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XAV-939

XAV-939

Synonyms

Sources	Names Used
GDSC1000	XAV939
PharmacoGx	XAV-939

External IDs

Database	Identifier
Smiles:	C1CSCC2=C1NC(=NC2=O)C3=CC=C(C=C3)C(F)(F)F
Inchikey:	KLGQSVMIPOVQAX-UHFFFAOYSA-N
Pubchem:	2726824

Annotated Targets

TNKS, TNKS2

FDA Approval Status

Not Approved

Dataset Select

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Top molecular features associated with response to XAV-939

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	PRSS23	GDSC1000	pan-cancer	AAC	0.12	0.009
mRNA	PMEPA1	GDSC1000	pan-cancer	AAC	0.1	0.009
mRNA	SNRK	GDSC1000	pan-cancer	AAC	-0.1	0.009
mRNA	ERBIN	GDSC1000	pan-cancer	AAC	0.091	0.009
mRNA	CXCL6	GDSC1000	pan-cancer	AAC	0.09	0.009
mRNA	C19orf54	GDSC1000	pan-cancer	AAC	-0.094	0.009
mRNA	USP25	GDSC1000	pan-cancer	AAC	0.091	0.009
mRNA	G2E3	GDSC1000	pan-cancer	AAC	0.091	0.009
mRNA	PICALM	GDSC1000	pan-cancer	AAC	0.091	0.009
mRNA	SIGLEC10	GDSC1000	pan-cancer	AAC	0.098	0.009

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