PharmacoDB

Sources

Names Used

Navitoclax

navitoclax

PharmacoGx

ABT-263

Database	Identifier
Smiles:	CC1(CCC(=C(C1)CN2CCN(CC2)C3=CC=C(C=C3)C(=O)NS(=O)(=O)C4=CC(=C(C=C4)NC(CCN5CCOCC5)CSC6=CC=CC=C6)S(=O)(=O)C(F)(F)F)C7=CC=C(C=C7)Cl)C
Inchikey:	JLYAXFNOILIKPP-KXQOOQHDSA-N
Pubchem:	24978538

Database

Identifier

Smiles:

CC1(CCC(=C(C1)CN2CCN(CC2)C3=CC=C(C=C3)C(=O)NS(=O)(=O)C4=CC(=C(C=C4)NC(CCN5CCOCC5)CSC6=CC=CC=C6)S(=O)(=O)C(F)(F)F)C7=CC=C(C=C7)Cl)C

Inchikey:

JLYAXFNOILIKPP-KXQOOQHDSA-N

Pubchem:

Top molecular features associated with response to ABT-263

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	ZNF783	CTRPv2	pan-cancer	AAC	0.14	0.0001
mRNA	ZNF784	CTRPv2	pan-cancer	AAC	0.2	8e-09
mRNA	ZNF785	CTRPv2	pan-cancer	AAC	0.21	1e-08
mRNA	ZNF786	CTRPv2	pan-cancer	AAC	0.13	0.0006
mRNA	ZNF790	CTRPv2	pan-cancer	AAC	0.19	2e-07
mRNA	ZNF8	CTRPv2	pan-cancer	AAC	0.29	6e-14
mRNA	ZNF808	CTRPv2	pan-cancer	AAC	0.21	1e-08
mRNA	ZNF81	CTRPv2	pan-cancer	AAC	0.16	7e-06
mRNA	ZNF814	CTRPv2	pan-cancer	AAC	0.21	2e-08
mRNA	ZNF821	CTRPv2	pan-cancer	AAC	0.16	3e-05