PharmacoDB

Sources

Names Used

Navitoclax

navitoclax

PharmacoGx

ABT-263

Database	Identifier
Smiles:	CC1(CCC(=C(C1)CN2CCN(CC2)C3=CC=C(C=C3)C(=O)NS(=O)(=O)C4=CC(=C(C=C4)NC(CCN5CCOCC5)CSC6=CC=CC=C6)S(=O)(=O)C(F)(F)F)C7=CC=C(C=C7)Cl)C
Inchikey:	JLYAXFNOILIKPP-KXQOOQHDSA-N
Pubchem:	24978538

Database

Identifier

Smiles:

CC1(CCC(=C(C1)CN2CCN(CC2)C3=CC=C(C=C3)C(=O)NS(=O)(=O)C4=CC(=C(C=C4)NC(CCN5CCOCC5)CSC6=CC=CC=C6)S(=O)(=O)C(F)(F)F)C7=CC=C(C=C7)Cl)C

Inchikey:

JLYAXFNOILIKPP-KXQOOQHDSA-N

Pubchem:

Top molecular features associated with response to ABT-263

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	HECTD4	CTRPv2	pan-cancer	AAC	0.23	3e-10
mRNA	LDOC1L	CTRPv2	pan-cancer	AAC	0.24	3e-10
mRNA	ZSCAN2	CTRPv2	pan-cancer	AAC	0.24	4e-10
mRNA	CBFA2T2	CTRPv2	pan-cancer	AAC	0.22	4e-10
mRNA	ZNF100	CTRPv2	pan-cancer	AAC	0.24	4e-10
mRNA	CIC	CTRPv2	pan-cancer	AAC	0.22	5e-10
mRNA	KLHL23	CTRPv2	pan-cancer	AAC	0.24	5e-10
mRNA	ZNF548	CTRPv2	pan-cancer	AAC	0.23	5e-10
mRNA	ZNF250	CTRPv2	pan-cancer	AAC	0.23	5e-10
mRNA	BSN	CTRPv2	pan-cancer	AAC	0.24	5e-10