PharmacoDB

Sources

Names Used

Navitoclax

navitoclax

PharmacoGx

ABT-263

Database	Identifier
Smiles:	CC1(CCC(=C(C1)CN2CCN(CC2)C3=CC=C(C=C3)C(=O)NS(=O)(=O)C4=CC(=C(C=C4)NC(CCN5CCOCC5)CSC6=CC=CC=C6)S(=O)(=O)C(F)(F)F)C7=CC=C(C=C7)Cl)C
Inchikey:	JLYAXFNOILIKPP-KXQOOQHDSA-N
Pubchem:	24978538

Database

Identifier

Smiles:

CC1(CCC(=C(C1)CN2CCN(CC2)C3=CC=C(C=C3)C(=O)NS(=O)(=O)C4=CC(=C(C=C4)NC(CCN5CCOCC5)CSC6=CC=CC=C6)S(=O)(=O)C(F)(F)F)C7=CC=C(C=C7)Cl)C

Inchikey:

JLYAXFNOILIKPP-KXQOOQHDSA-N

Pubchem:

Top molecular features associated with response to ABT-263

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	RP11-729L2.2	CTRPv2	pan-cancer	AAC	0.27	6e-13
mRNA	WDR7	CTRPv2	pan-cancer	AAC	0.28	1e-12
mRNA	ZNF84	CTRPv2	pan-cancer	AAC	0.25	2e-12
mRNA	SMAD4	CTRPv2	pan-cancer	AAC	0.26	2e-12
mRNA	KIAA1147	CTRPv2	pan-cancer	AAC	0.25	2e-12
mRNA	AC003006.7	CTRPv2	pan-cancer	AAC	0.25	3e-12
mRNA	SLC35E2	CTRPv2	pan-cancer	AAC	0.26	4e-12
mRNA	ZNF766	CTRPv2	pan-cancer	AAC	0.26	4e-12
mRNA	BEND5	CTRPv2	pan-cancer	AAC	0.25	4e-12
mRNA	SMIM17	CTRPv2	pan-cancer	AAC	0.25	5e-12