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XAV-939

XAV-939

Synonyms

Sources	Names Used
GDSC1000	XAV939
PharmacoGx	XAV-939

External IDs

Database	Identifier
Smiles:	C1CSCC2=C1NC(=NC2=O)C3=CC=C(C=C3)C(F)(F)F
Inchikey:	KLGQSVMIPOVQAX-UHFFFAOYSA-N
Pubchem:	2726824

Annotated Targets

TNKS, TNKS2

FDA Approval Status

Not Approved

Dataset Select

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Top molecular features associated with response to XAV-939

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	VPS26B	GDSC1000	pan-cancer	AAC	-0.06	0.07
mRNA	DNMBP	GDSC1000	pan-cancer	AAC	0.066	0.07
mRNA	FYN	GDSC1000	pan-cancer	AAC	-0.069	0.07
mRNA	NEXN	GDSC1000	pan-cancer	AAC	0.069	0.07
mRNA	GPRC5C	GDSC1000	pan-cancer	AAC	0.069	0.07
mRNA	COMT	GDSC1000	pan-cancer	AAC	0.062	0.07
mRNA	ANGPTL4	GDSC1000	pan-cancer	AAC	0.061	0.07
mRNA	PIP5K1B	GDSC1000	pan-cancer	AAC	-0.07	0.07
mRNA	ADGRL3	GDSC1000	pan-cancer	AAC	0.062	0.07
mRNA	OR7G2	GDSC1000	pan-cancer	AAC	0.06	0.07

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