PharmacoDB

Sources

Names Used

Navitoclax

navitoclax

PharmacoGx

ABT-263

Database	Identifier
Smiles:	CC1(CCC(=C(C1)CN2CCN(CC2)C3=CC=C(C=C3)C(=O)NS(=O)(=O)C4=CC(=C(C=C4)NC(CCN5CCOCC5)CSC6=CC=CC=C6)S(=O)(=O)C(F)(F)F)C7=CC=C(C=C7)Cl)C
Inchikey:	JLYAXFNOILIKPP-KXQOOQHDSA-N
Pubchem:	24978538

Database

Identifier

Smiles:

CC1(CCC(=C(C1)CN2CCN(CC2)C3=CC=C(C=C3)C(=O)NS(=O)(=O)C4=CC(=C(C=C4)NC(CCN5CCOCC5)CSC6=CC=CC=C6)S(=O)(=O)C(F)(F)F)C7=CC=C(C=C7)Cl)C

Inchikey:

JLYAXFNOILIKPP-KXQOOQHDSA-N

Pubchem:

Top molecular features associated with response to ABT-263

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	ZNF660	CTRPv2	pan-cancer	AAC	0.23	4e-08
mRNA	SLC26A5	CTRPv2	pan-cancer	AAC	0.19	4e-08
mRNA	GIGYF1	CTRPv2	pan-cancer	AAC	0.21	4e-08
mRNA	FBRSL1	CTRPv2	pan-cancer	AAC	0.2	4e-08
mRNA	USP11	CTRPv2	pan-cancer	AAC	0.2	4e-08
mRNA	ZNF416	CTRPv2	pan-cancer	AAC	0.19	4e-08
mRNA	TMEM179	CTRPv2	pan-cancer	AAC	0.2	5e-08
mRNA	MAST1	CTRPv2	pan-cancer	AAC	0.21	5e-08
mRNA	ATP2B3	CTRPv2	pan-cancer	AAC	0.2	5e-08
mRNA	CTD-2583A14.9	CTRPv2	pan-cancer	AAC	0.2	5e-08