-112, RT112
PA-1: 9.91 (log10 µM)
Synonyms: PA-1
HT-1197: 7.98 (log10 µM)
Synonyms: HT-1197, HT1197
SK-MM-2: 7.59 (log10 µM)
Synonyms: SK-MM-2, SKMM2
LB1047-RCC: 7.36 (log10 µM)
Synonyms: LB1047-RCC
KP-N-YN: 7.30 (log10 µM)
Synonyms: KP-N-YN, KPNYN
Calu-3: 7.28 (log10 µM)
Synonyms: Calu-3, CALU3
TK10: 7.21 (log10 µM)
Synonyms: TK10, TK-10
GI-ME-N: 7.12 (log10 µM)
Synonyms: GI-ME-N
U251: 6.91 (log10 µM)
Synonyms: U251, U-251 MG, U-251_MG
HGC-27: 6.48 (log10 µM)
Synonyms: HGC-27, HGC27
BICR 22: 6.18 (log10 µM)
Synonyms: BICR 22, BICR_22, BICR22
NCI-H1299: 6.00 (log10 µM)
Synonyms: NCI-H1299, NCIH1299
GAK: 5.76 (log10 µM)
Synonyms: GAK
KNS-81-FD: 5.53 (log10 µM)
Synonyms: KNS-81-FD, KNS-81
D-336MG: 5.51 (log10 µM)
Synonyms: D-336MG
SW962: 5.35 (log10 µM)
Synonyms: SW962
LB2241-RCC: 5.30 (log10 µM)
Synonyms: LB2241-RCC
T98G: 5.26 (log10 µM)
Synonyms: T98G
NCI-H441: 5.24 (log10 µM)
Synonyms: NCI-H441, NCIH441
PL18: 5.16 (log10 µM)
Synonyms: PL18
RF-48: 5.04 (log10 µM)
Synonyms: RF-48
697: 5.00 (log10 µM)
Synonyms: 697
OUMS-23: 4.92 (log10 µM)
Synonyms: OUMS-23, OUMS23
D-542MG: 4.87 (log10 µM)
Synonyms: D-542MG
JHU-011: 4.75 (log10 µM)
Synonyms: JHU-011
LoVo: 4.74 (log10 µM)
Synonyms: LoVo, LOVO
PFSK-1: 4.67 (log10 µM)
Synonyms: PFSK-1
RPMI-8402: 4.51 (log10 µM)
Synonyms: RPMI-8402, RPMI8402
T.T: 4.51 (log10 µM)
Synonyms: T.T, T-T
: 0.00 (log10 µM)
Synonyms:
: 0.00 (log10 µM)
Synonyms:
: 0.00 (log10 µM)
Synonyms:
: 0.00 (log10 µM)
Synonyms:
: 0.00 (log10 µM)
Synonyms:
SK-N-SH: 0.17 (log10 µM)
Synonyms: SK-N-SH, SKNSH
KYSE-70: 0.17 (log10 µM)
Synonyms: KYSE-70, KYSE70
WM35: 0.17 (log10 µM)
Synonyms: WM35
NCI-H2030: 0.17 (log10 µM)
Synonyms: NCI-H2030, NCIH2030
NCI-H1355: 0.17 (log10 µM)
Synonyms: NCI-H1355, NCIH1355
ES6: 0.16 (log10 µM)
Synonyms: ES6
IGR-1: 0.15 (log10 µM)
Synonyms: IGR-1, IGR1
COR-L23: 0.15 (log10 µM)
Synonyms: COR-L23
TE-15: 0.15 (log10 µM)
Synonyms: TE-15, TE15
HuCCT1: 0.15 (log10 µM)
Synonyms: HuCCT1, HUCCT1
HT-115: 0.15 (log10 µM)
Synonyms: HT-115, HT115
KS-1: 0.15 (log10 µM)
Synonyms: KS-1
Daoy: 0.14 (log10 µM)
Synonyms: Daoy, DAOY
COLO-741: 0.11 (log10 µM)
Synonyms: COLO-741, COLO 741, COLO_741, COLO741
JIMT-1: 0.10 (log10 µM)
Synonyms: JIMT-1, JIMT1, jimt1
CGTH-W-1: 0.09 (log10 µM)
Synonyms: CGTH-W-1, CGTHW1
SN12C: 0.09 (log10 µM)
Synonyms: SN12C
SW982: 0.07 (log10 µM)
Synonyms: SW982, SW 982
HMV-II: 0.05 (log10 µM)
Synonyms: HMV-II, HMVII
JHH-7: 0.01 (log10 µM)
Synonyms: JHH-7
K19: -0.02 (log10 µM)
Synonyms: K19
NCI-H3122: -0.02 (log10 µM)
Synonyms: NCI-H3122
IA-LM: -0.03 (log10 µM)
Synonyms: IA-LM, IALM
IHH-4: -0.06 (log10 µM)
Synonyms: IHH-4
ONS-76: -0.11 (log10 µM)
Synonyms: ONS-76, ONS76
A704: -0.15 (log10 µM)
Synonyms: A704, A-704
A498: -0.19 (log10 µM)
Synonyms: A498, A-498
SNU-398: -0.40 (log10 µM)
Synonyms: SNU-398, SNU398
KON: -0.67 (log10 µM)
Synonyms: KON
MEL-JUSO: -0.82 (log10 µM)
Synonyms: MEL-JUSO, MELJUSO
AAC
pIC50
* Plot represents the top and bottom 30 data points
** Error Bars represent the Median Absolute Deviation
Download SVG
Download Data as CSV
FTI-277: AAC
AAC
Tissues
0.00
0.05
0.10
0.15
0.20
0.25
0.30
0.35
gastrointestinal_tract_(site_indeterminate)
gastrointestinal_tract_(site_indeterminate)
haematopoietic_and_lymphoid_tissue
haematopoietic_and_lymphoid_tissue
prostate
prostate
autonomic_ganglia
autonomic_ganglia
lung
lung
soft_tissue
soft_tissue
bone
bone
large_intestine
large_intestine
neuroblastoma
neuroblastoma
endometrium
endometrium
cervix
cervix
small_intestine
small_intestine
central_nervous_system
central_nervous_system
biliary_tract
biliary_tract
stomach
stomach
oesophagus
oesophagus
pancreas
pancreas
liver
liver
skin
skin
breast
breast
testis
testis
pleura
pleura
misc
misc
ovary
ovary
kidney
kidney
urinary_tract
urinary_tract
upper_aerodigestive_tract
upper_aerodigestive_tract
thyroid
thyroid
head_and_neck
head_and_neck
placenta
placenta
salivary_gland
salivary_gland
vulva
vulva
other
other
adrenal_gland
adrenal_gland
oral_cavity
oral_cavity
0.00
1.00
2.00
3.00
4.00
5.00
6.00
7.00
8.00
misc
misc
placenta
placenta
salivary_gland
salivary_gland
oral_cavity
oral_cavity
gastrointestinal_tract_(site_indeterminate)
gastrointestinal_tract_(site_indeterminate)
adrenal_gland
adrenal_gland
neuroblastoma
neuroblastoma
biliary_tract
biliary_tract
pleura
pleura
other
other
breast
breast
skin
skin
pancreas
pancreas
lung
lung
prostate
prostate
large_intestine
large_intestine
soft_tissue
soft_tissue
oesophagus
oesophagus
liver
liver
bone
bone
thyroid
thyroid
upper_aerodigestive_tract
upper_aerodigestive_tract
central_nervous_system
central_nervous_system
urinary_tract
urinary_tract
haematopoietic_and_lymphoid_tissue
haematopoietic_and_lymphoid_tissue
autonomic_ganglia
autonomic_ganglia
endometrium
endometrium
kidney
kidney
cervix
cervix
stomach
stomach
ovary
ovary
testis
testis
small_intestine
small_intestine
head_and_neck
head_and_neck
vulva
vulva
AAC
pIC50
= Truncated outliers
Download SVG
Top molecular features associated with response to FTI-277
Feature Type
Gene
Dataset
Tissue
Stat
Standardized
Coefficient
Nominal ANOVA
p-value
mRNA
IGFBPL1
GDSC1000
pan-cancer
AAC
-0.097
0.01
mRNA
LY6H
GDSC1000
pan-cancer
AAC
-0.081
0.01
mRNA
SKP2
GDSC1000
pan-cancer
AAC
-0.085
0.01
mRNA
MCM3
GDSC1000
pan-cancer
AAC
-0.091
0.01
mRNA
C2CD2
GDSC1000
pan-cancer
AAC
0.085
0.01
mRNA
CARD10
GDSC1000
pan-cancer
AAC
0.1
0.01
mRNA
UBXN6
GDSC1000
pan-cancer
AAC
0.084
0.01
mRNA
DDI1
GDSC1000
pan-cancer
AAC
0.083
0.01
mRNA
SP100
GDSC1000
pan-cancer
AAC
0.093
0.01
mRNA
LAMB3
GDSC1000
pan-cancer
AAC
0.1
0.01
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