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XAV-939

XAV-939

Synonyms

Sources	Names Used
GDSC1000	XAV939
PharmacoGx	XAV-939

External IDs

Database	Identifier
Smiles:	C1CSCC2=C1NC(=NC2=O)C3=CC=C(C=C3)C(F)(F)F
Inchikey:	KLGQSVMIPOVQAX-UHFFFAOYSA-N
Pubchem:	2726824

Annotated Targets

TNKS, TNKS2

FDA Approval Status

Not Approved

Dataset Select

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Top molecular features associated with response to XAV-939

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	NTRK3	GDSC1000	pan-cancer	AAC	0.099	0.004
mRNA	HEATR5A	GDSC1000	pan-cancer	AAC	0.11	0.004
mRNA	TNNI1	GDSC1000	pan-cancer	AAC	0.097	0.004
mRNA	UGP2	GDSC1000	pan-cancer	AAC	0.1	0.004
mRNA	ARHGAP5	GDSC1000	pan-cancer	AAC	0.12	0.004
mRNA	IL1A	GDSC1000	pan-cancer	AAC	0.11	0.004
mRNA	LPIN1	GDSC1000	pan-cancer	AAC	-0.1	0.004
mRNA	EVA1C	GDSC1000	pan-cancer	AAC	0.11	0.004
mRNA	KLHL5	GDSC1000	pan-cancer	AAC	0.1	0.004
mRNA	SPRR2F	GDSC1000	pan-cancer	AAC	0.096	0.004

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