PharmacoDB

Sources

Names Used

Navitoclax

navitoclax

PharmacoGx

ABT-263

Database	Identifier
Smiles:	CC1(CCC(=C(C1)CN2CCN(CC2)C3=CC=C(C=C3)C(=O)NS(=O)(=O)C4=CC(=C(C=C4)NC(CCN5CCOCC5)CSC6=CC=CC=C6)S(=O)(=O)C(F)(F)F)C7=CC=C(C=C7)Cl)C
Inchikey:	JLYAXFNOILIKPP-KXQOOQHDSA-N
Pubchem:	24978538

Database

Identifier

Smiles:

CC1(CCC(=C(C1)CN2CCN(CC2)C3=CC=C(C=C3)C(=O)NS(=O)(=O)C4=CC(=C(C=C4)NC(CCN5CCOCC5)CSC6=CC=CC=C6)S(=O)(=O)C(F)(F)F)C7=CC=C(C=C7)Cl)C

Inchikey:

JLYAXFNOILIKPP-KXQOOQHDSA-N

Pubchem:

Top molecular features associated with response to ABT-263

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	PSMD4	CTRPv2	pan-cancer	AAC	-0.18	3e-07
mRNA	EMC6	CTRPv2	pan-cancer	AAC	-0.18	4e-07
mRNA	CCT3	CTRPv2	pan-cancer	AAC	-0.18	3e-07
mRNA	HDLBP	CTRPv2	pan-cancer	AAC	-0.18	2e-06
mRNA	SHC1	CTRPv2	pan-cancer	AAC	-0.19	7e-07
mRNA	PFDN2	CTRPv2	pan-cancer	AAC	-0.19	7e-08
mRNA	MCL1	CTRPv2	pan-cancer	AAC	-0.19	2e-08
mRNA	DUS2	CTRPv2	pan-cancer	AAC	-0.19	3e-08
mRNA	HAX1	CTRPv2	pan-cancer	AAC	-0.2	9e-08
mRNA	NBPF15	CTRPv2	pan-cancer	AAC	-0.2	3e-08