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XAV-939

XAV-939

Synonyms

Sources	Names Used
GDSC1000	XAV939
PharmacoGx	XAV-939

External IDs

Database	Identifier
Smiles:	C1CSCC2=C1NC(=NC2=O)C3=CC=C(C=C3)C(F)(F)F
Inchikey:	KLGQSVMIPOVQAX-UHFFFAOYSA-N
Pubchem:	2726824

Annotated Targets

TNKS, TNKS2

FDA Approval Status

Not Approved

Dataset Select

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Top molecular features associated with response to XAV-939

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	P4HA3	GDSC1000	pan-cancer	AAC	0.13	0.0001
mRNA	CHPT1	GDSC1000	pan-cancer	AAC	-0.13	0.0001
mRNA	LARGE1	GDSC1000	pan-cancer	AAC	-0.14	0.0001
mRNA	TTC38	GDSC1000	pan-cancer	AAC	-0.13	0.0002
mRNA	MFAP5	GDSC1000	pan-cancer	AAC	0.13	0.0002
mRNA	ANKRD24	GDSC1000	pan-cancer	AAC	-0.13	0.0002
mRNA	DIRAS3	GDSC1000	pan-cancer	AAC	0.13	0.0002
mRNA	MALSU1	GDSC1000	pan-cancer	AAC	0.13	0.0002
mRNA	FAM126A	GDSC1000	pan-cancer	AAC	0.15	0.0003
mRNA	C8orf4	GDSC1000	pan-cancer	AAC	0.13	0.0003

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