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BIX02189

BIX02189

Synonyms

Sources	Names Used
GDSC1000	BIX02189
PharmacoGx	BIX02189

External IDs

Database	Identifier
Smiles:	CN(C)Cc1cccc(NC(c2ccccc2)=C2/C(=O)Nc3cc(ccc23)C(=O)N(C)C)c1
Pubchem:	46931012

Annotated Targets

MAP2K5, MAPK7

FDA Approval Status

Not Approved

Dataset Select

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Top molecular features associated with response to BIX02189

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	ZNF84	GDSC1000	pan-cancer	AAC	0.16	7e-07
mRNA	ARHGEF6	GDSC1000	pan-cancer	AAC	0.2	7e-07
mRNA	BCL2A1	GDSC1000	pan-cancer	AAC	-0.18	8e-07
mRNA	ZNF136	GDSC1000	pan-cancer	AAC	0.16	9e-07
mRNA	CYSTM1	GDSC1000	pan-cancer	AAC	-0.16	1e-06
mRNA	CCL23	GDSC1000	pan-cancer	AAC	0.15	1e-06
mRNA	ZNF69	GDSC1000	pan-cancer	AAC	0.16	1e-06
mRNA	TNFRSF8	GDSC1000	pan-cancer	AAC	-0.16	1e-06
mRNA	TYROBP	GDSC1000	pan-cancer	AAC	0.16	1e-06
mRNA	RNASE2	GDSC1000	pan-cancer	AAC	0.15	1e-06

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