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AZD-2281

AZD-2281

Synonyms

Sources	Names Used
GDSC1000, FIMM	Olaparib
CTRPv2	olaparib
PharmacoGx	AZD-2281

External IDs

Database	Identifier
Smiles:	C1CC1C(=O)N2CCN(CC2)C(=O)C3=C(C=CC(=C3)CC4=NNC(=O)C5=CC=CC=C54)F
Inchikey:	FDLYAMZZIXQODN-UHFFFAOYSA-N
Pubchem:	23725625

FDA Approval Status

Approved

Dataset Select

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Top molecular features associated with response to AZD-2281

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	UNC13A	CTRPv2	pan-cancer	AAC	0.11	0.002
mRNA	ZNF77	CTRPv2	pan-cancer	AAC	0.11	0.002
mRNA	ZDHHC15	CTRPv2	pan-cancer	AAC	0.11	0.002
mRNA	HCN3	CTRPv2	pan-cancer	AAC	0.11	0.002
mRNA	CLCN6	CTRPv2	pan-cancer	AAC	0.11	0.002
mRNA	MT-CO2	CTRPv2	pan-cancer	AAC	-0.12	0.002
mRNA	SNCA	FIMM	pan-cancer	AAC	0.57	0.002
mRNA	ASAH1	CTRPv2	pan-cancer	AAC	-0.12	0.002
mRNA	MUL1	CTRPv2	pan-cancer	AAC	-0.12	0.002
mRNA	PDCD6IP	FIMM	pan-cancer	AAC	-0.49	0.002

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