PharmacoDB

Sources

Names Used

Navitoclax

navitoclax

PharmacoGx

ABT-263

Database	Identifier
Smiles:	CC1(CCC(=C(C1)CN2CCN(CC2)C3=CC=C(C=C3)C(=O)NS(=O)(=O)C4=CC(=C(C=C4)NC(CCN5CCOCC5)CSC6=CC=CC=C6)S(=O)(=O)C(F)(F)F)C7=CC=C(C=C7)Cl)C
Inchikey:	JLYAXFNOILIKPP-KXQOOQHDSA-N
Pubchem:	24978538

Database

Identifier

Smiles:

CC1(CCC(=C(C1)CN2CCN(CC2)C3=CC=C(C=C3)C(=O)NS(=O)(=O)C4=CC(=C(C=C4)NC(CCN5CCOCC5)CSC6=CC=CC=C6)S(=O)(=O)C(F)(F)F)C7=CC=C(C=C7)Cl)C

Inchikey:

JLYAXFNOILIKPP-KXQOOQHDSA-N

Pubchem:

Top molecular features associated with response to ABT-263

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	ZNF862	CTRPv2	pan-cancer	AAC	0.13	0.0002
mRNA	ZNF865	CTRPv2	pan-cancer	AAC	0.13	0.0005
mRNA	ZNF878	CTRPv2	pan-cancer	AAC	0.16	2e-05
mRNA	ZNF891	CTRPv2	pan-cancer	AAC	0.17	5e-06
mRNA	ZNF91	CTRPv2	pan-cancer	AAC	0.17	2e-06
mRNA	ZNF92	CTRPv2	pan-cancer	AAC	0.14	0.0001
mRNA	ZNF93	CTRPv2	pan-cancer	AAC	0.18	2e-06
mRNA	ZNRF1	CTRPv2	pan-cancer	AAC	0.13	0.0003
mRNA	ZPBP	FIMM	pan-cancer	AAC	0.45	0.0006
mRNA	ZRANB1	CTRPv2	pan-cancer	AAC	0.12	0.0006