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XAV-939

XAV-939

Synonyms

Sources	Names Used
GDSC1000	XAV939
PharmacoGx	XAV-939

External IDs

Database	Identifier
Smiles:	C1CSCC2=C1NC(=NC2=O)C3=CC=C(C=C3)C(F)(F)F
Inchikey:	KLGQSVMIPOVQAX-UHFFFAOYSA-N
Pubchem:	2726824

Annotated Targets

TNKS, TNKS2

FDA Approval Status

Not Approved

Dataset Select

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Top molecular features associated with response to XAV-939

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	CH25H	GDSC1000	pan-cancer	AAC	0.067	0.07
mRNA	CRELD2	GDSC1000	pan-cancer	AAC	-0.065	0.07
mRNA	RIT2	GDSC1000	pan-cancer	AAC	-0.062	0.07
mRNA	GPRC5A	GDSC1000	pan-cancer	AAC	0.081	0.07
mRNA	ARFGEF2	GDSC1000	pan-cancer	AAC	-0.067	0.07
mRNA	CDC20B	GDSC1000	pan-cancer	AAC	0.062	0.07
mRNA	GKAP1	GDSC1000	pan-cancer	AAC	-0.068	0.07
mRNA	PREPL	GDSC1000	pan-cancer	AAC	-0.064	0.07
mRNA	TAPBP	GDSC1000	pan-cancer	AAC	0.068	0.07
mRNA	HNRNPCL1	GDSC1000	pan-cancer	AAC	0.062	0.07

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