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BIX02189

BIX02189

Synonyms

Sources	Names Used
GDSC1000	BIX02189
PharmacoGx	BIX02189

External IDs

Database	Identifier
Smiles:	CN(C)Cc1cccc(NC(c2ccccc2)=C2/C(=O)Nc3cc(ccc23)C(=O)N(C)C)c1
Pubchem:	46931012

Annotated Targets

MAP2K5, MAPK7

FDA Approval Status

Not Approved

Dataset Select

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Top molecular features associated with response to BIX02189

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	CTSG	GDSC1000	pan-cancer	AAC	0.16	1e-06
mRNA	RUNX1	GDSC1000	pan-cancer	AAC	0.16	1e-06
mRNA	ZNF439	GDSC1000	pan-cancer	AAC	0.15	2e-06
mRNA	ZNF763	GDSC1000	pan-cancer	AAC	0.15	2e-06
mRNA	FAM78A	GDSC1000	pan-cancer	AAC	0.2	2e-06
mRNA	RAB37	GDSC1000	pan-cancer	AAC	0.17	3e-06
mRNA	NAMPT	GDSC1000	pan-cancer	AAC	-0.15	3e-06
mRNA	AGO4	GDSC1000	pan-cancer	AAC	0.15	3e-06
mRNA	ZNF627	GDSC1000	pan-cancer	AAC	0.15	3e-06
mRNA	CD34	GDSC1000	pan-cancer	AAC	0.14	3e-06

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