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BIX02189

BIX02189

Synonyms

Sources	Names Used
GDSC1000	BIX02189
PharmacoGx	BIX02189

External IDs

Database	Identifier
Smiles:	CN(C)Cc1cccc(NC(c2ccccc2)=C2/C(=O)Nc3cc(ccc23)C(=O)N(C)C)c1
Pubchem:	46931012

Annotated Targets

MAP2K5, MAPK7

FDA Approval Status

Not Approved

Dataset Select

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Top molecular features associated with response to BIX02189

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	LYL1	GDSC1000	pan-cancer	AAC	0.22	3e-07
mRNA	IL21R	GDSC1000	pan-cancer	AAC	-0.2	3e-07
mRNA	PAN3	GDSC1000	pan-cancer	AAC	0.18	3e-07
mRNA	SPNS3	GDSC1000	pan-cancer	AAC	0.17	3e-07
mRNA	PECAM1	GDSC1000	pan-cancer	AAC	0.17	3e-07
mRNA	BAHCC1	GDSC1000	pan-cancer	AAC	0.16	4e-07
mRNA	DOCK8	GDSC1000	pan-cancer	AAC	0.23	5e-07
mRNA	APOBR	GDSC1000	pan-cancer	AAC	0.17	5e-07
mRNA	GMFG	GDSC1000	pan-cancer	AAC	0.29	6e-07
mRNA	WT1	GDSC1000	pan-cancer	AAC	0.16	6e-07

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