PharmacoDB

Sources

Names Used

Navitoclax

navitoclax

PharmacoGx

ABT-263

Database	Identifier
Smiles:	CC1(CCC(=C(C1)CN2CCN(CC2)C3=CC=C(C=C3)C(=O)NS(=O)(=O)C4=CC(=C(C=C4)NC(CCN5CCOCC5)CSC6=CC=CC=C6)S(=O)(=O)C(F)(F)F)C7=CC=C(C=C7)Cl)C
Inchikey:	JLYAXFNOILIKPP-KXQOOQHDSA-N
Pubchem:	24978538

Database

Identifier

Smiles:

CC1(CCC(=C(C1)CN2CCN(CC2)C3=CC=C(C=C3)C(=O)NS(=O)(=O)C4=CC(=C(C=C4)NC(CCN5CCOCC5)CSC6=CC=CC=C6)S(=O)(=O)C(F)(F)F)C7=CC=C(C=C7)Cl)C

Inchikey:

JLYAXFNOILIKPP-KXQOOQHDSA-N

Pubchem:

Top molecular features associated with response to ABT-263

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	C2orf47	CTRPv2	pan-cancer	AAC	-0.18	1e-06
mRNA	NDUFS2	CTRPv2	pan-cancer	AAC	-0.18	6e-07
mRNA	EIF5A	CTRPv2	pan-cancer	AAC	-0.18	5e-07
mRNA	RP3-461F17.3	CTRPv2	pan-cancer	AAC	-0.17	6e-07
mRNA	NOB1	CTRPv2	pan-cancer	AAC	-0.17	5e-06
mRNA	ATP5D	CTRPv2	pan-cancer	AAC	-0.17	2e-06
mRNA	UBE2J1	CTRPv2	pan-cancer	AAC	-0.17	2e-05
mRNA	TNFRSF10A	CTRPv2	pan-cancer	AAC	-0.17	8e-06
mRNA	DCAF6	CTRPv2	pan-cancer	AAC	-0.17	1e-05
mRNA	MRPL41	CTRPv2	pan-cancer	AAC	-0.17	4e-06