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ABT-263

Synonyms

SourcesNames Used
GDSC1000, FIMMNavitoclax
CTRPv2navitoclax
PharmacoGx ABT-263

External IDs

DatabaseIdentifier
Smiles: CC1(CCC(=C(C1)CN2CCN(CC2)C3=CC=C(C=C3)C(=O)NS(=O)(=O)C4=CC(=C(C=C4)NC(CCN5CCOCC5)CSC6=CC=CC=C6)S(=O)(=O)C(F)(F)F)C7=CC=C(C=C7)Cl)C
Inchikey: JLYAXFNOILIKPP-KXQOOQHDSA-N
Pubchem: 24978538

Annotated Targets

BCL2, BCL2L2, BAD

FDA Approval Status

Not Approved
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Top molecular features associated with response to ABT-263


Feature TypeStandardized
Nominal ANOVA
mRNA RP11-468E2.2 CTRPv2 pan-cancer AAC -0.12 0.0008
mRNA ZNF358 CTRPv2 pan-cancer AAC 0.13 0.0008
mRNA DYNLL1 CTRPv2 pan-cancer AAC -0.12 0.0008
mRNA SPECC1L CTRPv2 pan-cancer AAC 0.12 0.0008
mRNA TSKS FIMM pan-cancer AAC 0.57 0.0008
mRNA DBP CTRPv2 pan-cancer AAC 0.12 0.0008
mRNA LEMD3 CTRPv2 pan-cancer AAC 0.12 0.0008
mRNA GPR155 CTRPv2 pan-cancer AAC 0.12 0.0008
mRNA MAP1LC3B2 CTRPv2 pan-cancer AAC -0.12 0.0008
mRNA RPE CTRPv2 pan-cancer AAC -0.12 0.0008
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