PharmacoDB

Sources

Names Used

Navitoclax

navitoclax

PharmacoGx

ABT-263

Database	Identifier
Smiles:	CC1(CCC(=C(C1)CN2CCN(CC2)C3=CC=C(C=C3)C(=O)NS(=O)(=O)C4=CC(=C(C=C4)NC(CCN5CCOCC5)CSC6=CC=CC=C6)S(=O)(=O)C(F)(F)F)C7=CC=C(C=C7)Cl)C
Inchikey:	JLYAXFNOILIKPP-KXQOOQHDSA-N
Pubchem:	24978538

Database

Identifier

Smiles:

CC1(CCC(=C(C1)CN2CCN(CC2)C3=CC=C(C=C3)C(=O)NS(=O)(=O)C4=CC(=C(C=C4)NC(CCN5CCOCC5)CSC6=CC=CC=C6)S(=O)(=O)C(F)(F)F)C7=CC=C(C=C7)Cl)C

Inchikey:

JLYAXFNOILIKPP-KXQOOQHDSA-N

Pubchem:

Top molecular features associated with response to ABT-263

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	EMILIN2	FIMM	pan-cancer	AAC	0.54	0.0005
mRNA	NEUROG1	FIMM	pan-cancer	AAC	0.54	0.0002
mRNA	MTHFR	FIMM	pan-cancer	AAC	0.55	0.0001
mRNA	COL9A1	FIMM	pan-cancer	AAC	0.57	0.0002
mRNA	TSKS	FIMM	pan-cancer	AAC	0.57	0.0008
mRNA	A1CF	FIMM	pan-cancer	AAC	0.57	0.0005
mRNA	RAB11B	FIMM	pan-cancer	AAC	0.57	3e-05
mRNA	PHF7	FIMM	pan-cancer	AAC	0.58	0.0008
mRNA	CEACAM4	FIMM	pan-cancer	AAC	0.58	0.0002
mRNA	HIST1H2BB	FIMM	pan-cancer	AAC	0.59	3e-05