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XAV-939

XAV-939

Synonyms

Sources	Names Used
GDSC1000	XAV939
PharmacoGx	XAV-939

External IDs

Database	Identifier
Smiles:	C1CSCC2=C1NC(=NC2=O)C3=CC=C(C=C3)C(F)(F)F
Inchikey:	KLGQSVMIPOVQAX-UHFFFAOYSA-N
Pubchem:	2726824

Annotated Targets

TNKS, TNKS2

FDA Approval Status

Not Approved

Dataset Select

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Top molecular features associated with response to XAV-939

Feature Type	Gene	Dataset	Tissue	Stat	Standardized Coefficient	Nominal ANOVA p-value
mRNA	DNASE1L1	GDSC1000	pan-cancer	AAC	-0.068	0.07
mRNA	OGDHL	GDSC1000	pan-cancer	AAC	-0.066	0.07
mRNA	METTL6	GDSC1000	pan-cancer	AAC	-0.065	0.07
mRNA	ALG10B	GDSC1000	pan-cancer	AAC	-0.067	0.07
mRNA	ATP5S	GDSC1000	pan-cancer	AAC	-0.067	0.07
mRNA	LBX2	GDSC1000	pan-cancer	AAC	-0.065	0.07
mRNA	AKAP11	GDSC1000	pan-cancer	AAC	0.064	0.07
mRNA	PPCDC	GDSC1000	pan-cancer	AAC	-0.069	0.07
mRNA	CUL4B	GDSC1000	pan-cancer	AAC	0.067	0.07
mRNA	ADGRG3	GDSC1000	pan-cancer	AAC	-0.064	0.07

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