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CHIR-99021

Synonyms

SourcesNames Used
GDSC1000, CTRPv2CHIR-99021
PharmacoGx CHIR-99021

External IDs

DatabaseIdentifier
Smiles: CC1=CN=C(N1)C2=CN=C(N=C2C3=C(C=C(C=C3)Cl)Cl)NCCNC4=NC=C(C=C4)C#N
Inchikey: AQGNHMOJWBZFQQ-UHFFFAOYSA-N
Pubchem: 9956119

Annotated Targets

CDK1, GSK3A, GSK3B, MAPK1

FDA Approval Status

Not Approved
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Top molecular features associated with response to CHIR-99021


Feature TypeStandardized
Nominal ANOVA
mRNA PDIK1L GDSC1000 pan-cancer AAC -0.2 4e-08
mRNA RAG1 CTRPv2 pan-cancer AAC 0.18 4e-08
mRNA DCBLD2 GDSC1000 pan-cancer AAC 0.22 4e-08
mRNA SMURF2 GDSC1000 pan-cancer AAC 0.18 5e-08
mRNA PPIC GDSC1000 pan-cancer AAC 0.24 5e-08
mRNA FKBP10 GDSC1000 pan-cancer AAC 0.21 5e-08
mRNA GCH1 GDSC1000 pan-cancer AAC -0.19 5e-08
mRNA CUL7 GDSC1000 pan-cancer AAC 0.17 6e-08
mRNA MFSD9 GDSC1000 pan-cancer AAC -0.18 6e-08
mRNA COL4A1 GDSC1000 pan-cancer AAC 0.22 6e-08
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