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ABT-263

Synonyms

SourcesNames Used
GDSC1000, FIMMNavitoclax
CTRPv2navitoclax
PharmacoGx ABT-263

External IDs

DatabaseIdentifier
Smiles: CC1(CCC(=C(C1)CN2CCN(CC2)C3=CC=C(C=C3)C(=O)NS(=O)(=O)C4=CC(=C(C=C4)NC(CCN5CCOCC5)CSC6=CC=CC=C6)S(=O)(=O)C(F)(F)F)C7=CC=C(C=C7)Cl)C
Inchikey: JLYAXFNOILIKPP-KXQOOQHDSA-N
Pubchem: 24978538

Annotated Targets

BCL2, BCL2L2, BAD

FDA Approval Status

Not Approved
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Top molecular features associated with response to ABT-263


Feature TypeStandardized
Nominal ANOVA
mRNA C14orf132 CTRPv2 pan-cancer AAC 0.24 5e-09
mRNA ZNF443 CTRPv2 pan-cancer AAC 0.22 5e-09
mRNA DOK6 CTRPv2 pan-cancer AAC 0.21 5e-09
mRNA UCP3 CTRPv2 pan-cancer AAC 0.21 5e-09
mRNA PAXBP1 CTRPv2 pan-cancer AAC 0.22 6e-09
mRNA GPR137C CTRPv2 pan-cancer AAC 0.22 6e-09
mRNA ZNF776 CTRPv2 pan-cancer AAC 0.21 6e-09
mRNA CAMK2B CTRPv2 pan-cancer AAC 0.21 6e-09
mRNA PSD CTRPv2 pan-cancer AAC 0.22 6e-09
mRNA THEM4 CTRPv2 pan-cancer AAC -0.23 6e-09
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