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BIX02189

BIX02189

Synonyms

Sources	Names Used
GDSC1000	BIX02189
PharmacoGx	BIX02189

External IDs

Database	Identifier
Smiles:	CN(C)Cc1cccc(NC(c2ccccc2)=C2/C(=O)Nc3cc(ccc23)C(=O)N(C)C)c1
Pubchem:	46931012

Annotated Targets

MAP2K5, MAPK7

FDA Approval Status

Not Approved

Dataset Select

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Top molecular features associated with response to BIX02189

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	RASGRP2	GDSC1000	pan-cancer	AAC	0.26	2e-09
mRNA	MLC1	GDSC1000	pan-cancer	AAC	0.26	1e-14
mRNA	MYB	GDSC1000	pan-cancer	AAC	0.27	6e-09
mRNA	AIF1	GDSC1000	pan-cancer	AAC	0.27	2e-13
mRNA	P2RY8	GDSC1000	pan-cancer	AAC	0.27	6e-06
mRNA	LST1	GDSC1000	pan-cancer	AAC	0.27	3e-13
mRNA	PRSS57	GDSC1000	pan-cancer	AAC	0.28	1e-16
mRNA	GMFG	GDSC1000	pan-cancer	AAC	0.29	6e-07
mRNA	LAIR1	GDSC1000	pan-cancer	AAC	0.3	2e-13
mRNA	PTPN7	GDSC1000	pan-cancer	AAC	0.3	3e-09

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