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XAV-939

XAV-939

Synonyms

Sources	Names Used
GDSC1000	XAV939
PharmacoGx	XAV-939

External IDs

Database	Identifier
Smiles:	C1CSCC2=C1NC(=NC2=O)C3=CC=C(C=C3)C(F)(F)F
Inchikey:	KLGQSVMIPOVQAX-UHFFFAOYSA-N
Pubchem:	2726824

Annotated Targets

TNKS, TNKS2

FDA Approval Status

Not Approved

Dataset Select

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Top molecular features associated with response to XAV-939

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	ZSWIM5	GDSC1000	pan-cancer	AAC	-0.067	0.07
mRNA	CECR2	GDSC1000	pan-cancer	AAC	-0.063	0.07
mRNA	TMEM167A	GDSC1000	pan-cancer	AAC	0.062	0.07
mRNA	DIS3L2	GDSC1000	pan-cancer	AAC	-0.063	0.07
mRNA	PPP1R21	GDSC1000	pan-cancer	AAC	-0.064	0.07
mRNA	SLC22A4	GDSC1000	pan-cancer	AAC	0.065	0.07
mRNA	RPA2	GDSC1000	pan-cancer	AAC	-0.07	0.07
mRNA	ENGASE	GDSC1000	pan-cancer	AAC	-0.064	0.07
mRNA	CAPN1	GDSC1000	pan-cancer	AAC	0.076	0.07
mRNA	PLD1	GDSC1000	pan-cancer	AAC	0.066	0.07

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