About
Documentation
Cite Us!
Github
Download
News
Explore
Batch Query
Search
Site
Home
About
Documentation
PharmacoGx
Cite Us!
Tools
Explore
Batch Query
Search
GitHub
Datatypes
datasets
cell lines
tissues
drugs
genes
experiments
Home
/
Compounds
/
XAV-939
XAV-939
Synonyms
Sources
Names Used
GDSC1000
XAV939
PharmacoGx
XAV-939
External IDs
Database
Identifier
Smiles:
C1CSCC2=C1NC(=NC2=O)C3=CC=C(C=C3)C(F)(F)F
Inchikey:
KLGQSVMIPOVQAX-UHFFFAOYSA-N
Pubchem:
2726824
Annotated Targets
TNKS
,
TNKS2
FDA Approval Status
Not Approved
Plots
Cell Line Summary
Tissue Summary
Molecular Features
Number of cell lines tested with XAV-939
(per dataset)
0
100
200
300
400
500
600
700
800
900
# cell lines
CCLE
gCSI
GRAY
FIMM
CTRPv2
UHNBreast
GDSC1000
0
0
0
0
0
0
959
Download SVG
Number of tissues tested with XAV-939
(per dataset)
0
5
10
15
20
25
30
# tissues
CCLE
gCSI
GRAY
FIMM
CTRPv2
UHNBreast
GDSC1000
0
0
0
0
0
0
34
Download SVG
Dataset Select
all
GDSC1000
XAV-939: AAC
AAC
0.00
0.05
0.10
0.15
0.20
0.25
0.30
0.35
0.40
0.45
0.50
0.55
0.60
OV7
OV7
SU-DHL-5
SU-DHL-5
DB
DB
HT
HT
RCC-FG2
RCC-FG2
GB-1
GB-1
LXF-289
LXF-289
SAT
SAT
NCI-H292
NCI-H292
RPMI-8866
RPMI-8866
NCI-H2122
NCI-H2122
NCI-H2286
NCI-H2286
DU-145
DU-145
Geo
Geo
AsPC-1
AsPC-1
KNS-62
KNS-62
NCI-H446
NCI-H446
BFTC-909
BFTC-909
CAL-27
CAL-27
Calu-6
Calu-6
NCI-H647
NCI-H647
IMR-5
IMR-5
SF295
SF295
IOSE-397
IOSE-397
TC-YIK
TC-YIK
GT3TKB
GT3TKB
IST-SL1
IST-SL1
BHT-101
BHT-101
REH
REH
MDA-MB-436
MDA-MB-436
SHP-77
SHP-77
WM1552C
WM1552C
OCI-AML3
OCI-AML3
NB1
NB1
COR-L95
COR-L95
SIMA
SIMA
K1
K1
639-V
639-V
VMRC-MELG
VMRC-MELG
DIFI
DIFI
HUTU-80
HUTU-80
8505C
8505C
DSH1
DSH1
L-428
L-428
KYSE-50
KYSE-50
LCLC-103H
LCLC-103H
8305C
8305C
G-MEL
G-MEL
NY
NY
JHU-019
JHU-019
LN-18
LN-18
CAL-78
CAL-78
KM12
KM12
EN
EN
GP5d
GP5d
Set-2
Set-2
ES3
ES3
DBTRG-05MG
DBTRG-05MG
PCI-15A
PCI-15A
PFSK-1
PFSK-1
OV7
SU-DHL-5
DB
HT
RCC-FG2
GB-1
LXF-289
SAT
NCI-H292
RPMI-8866
NCI-H2122
NCI-H2286
DU-145
Geo
AsPC-1
KNS-62
NCI-H446
BFTC-909
CAL-27
Calu-6
NCI-H647
IMR-5
SF295
IOSE-397
TC-YIK
GT3TKB
IST-SL1
BHT-101
REH
MDA-MB-436
SHP-77
WM1552C
OCI-AML3
NB1
COR-L95
SIMA
K1
639-V
VMRC-MELG
DIFI
HUTU-80
8505C
DSH1
L-428
KYSE-50
LCLC-103H
8305C
G-MEL
NY
JHU-019
LN-18
CAL-78
KM12
EN
GP5d
Set-2
ES3
DBTRG-05MG
PCI-15A
PFSK-1
OV7: 0.64
Synonyms: OV7, OV-7
SU-DHL-5: 0.44
Synonyms: SU-DHL-5
DB: 0.35
Synonyms: DB
HT: 0.31
Synonyms: HT
RCC-FG2: 0.28
Synonyms: RCC-FG2
GB-1: 0.27
Synonyms: GB-1, GB1
LXF-289: 0.26
Synonyms: LXF-289, LXF289
SAT: 0.25
Synonyms: SAT
NCI-H292: 0.24
Synonyms: NCI-H292, H292
RPMI-8866: 0.24
Synonyms: RPMI-8866
NCI-H2122: 0.23
Synonyms: NCI-H2122, NCIH2122
NCI-H2286: 0.23
Synonyms: NCI-H2286, NCIH2286
DU-145: 0.23
Synonyms: DU-145, DU 145, DU_145, DU145
Geo: 0.22
Synonyms: Geo
AsPC-1: 0.22
Synonyms: AsPC-1, ASPC1
KNS-62: 0.21
Synonyms: KNS-62, KNS62
NCI-H446: 0.21
Synonyms: NCI-H446, NCIH446
BFTC-909: 0.21
Synonyms: BFTC-909, BFTC909
CAL-27: 0.20
Synonyms: CAL-27, CAL 27, CAL_27, CAL27
Calu-6: 0.20
Synonyms: Calu-6, CALU6
NCI-H647: 0.20
Synonyms: NCI-H647, NCIH647
IMR-5: 0.19
Synonyms: IMR-5
SF295: 0.19
Synonyms: SF295, SF-295
IOSE-397: 0.18
Synonyms: IOSE-397
TC-YIK: 0.18
Synonyms: TC-YIK
GT3TKB: 0.18
Synonyms: GT3TKB
IST-SL1: 0.18
Synonyms: IST-SL1
BHT-101: 0.18
Synonyms: BHT-101, BHT101
REH: 0.17
Synonyms: REH, Reh
MDA-MB-436: 0.17
Synonyms: MDA-MB-436, MDAMB436, mdamb436
: 0.00
Synonyms:
: 0.00
Synonyms:
: 0.00
Synonyms:
: 0.00
Synonyms:
: 0.00
Synonyms:
SHP-77: 0.00
Synonyms: SHP-77, SHP77
WM1552C: 0.00
Synonyms: WM1552C
OCI-AML3: 0.00
Synonyms: OCI-AML3, OCIAML3
NB1: 0.00
Synonyms: NB1, NB-1
COR-L95: 0.00
Synonyms: COR-L95, CORL95
SIMA: 0.00
Synonyms: SIMA
K1: 0.00
Synonyms: K1
639-V: 0.00
Synonyms: 639-V, 639V
VMRC-MELG: 0.00
Synonyms: VMRC-MELG
DIFI: 0.00
Synonyms: DIFI
HUTU-80: 0.00
Synonyms: HUTU-80, HuTu 80, HuTu_80
8505C: 0.00
Synonyms: 8505C
DSH1: 0.00
Synonyms: DSH1
L-428: 0.00
Synonyms: L-428, L428
KYSE-50: 0.00
Synonyms: KYSE-50
LCLC-103H: 0.00
Synonyms: LCLC-103H, LCLC103H
8305C: 0.00
Synonyms: 8305C
G-MEL: 0.00
Synonyms: G-MEL
NY: 0.00
Synonyms: NY
JHU-019: 0.00
Synonyms: JHU-019
LN-18: 0.00
Synonyms: LN-18, LN18
CAL-78: 0.00
Synonyms: CAL-78, CAL78
KM12: 0.00
Synonyms: KM12, KM-12
EN: 0.00
Synonyms: EN
GP5d: 0.00
Synonyms: GP5d
Set-2: 0.00
Synonyms: Set-2, Set2, SET-2, SET2
ES3: 0.00
Synonyms: ES3
DBTRG-05MG: 0.00
Synonyms: DBTRG-05MG, DBTRG05MG
PCI-15A: 0.00
Synonyms: PCI-15A
PFSK-1: 0.00
Synonyms: PFSK-1
Download SVG
0.00
5.00
10.00
15.00
20.00
25.00
MHH-PREB-1
MHH-PREB-1
MDA-MB-415
MDA-MB-415
MONO-MAC-6
MONO-MAC-6
MC-CAR
MC-CAR
RVH-421
RVH-421
NCI-H2286
NCI-H2286
HuO-3N1
HuO-3N1
KYM-1
KYM-1
DEL
DEL
DB
DB
ARH-77
ARH-77
MEL-HO
MEL-HO
SUP-M2
SUP-M2
LU-135
LU-135
Raji
Raji
BE-13
BE-13
COR-L23
COR-L23
IMR-5
IMR-5
CTB-1
CTB-1
SK-GT-4
SK-GT-4
BT-549
BT-549
NB10
NB10
DND-41
DND-41
P12-ICHIKAWA
P12-ICHIKAWA
NCI-H2291
NCI-H2291
A101D
A101D
KOSC-2
KOSC-2
HGC-27
HGC-27
HCC1569
HCC1569
Mo-T
Mo-T
MDA-MB-231
MDA-MB-231
Hep 3B2.1-7
Hep 3B2.1-7
EW-16
EW-16
ES6
ES6
CAL-54
CAL-54
TCCSUP
TCCSUP
IOSE-75-16SV40
IOSE-75-16SV40
OUMS-23
OUMS-23
NCI-H2405
NCI-H2405
MSTO-211H
MSTO-211H
Farage
Farage
SAT
SAT
CaR-1
CaR-1
EMC-BAC-2
EMC-BAC-2
OAW-42
OAW-42
OVCA433
OVCA433
NB7
NB7
NCI-H2122
NCI-H2122
ETK-1
ETK-1
JHOS-2
JHOS-2
NCI-H647
NCI-H647
HCC1187
HCC1187
WSU-DLCL2
WSU-DLCL2
NCI-H3122
NCI-H3122
IOSE-397
IOSE-397
ABC-1
ABC-1
GT3TKB
GT3TKB
BHT-101
BHT-101
Geo
Geo
NCI-H292
NCI-H292
MHH-PREB-1
MDA-MB-415
MONO-MAC-6
MC-CAR
RVH-421
NCI-H2286
HuO-3N1
KYM-1
DEL
DB
ARH-77
MEL-HO
SUP-M2
LU-135
Raji
BE-13
COR-L23
IMR-5
CTB-1
SK-GT-4
BT-549
NB10
DND-41
P12-ICHIKAWA
NCI-H2291
A101D
KOSC-2
HGC-27
HCC1569
Mo-T
MDA-MB-231
Hep 3B2.1-7
EW-16
ES6
CAL-54
TCCSUP
IOSE-75-16SV40
OUMS-23
NCI-H2405
MSTO-211H
Farage
SAT
CaR-1
EMC-BAC-2
OAW-42
OVCA433
NB7
NCI-H2122
ETK-1
JHOS-2
NCI-H647
HCC1187
WSU-DLCL2
NCI-H3122
IOSE-397
ABC-1
GT3TKB
BHT-101
Geo
NCI-H292
MHH-PREB-1: 28.90 (log10 µM)
Synonyms: MHH-PREB-1
MDA-MB-415: 18.06 (log10 µM)
Synonyms: MDA-MB-415, MDAMB415, mdamb415
MONO-MAC-6: 16.88 (log10 µM)
Synonyms: MONO-MAC-6, MONOMAC6
MC-CAR: 15.72 (log10 µM)
Synonyms: MC-CAR
RVH-421: 14.55 (log10 µM)
Synonyms: RVH-421, RVH421
NCI-H2286: 14.15 (log10 µM)
Synonyms: NCI-H2286, NCIH2286
HuO-3N1: 13.89 (log10 µM)
Synonyms: HuO-3N1
KYM-1: 13.23 (log10 µM)
Synonyms: KYM-1, KYM1
DEL: 13.00 (log10 µM)
Synonyms: DEL
DB: 11.68 (log10 µM)
Synonyms: DB
ARH-77: 10.59 (log10 µM)
Synonyms: ARH-77
MEL-HO: 9.77 (log10 µM)
Synonyms: MEL-HO, MELHO
SUP-M2: 9.57 (log10 µM)
Synonyms: SUP-M2, SUPM2
LU-135: 8.79 (log10 µM)
Synonyms: LU-135
Raji: 8.77 (log10 µM)
Synonyms: Raji, RAJI
BE-13: 8.33 (log10 µM)
Synonyms: BE-13
COR-L23: 8.19 (log10 µM)
Synonyms: COR-L23
IMR-5: 8.17 (log10 µM)
Synonyms: IMR-5
CTB-1: 8.16 (log10 µM)
Synonyms: CTB-1
SK-GT-4: 7.82 (log10 µM)
Synonyms: SK-GT-4
BT-549: 7.55 (log10 µM)
Synonyms: BT-549, BT549, bt549
NB10: 7.42 (log10 µM)
Synonyms: NB10
DND-41: 6.48 (log10 µM)
Synonyms: DND-41, DND41
P12-ICHIKAWA: 6.28 (log10 µM)
Synonyms: P12-ICHIKAWA, P12ICHIKAWA
NCI-H2291: 6.22 (log10 µM)
Synonyms: NCI-H2291, NCIH2291
A101D: 6.17 (log10 µM)
Synonyms: A101D
KOSC-2: 6.15 (log10 µM)
Synonyms: KOSC-2
HGC-27: 6.06 (log10 µM)
Synonyms: HGC-27, HGC27
HCC1569: 6.03 (log10 µM)
Synonyms: HCC1569, hcc1569
Mo-T: 6.00 (log10 µM)
Synonyms: Mo-T
: 0.00 (log10 µM)
Synonyms:
: 0.00 (log10 µM)
Synonyms:
: 0.00 (log10 µM)
Synonyms:
: 0.00 (log10 µM)
Synonyms:
: 0.00 (log10 µM)
Synonyms:
MDA-MB-231: 0.85 (log10 µM)
Synonyms: MDA-MB-231, MDAMB231, mdamb231
Hep 3B2.1-7: 0.85 (log10 µM)
Synonyms: Hep 3B2.1-7, Hep_3B2.1-7, Hep3B2-1-7, Hep 3B2_1-7, Hep_3B2_1-7, HEP3B217
EW-16: 0.84 (log10 µM)
Synonyms: EW-16
ES6: 0.83 (log10 µM)
Synonyms: ES6
CAL-54: 0.83 (log10 µM)
Synonyms: CAL-54, CAL 54, CAL54
TCCSUP: 0.83 (log10 µM)
Synonyms: TCCSUP
IOSE-75-16SV40: 0.83 (log10 µM)
Synonyms: IOSE-75-16SV40
OUMS-23: 0.82 (log10 µM)
Synonyms: OUMS-23, OUMS23
NCI-H2405: 0.79 (log10 µM)
Synonyms: NCI-H2405, NCIH2405
MSTO-211H: 0.75 (log10 µM)
Synonyms: MSTO-211H, MSTO211H
Farage: 0.73 (log10 µM)
Synonyms: Farage
SAT: 0.73 (log10 µM)
Synonyms: SAT
CaR-1: 0.65 (log10 µM)
Synonyms: CaR-1
EMC-BAC-2: 0.62 (log10 µM)
Synonyms: EMC-BAC-2
OAW-42: 0.43 (log10 µM)
Synonyms: OAW-42, OAW42
OVCA433: 0.35 (log10 µM)
Synonyms: OVCA433
NB7: 0.33 (log10 µM)
Synonyms: NB7
NCI-H2122: 0.33 (log10 µM)
Synonyms: NCI-H2122, NCIH2122
ETK-1: 0.32 (log10 µM)
Synonyms: ETK-1
JHOS-2: 0.31 (log10 µM)
Synonyms: JHOS-2, JHOS2
NCI-H647: 0.30 (log10 µM)
Synonyms: NCI-H647, NCIH647
HCC1187: 0.26 (log10 µM)
Synonyms: HCC1187, hcc1187
WSU-DLCL2: 0.25 (log10 µM)
Synonyms: WSU-DLCL2, WSUDLCL2
NCI-H3122: 0.22 (log10 µM)
Synonyms: NCI-H3122
IOSE-397: 0.18 (log10 µM)
Synonyms: IOSE-397
ABC-1: 0.13 (log10 µM)
Synonyms: ABC-1
GT3TKB: 0.07 (log10 µM)
Synonyms: GT3TKB
BHT-101: -0.11 (log10 µM)
Synonyms: BHT-101, BHT101
Geo: -0.52 (log10 µM)
Synonyms: Geo
NCI-H292: -0.54 (log10 µM)
Synonyms: NCI-H292, H292
AAC
pIC50
* Plot represents the top and bottom 30 data points
** Error Bars represent the Median Absolute Deviation
Download SVG
Download Data as CSV
XAV-939: AAC
AAC
Tissues
0.00
0.05
0.10
0.15
0.20
0.25
0.30
0.35
0.40
0.45
0.50
0.55
0.60
small_intestine
small_intestine
neuroblastoma
neuroblastoma
large_intestine
large_intestine
autonomic_ganglia
autonomic_ganglia
other
other
skin
skin
adrenal_gland
adrenal_gland
endometrium
endometrium
thyroid
thyroid
urinary_tract
urinary_tract
breast
breast
oesophagus
oesophagus
bone
bone
prostate
prostate
soft_tissue
soft_tissue
central_nervous_system
central_nervous_system
liver
liver
oral_cavity
oral_cavity
pleura
pleura
placenta
placenta
haematopoietic_and_lymphoid_tissue
haematopoietic_and_lymphoid_tissue
lung
lung
biliary_tract
biliary_tract
pancreas
pancreas
upper_aerodigestive_tract
upper_aerodigestive_tract
stomach
stomach
kidney
kidney
ovary
ovary
cervix
cervix
salivary_gland
salivary_gland
head_and_neck
head_and_neck
vulva
vulva
testis
testis
misc
misc
-4.00
-2.00
0.00
2.00
4.00
6.00
8.00
10.00
12.00
14.00
16.00
testis
testis
misc
misc
oral_cavity
oral_cavity
neuroblastoma
neuroblastoma
placenta
placenta
small_intestine
small_intestine
adrenal_gland
adrenal_gland
biliary_tract
biliary_tract
liver
liver
thyroid
thyroid
large_intestine
large_intestine
urinary_tract
urinary_tract
pancreas
pancreas
head_and_neck
head_and_neck
vulva
vulva
ovary
ovary
soft_tissue
soft_tissue
breast
breast
central_nervous_system
central_nervous_system
kidney
kidney
skin
skin
endometrium
endometrium
salivary_gland
salivary_gland
pleura
pleura
oesophagus
oesophagus
lung
lung
bone
bone
autonomic_ganglia
autonomic_ganglia
upper_aerodigestive_tract
upper_aerodigestive_tract
prostate
prostate
cervix
cervix
stomach
stomach
other
other
haematopoietic_and_lymphoid_tissue
haematopoietic_and_lymphoid_tissue
AAC
pIC50
= Truncated outliers
Download SVG
Top molecular features associated with response to XAV-939
Feature Type
Gene
Dataset
Tissue
Stat
Standardized
Coefficient
Nominal ANOVA
p-value
mRNA
TRIM22
GDSC1000
pan-cancer
AAC
0.072
0.07
mRNA
COL7A1
GDSC1000
pan-cancer
AAC
0.075
0.07
mRNA
DCP1A
GDSC1000
pan-cancer
AAC
-0.069
0.07
mRNA
FAM83A
GDSC1000
pan-cancer
AAC
0.067
0.07
mRNA
SLC44A4
GDSC1000
pan-cancer
AAC
-0.067
0.07
mRNA
FGFR1OP2
GDSC1000
pan-cancer
AAC
0.062
0.07
mRNA
RAB36
GDSC1000
pan-cancer
AAC
-0.06
0.07
mRNA
RPS28
GDSC1000
pan-cancer
AAC
-0.064
0.07
mRNA
DYM
GDSC1000
pan-cancer
AAC
-0.065
0.07
mRNA
RAB18
GDSC1000
pan-cancer
AAC
0.065
0.07
← Previous
1
2
…
166
167
168
…
199
200
Next →
Download CSV