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AT-7519

AT-7519

Synonyms

Sources	Names Used
GDSC1000	AT-7519
PharmacoGx	AT-7519

External IDs

Database	Identifier
Smiles:	Clc1cccc(Cl)c1C(=O)Nc1c[nH]nc1C(=O)NC1CCNCC1
Pubchem:	11338033

Annotated Targets

CDK14, CDK1, CDK2, CDK4, CDK5, CDK6, CDK9

FDA Approval Status

Not Approved

Dataset Select

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Top molecular features associated with response to AT-7519

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	LDOC1	GDSC1000	pan-cancer	AAC	-0.11	0.002
mRNA	NFKB1	GDSC1000	pan-cancer	AAC	-0.097	0.002
mRNA	KLHL25	GDSC1000	pan-cancer	AAC	0.092	0.002
mRNA	FAM83B	GDSC1000	pan-cancer	AAC	0.11	0.002
mRNA	SMIM4	GDSC1000	pan-cancer	AAC	-0.091	0.002
mRNA	SIRT1	GDSC1000	pan-cancer	AAC	0.095	0.002
mRNA	RAPGEF5	GDSC1000	pan-cancer	AAC	0.093	0.002
mRNA	HACD1	GDSC1000	pan-cancer	AAC	-0.089	0.002
mRNA	KHDRBS1	GDSC1000	pan-cancer	AAC	0.098	0.002
mRNA	MDGA2	GDSC1000	pan-cancer	AAC	-0.094	0.002

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