PharmacoDB

Sources

Names Used

Navitoclax

navitoclax

PharmacoGx

ABT-263

Database	Identifier
Smiles:	CC1(CCC(=C(C1)CN2CCN(CC2)C3=CC=C(C=C3)C(=O)NS(=O)(=O)C4=CC(=C(C=C4)NC(CCN5CCOCC5)CSC6=CC=CC=C6)S(=O)(=O)C(F)(F)F)C7=CC=C(C=C7)Cl)C
Inchikey:	JLYAXFNOILIKPP-KXQOOQHDSA-N
Pubchem:	24978538

Database

Identifier

Smiles:

CC1(CCC(=C(C1)CN2CCN(CC2)C3=CC=C(C=C3)C(=O)NS(=O)(=O)C4=CC(=C(C=C4)NC(CCN5CCOCC5)CSC6=CC=CC=C6)S(=O)(=O)C(F)(F)F)C7=CC=C(C=C7)Cl)C

Inchikey:

JLYAXFNOILIKPP-KXQOOQHDSA-N

Pubchem:

Top molecular features associated with response to ABT-263

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	AC090154.1	CTRPv2	pan-cancer	AAC	0.16	3e-05
mRNA	AC087350.1	CTRPv2	pan-cancer	AAC	0.16	2e-05
mRNA	AC084219.2	CTRPv2	pan-cancer	AAC	0.15	5e-05
mRNA	AC069499.1	CTRPv2	pan-cancer	AAC	0.13	0.0003
mRNA	AC024361.1	CTRPv2	pan-cancer	AAC	0.19	2e-07
mRNA	AC015688.3	CTRPv2	pan-cancer	AAC	0.21	8e-08
mRNA	AC005281.1	CTRPv2	pan-cancer	AAC	0.14	0.0002
mRNA	AC004076.9	CTRPv2	pan-cancer	AAC	0.16	1e-05
mRNA	AC003006.7	CTRPv2	pan-cancer	AAC	0.25	3e-12
mRNA	AC003005.4	CTRPv2	pan-cancer	AAC	0.16	4e-06