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AT-7519

AT-7519

Synonyms

Sources	Names Used
GDSC1000	AT-7519
PharmacoGx	AT-7519

External IDs

Database	Identifier
Smiles:	Clc1cccc(Cl)c1C(=O)Nc1c[nH]nc1C(=O)NC1CCNCC1
Pubchem:	11338033

Annotated Targets

CDK14, CDK1, CDK2, CDK4, CDK5, CDK6, CDK9

FDA Approval Status

Not Approved

Dataset Select

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Top molecular features associated with response to AT-7519

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	SEMA5A	GDSC1000	pan-cancer	AAC	-0.095	0.003
mRNA	FBXW2	GDSC1000	pan-cancer	AAC	0.087	0.004
mRNA	BTG1	GDSC1000	pan-cancer	AAC	0.086	0.004
mRNA	SRSF6	GDSC1000	pan-cancer	AAC	0.086	0.004
mRNA	CCDC130	GDSC1000	pan-cancer	AAC	0.092	0.004
mRNA	GORASP1	GDSC1000	pan-cancer	AAC	-0.089	0.004
mRNA	IL1RAPL1	GDSC1000	pan-cancer	AAC	-0.093	0.004
mRNA	LMF2	GDSC1000	pan-cancer	AAC	-0.092	0.004
mRNA	NKAIN2	GDSC1000	pan-cancer	AAC	0.086	0.004
mRNA	NR1D1	GDSC1000	pan-cancer	AAC	-0.085	0.004

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