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AZD-2281

AZD-2281

Synonyms

Sources	Names Used
GDSC1000, FIMM	Olaparib
CTRPv2	olaparib
PharmacoGx	AZD-2281

External IDs

Database	Identifier
Smiles:	C1CC1C(=O)N2CCN(CC2)C(=O)C3=C(C=CC(=C3)CC4=NNC(=O)C5=CC=CC=C54)F
Inchikey:	FDLYAMZZIXQODN-UHFFFAOYSA-N
Pubchem:	23725625

FDA Approval Status

Approved

Dataset Select

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Top molecular features associated with response to AZD-2281

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	ZNF124	CTRPv2	pan-cancer	AAC	0.2	3e-07
mRNA	ALPPL2	CTRPv2	pan-cancer	AAC	0.17	3e-07
mRNA	CASP2	CTRPv2	pan-cancer	AAC	0.19	3e-07
mRNA	GAD1	CTRPv2	pan-cancer	AAC	0.17	3e-07
mRNA	IKZF2	CTRPv2	pan-cancer	AAC	0.19	3e-07
mRNA	ZCCHC18	CTRPv2	pan-cancer	AAC	0.19	3e-07
mRNA	MEGF11	CTRPv2	pan-cancer	AAC	0.17	3e-07
mRNA	ZMYM4	CTRPv2	pan-cancer	AAC	0.18	4e-07
mRNA	LMAN2	CTRPv2	pan-cancer	AAC	-0.18	4e-07
mRNA	KDM6B	CTRPv2	pan-cancer	AAC	0.18	4e-07

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