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AZD-2281

AZD-2281

Synonyms

Sources	Names Used
GDSC1000, FIMM	Olaparib
CTRPv2	olaparib
PharmacoGx	AZD-2281

External IDs

Database	Identifier
Smiles:	C1CC1C(=O)N2CCN(CC2)C(=O)C3=C(C=CC(=C3)CC4=NNC(=O)C5=CC=CC=C54)F
Inchikey:	FDLYAMZZIXQODN-UHFFFAOYSA-N
Pubchem:	23725625

FDA Approval Status

Approved

Dataset Select

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Top molecular features associated with response to AZD-2281

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	ZNF627	CTRPv2	pan-cancer	AAC	0.14	0.0001
mRNA	ZNF644	CTRPv2	pan-cancer	AAC	0.11	0.001
mRNA	ZNF646	CTRPv2	pan-cancer	AAC	0.14	0.0001
mRNA	ZNF66	CTRPv2	pan-cancer	AAC	0.15	3e-05
mRNA	ZNF669	CTRPv2	pan-cancer	AAC	0.22	2e-09
mRNA	ZNF675	CTRPv2	pan-cancer	AAC	0.12	0.001
mRNA	ZNF678	CTRPv2	pan-cancer	AAC	0.21	6e-09
mRNA	ZNF682	CTRPv2	pan-cancer	AAC	0.14	0.0001
mRNA	ZNF691	CTRPv2	pan-cancer	AAC	0.12	0.001
mRNA	ZNF695	CTRPv2	pan-cancer	AAC	0.12	0.001

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