PharmacoDB

Sources

Names Used

Navitoclax

navitoclax

PharmacoGx

ABT-263

Database	Identifier
Smiles:	CC1(CCC(=C(C1)CN2CCN(CC2)C3=CC=C(C=C3)C(=O)NS(=O)(=O)C4=CC(=C(C=C4)NC(CCN5CCOCC5)CSC6=CC=CC=C6)S(=O)(=O)C(F)(F)F)C7=CC=C(C=C7)Cl)C
Inchikey:	JLYAXFNOILIKPP-KXQOOQHDSA-N
Pubchem:	24978538

Database

Identifier

Smiles:

CC1(CCC(=C(C1)CN2CCN(CC2)C3=CC=C(C=C3)C(=O)NS(=O)(=O)C4=CC(=C(C=C4)NC(CCN5CCOCC5)CSC6=CC=CC=C6)S(=O)(=O)C(F)(F)F)C7=CC=C(C=C7)Cl)C

Inchikey:

JLYAXFNOILIKPP-KXQOOQHDSA-N

Pubchem:

Top molecular features associated with response to ABT-263

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	MRPS21	CTRPv2	pan-cancer	AAC	-0.21	1e-08
mRNA	DAP3	CTRPv2	pan-cancer	AAC	-0.21	9e-09
mRNA	MRPL9	CTRPv2	pan-cancer	AAC	-0.21	8e-09
mRNA	RAB13	CTRPv2	pan-cancer	AAC	-0.21	6e-07
mRNA	MTX1	CTRPv2	pan-cancer	AAC	-0.21	5e-09
mRNA	GPATCH4	CTRPv2	pan-cancer	AAC	-0.21	4e-09
mRNA	THEM4	CTRPv2	pan-cancer	AAC	-0.23	6e-09
mRNA	MRPL24	CTRPv2	pan-cancer	AAC	-0.24	3e-11
mRNA	STYXL1	FIMM	pan-cancer	AAC	-0.49	0.0004
mRNA	ADGRL2	FIMM	pan-cancer	AAC	-0.55	0.0002